Inflammation, nutritional status, pufa profile and outcome in hemodialysis patients
2012
Authors
Peruničić-Peković, GordanaRašić-Milutinović, Zorica
Gluvić, Zoran
Lačković, Milena
Ristić-Medić, Danijela
Glibetić, Marija
Article (Published version)
Metadata
Show full item recordAbstract
Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The basic mechanisms of these disorders are connected with changes in cell functions at the membrane level. Vascular smooth muscle cell proliferation plays an important role in the pathogenesis of atherosclerosis. We have examined the association between atherosclerotic risk factors and nutritional status in hemodialysis (HD) patients. Mortality was followed for up to 18 month. Forty-three HD patients were examined (20 males, 23 females, ages 55±12 years). Nutritional and inflammatory markers, including serum concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was signi...ficant positive correlation between the plasma albumin level and CRP. Significant correlation was found between plasma the cholesterol level and some PUFA. Increasing inflammation and endothelial dysfunction predict the development of vascular disease. We report on the relationship between inflammatory markers and nutritional parameter, indices of atherosclerosis and other cardiovascular risk factors in patients on hemodialysis.
Keywords:
malnutrition / inflammation / hemodialysis / PUFAsSource:
Archives of Biological Sciences, 2012, 64, 3, 1173-1180Publisher:
- Srpsko biološko društvo, Beograd, i dr.
Funding / projects:
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
DOI: 10.2298/ABS1203173P
ISSN: 0354-4664
WoS: 000308511300037
Scopus: 2-s2.0-84867850351
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Peruničić-Peković, Gordana AU - Rašić-Milutinović, Zorica AU - Gluvić, Zoran AU - Lačković, Milena AU - Ristić-Medić, Danijela AU - Glibetić, Marija PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/428 AB - Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The basic mechanisms of these disorders are connected with changes in cell functions at the membrane level. Vascular smooth muscle cell proliferation plays an important role in the pathogenesis of atherosclerosis. We have examined the association between atherosclerotic risk factors and nutritional status in hemodialysis (HD) patients. Mortality was followed for up to 18 month. Forty-three HD patients were examined (20 males, 23 females, ages 55±12 years). Nutritional and inflammatory markers, including serum concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was significant positive correlation between the plasma albumin level and CRP. Significant correlation was found between plasma the cholesterol level and some PUFA. Increasing inflammation and endothelial dysfunction predict the development of vascular disease. We report on the relationship between inflammatory markers and nutritional parameter, indices of atherosclerosis and other cardiovascular risk factors in patients on hemodialysis. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - Inflammation, nutritional status, pufa profile and outcome in hemodialysis patients EP - 1180 IS - 3 SP - 1173 VL - 64 DO - 10.2298/ABS1203173P ER -
@article{ author = "Peruničić-Peković, Gordana and Rašić-Milutinović, Zorica and Gluvić, Zoran and Lačković, Milena and Ristić-Medić, Danijela and Glibetić, Marija", year = "2012", abstract = "Patients with end-stage renal disease (ESRD) include a significant percentage of malnourished patients with other risk factors: dyslipoproteinemia, insulin resistance, increased oxidative stress and inflammation that together impair endothelial function. Abnormal polyunsaturated fatty acids (PUFA) patterns are reported in patients with ESRD. The basic mechanisms of these disorders are connected with changes in cell functions at the membrane level. Vascular smooth muscle cell proliferation plays an important role in the pathogenesis of atherosclerosis. We have examined the association between atherosclerotic risk factors and nutritional status in hemodialysis (HD) patients. Mortality was followed for up to 18 month. Forty-three HD patients were examined (20 males, 23 females, ages 55±12 years). Nutritional and inflammatory markers, including serum concentrations of C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha), and interleukin 6 (IL-6), were measured. There was significant positive correlation between the plasma albumin level and CRP. Significant correlation was found between plasma the cholesterol level and some PUFA. Increasing inflammation and endothelial dysfunction predict the development of vascular disease. We report on the relationship between inflammatory markers and nutritional parameter, indices of atherosclerosis and other cardiovascular risk factors in patients on hemodialysis.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "Inflammation, nutritional status, pufa profile and outcome in hemodialysis patients", pages = "1180-1173", number = "3", volume = "64", doi = "10.2298/ABS1203173P" }
Peruničić-Peković, G., Rašić-Milutinović, Z., Gluvić, Z., Lačković, M., Ristić-Medić, D.,& Glibetić, M.. (2012). Inflammation, nutritional status, pufa profile and outcome in hemodialysis patients. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 64(3), 1173-1180. https://doi.org/10.2298/ABS1203173P
Peruničić-Peković G, Rašić-Milutinović Z, Gluvić Z, Lačković M, Ristić-Medić D, Glibetić M. Inflammation, nutritional status, pufa profile and outcome in hemodialysis patients. in Archives of Biological Sciences. 2012;64(3):1173-1180. doi:10.2298/ABS1203173P .
Peruničić-Peković, Gordana, Rašić-Milutinović, Zorica, Gluvić, Zoran, Lačković, Milena, Ristić-Medić, Danijela, Glibetić, Marija, "Inflammation, nutritional status, pufa profile and outcome in hemodialysis patients" in Archives of Biological Sciences, 64, no. 3 (2012):1173-1180, https://doi.org/10.2298/ABS1203173P . .