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Transforming growth factor-β superfamily, implications in development and differentiation of stem cells
dc.creator | Santibanez, Juan F. | |
dc.creator | Kocić, Jelena | |
dc.date.accessioned | 2021-04-20T12:29:20Z | |
dc.date.available | 2021-04-20T12:29:20Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 1868-5021 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/417 | |
dc.description.abstract | Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotropic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation. | en |
dc.publisher | De Gruyter | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Biomolecular Concepts | |
dc.subject | BMP | en |
dc.subject | differentiation | en |
dc.subject | signaling | en |
dc.subject | stem cells | en |
dc.subject | TGF-β | en |
dc.title | Transforming growth factor-β superfamily, implications in development and differentiation of stem cells | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.epage | 445 | |
dc.citation.issue | 5 | |
dc.citation.other | 3(5): 429-445 | |
dc.citation.spage | 429 | |
dc.citation.volume | 3 | |
dc.identifier.doi | 10.1515/bmc-2012-0015 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/323/414.pdf | |
dc.identifier.scopus | 2-s2.0-84893825375 | |
dc.type.version | publishedVersion |