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Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia

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2012
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Authors
Kovačević-Pavićević, Dragana
Radosavljević, A.
Ilić, Aleksandra
Kovačević, Igor
Đurković-Đaković, Olgica
Article (Published version)
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Abstract
Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma. Results In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one pati...ent each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047 +/- 0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (P lt 0.0001 and P = 0.006, respectively). Conclusion OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur. Eye (2012) 26, 723-728; doi: 10.1038/eye.2012.20; published online 24 February 2012

Keywords:
ocular toxoplasmosis / uveitis / clinical pattern / epidemiology / Serbia
Source:
Eye, 2012, 26, 5, 723-728
Publisher:
  • Nature Publishing Group, London
Funding / projects:
  • Control of infections by Apicomplexan pathogens: from novel drug targets to prediction (RS-41019)

DOI: 10.1038/eye.2012.20

ISSN: 0950-222X

PubMed: 22361847

WoS: 000303937400015

Scopus: 2-s2.0-84862548454
[ Google Scholar ]
14
12
URI
http://rimi.imi.bg.ac.rs/handle/123456789/412
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Kovačević-Pavićević, Dragana
AU  - Radosavljević, A.
AU  - Ilić, Aleksandra
AU  - Kovačević, Igor
AU  - Đurković-Đaković, Olgica
PY  - 2012
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/412
AB  - Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma. Results In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047 +/- 0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (P  lt  0.0001 and P = 0.006, respectively). Conclusion OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur. Eye (2012) 26, 723-728; doi: 10.1038/eye.2012.20; published online 24 February 2012
PB  - Nature Publishing Group, London
T2  - Eye
T1  - Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia
EP  - 728
IS  - 5
SP  - 723
VL  - 26
DO  - 10.1038/eye.2012.20
UR  - conv_2745
ER  - 
@article{
author = "Kovačević-Pavićević, Dragana and Radosavljević, A. and Ilić, Aleksandra and Kovačević, Igor and Đurković-Đaković, Olgica",
year = "2012",
abstract = "Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma. Results In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047 +/- 0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (P  lt  0.0001 and P = 0.006, respectively). Conclusion OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur. Eye (2012) 26, 723-728; doi: 10.1038/eye.2012.20; published online 24 February 2012",
publisher = "Nature Publishing Group, London",
journal = "Eye",
title = "Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia",
pages = "728-723",
number = "5",
volume = "26",
doi = "10.1038/eye.2012.20",
url = "conv_2745"
}
Kovačević-Pavićević, D., Radosavljević, A., Ilić, A., Kovačević, I.,& Đurković-Đaković, O.. (2012). Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia. in Eye
Nature Publishing Group, London., 26(5), 723-728.
https://doi.org/10.1038/eye.2012.20
conv_2745
Kovačević-Pavićević D, Radosavljević A, Ilić A, Kovačević I, Đurković-Đaković O. Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia. in Eye. 2012;26(5):723-728.
doi:10.1038/eye.2012.20
conv_2745 .
Kovačević-Pavićević, Dragana, Radosavljević, A., Ilić, Aleksandra, Kovačević, Igor, Đurković-Đaković, Olgica, "Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia" in Eye, 26, no. 5 (2012):723-728,
https://doi.org/10.1038/eye.2012.20 .,
conv_2745 .

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