Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotrop...ic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation.
TY - JOUR
AU - Santibanez, Juan
AU - Kocić, Jelena
PY - 2012
UR - http://rimi.imi.bg.ac.rs/handle/123456789/417
AB - Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotropic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation.
PB - De Gruyter
T2 - Biomolecular Concepts
T1 - Transforming growth factor-β superfamily, implications in development and differentiation of stem cells
EP - 445
IS - 5
SP - 429
VL - 3
DO - 10.1515/bmc-2012-0015
UR - conv_5113
ER -
@article{
author = "Santibanez, Juan and Kocić, Jelena",
year = "2012",
abstract = "Transforming growth factor-β (TGF-β) family members, including TGF-βs and bone morphogenetic proteins (BMPs), play important roles in directing the fate of stem cells. In embryonic stem cells, the TGF-β superfamily participates in almost all stages of cell development, such as cell maintenance, lineage selection, and progression of differentiation. In adult mesenchymal stem cells (MSCs), TGF-βs can provide competence for early stages of chondroblastic and osteoblastic differentiation, but they inhibit myogenesis, adipogenesis, and late-stage osteoblast differentiation. BMPs also inhibit adipogenesis and myogenesis, but they strongly promote osteoblast differentiation. The TGF-β superfamily members signal via specific serine/threonine kinase receptors and their nuclear effectors termed Smad proteins as well as through non-Smad pathways, which explain their pleiotropic effects in self-renewal and differentiation of stem cells. This review summarizes the current knowledge on the pleiotropic effects of the TGF-β superfamily of growth factors on the fate of stem cells and also discusses the mechanisms by which the TGF-β superfamily members control embryonic and MSCs differentiation.",
publisher = "De Gruyter",
journal = "Biomolecular Concepts",
title = "Transforming growth factor-β superfamily, implications in development and differentiation of stem cells",
pages = "445-429",
number = "5",
volume = "3",
doi = "10.1515/bmc-2012-0015",
url = "conv_5113"
}
Santibanez, J.,& Kocić, J.. (2012). Transforming growth factor-β superfamily, implications in development and differentiation of stem cells. in Biomolecular Concepts
De Gruyter., 3(5), 429-445.
https://doi.org/10.1515/bmc-2012-0015
conv_5113
Santibanez J, Kocić J. Transforming growth factor-β superfamily, implications in development and differentiation of stem cells. in Biomolecular Concepts. 2012;3(5):429-445.
doi:10.1515/bmc-2012-0015
conv_5113 .
Santibanez, Juan, Kocić, Jelena, "Transforming growth factor-β superfamily, implications in development and differentiation of stem cells" in Biomolecular Concepts, 3, no. 5 (2012):429-445,
https://doi.org/10.1515/bmc-2012-0015 .,
conv_5113 .
