Transforming growth factor-β superfamily, implications in development and differentiation of stem cells
Апстракт
Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotrop...ic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation.
Кључне речи:
BMP / differentiation / signaling / stem cells / TGF-βИзвор:
Biomolecular Concepts, 2012, 3, 5, 429-445Издавач:
- De Gruyter
Финансирање / пројекти:
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Santibanez, Juan F. AU - Kocić, Jelena PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/417 AB - Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotropic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation. PB - De Gruyter T2 - Biomolecular Concepts T1 - Transforming growth factor-β superfamily, implications in development and differentiation of stem cells EP - 445 IS - 5 SP - 429 VL - 3 DO - 10.1515/bmc-2012-0015 ER -
@article{ author = "Santibanez, Juan F. and Kocić, Jelena", year = "2012", abstract = "Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotropic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation.", publisher = "De Gruyter", journal = "Biomolecular Concepts", title = "Transforming growth factor-β superfamily, implications in development and differentiation of stem cells", pages = "445-429", number = "5", volume = "3", doi = "10.1515/bmc-2012-0015" }
Santibanez, J. F.,& Kocić, J.. (2012). Transforming growth factor-β superfamily, implications in development and differentiation of stem cells. in Biomolecular Concepts De Gruyter., 3(5), 429-445. https://doi.org/10.1515/bmc-2012-0015
Santibanez JF, Kocić J. Transforming growth factor-β superfamily, implications in development and differentiation of stem cells. in Biomolecular Concepts. 2012;3(5):429-445. doi:10.1515/bmc-2012-0015 .
Santibanez, Juan F., Kocić, Jelena, "Transforming growth factor-β superfamily, implications in development and differentiation of stem cells" in Biomolecular Concepts, 3, no. 5 (2012):429-445, https://doi.org/10.1515/bmc-2012-0015 . .