Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia

2012
Authors
Kovačević-Pavićević, DraganaRadosavljević, A.
Ilić, Aleksandra

Kovačević, Igor
Đurković-Đaković, Olgica

Article (Published version)

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Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma. Results In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one pati...ent each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047 +/- 0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (P lt 0.0001 and P = 0.006, respectively). Conclusion OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur. Eye (2012) 26, 723-728; doi: 10.1038/eye.2012.20; published online 24 February 2012
Keywords:
ocular toxoplasmosis / uveitis / clinical pattern / epidemiology / SerbiaSource:
Eye, 2012, 26, 5, 723-728Publisher:
- Nature Publishing Group, London
Funding / projects:
DOI: 10.1038/eye.2012.20
ISSN: 0950-222X
PubMed: 22361847
WoS: 000303937400015
Scopus: 2-s2.0-84862548454
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Institut za medicinska istraživanjaTY - JOUR AU - Kovačević-Pavićević, Dragana AU - Radosavljević, A. AU - Ilić, Aleksandra AU - Kovačević, Igor AU - Đurković-Đaković, Olgica PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/412 AB - Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma. Results In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047 +/- 0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (P lt 0.0001 and P = 0.006, respectively). Conclusion OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur. Eye (2012) 26, 723-728; doi: 10.1038/eye.2012.20; published online 24 February 2012 PB - Nature Publishing Group, London T2 - Eye T1 - Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia EP - 728 IS - 5 SP - 723 VL - 26 DO - 10.1038/eye.2012.20 ER -
@article{ author = "Kovačević-Pavićević, Dragana and Radosavljević, A. and Ilić, Aleksandra and Kovačević, Igor and Đurković-Đaković, Olgica", year = "2012", abstract = "Purpose To analyze the clinical pattern of ocular toxoplasmosis (OT) in a referral centre in Serbia. Patients and methods The medical records of consecutive patients admitted for OT to the single referral centre for uveitis in Serbia between 2006 and 2010 were retrospectively analyzed. OT was diagnosed on the basis of typical fundus lesions and positive serology for Toxoplasma. Results In a total of 457 uveitis patients, OT was the third leading cause, with 59 patients (12.9%). Most OT cases (73%) were monocular. An active primary retinal lesion was observed in 36% and recurrent OT in 64% patients. Localization of lesions was central/paracentral (44%), juxtapapillar (27%), peripheral (19%), and multifocal (10%). Other ocular manifestations of inflammation included vitritis (44%), anterior uveitis (19%), and retinal vasculitis (10%). Complications included choroidal neovascularization in two and exudative retinal detachment with cataract, glaucoma, and cystoid macular oedema in one patient each. The detection of Toxoplasma-specific IgM antibodies in a single patient indicates a low rate of OT concomitant with acute infection. After treatment, the mean best-corrected visual acuity (BCVA) increased significantly. However, 14 (24%) patients ended up legally blind in the affected eye, of which 2 (3%) with bilateral blindness, all with a very poor BCVA (0.047 +/- 0.055) at presentation. Visual impairment and treatment outcome were both associated with central localization of lesions (P lt 0.0001 and P = 0.006, respectively). Conclusion OT is a significant cause of posterior uveitis in Serbia. Patients should be aware of the recurring nature of OT and react immediately if symptoms occur. Eye (2012) 26, 723-728; doi: 10.1038/eye.2012.20; published online 24 February 2012", publisher = "Nature Publishing Group, London", journal = "Eye", title = "Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia", pages = "728-723", number = "5", volume = "26", doi = "10.1038/eye.2012.20" }
Kovačević-Pavićević, D., Radosavljević, A., Ilić, A., Kovačević, I.,& Đurković-Đaković, O.. (2012). Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia. in Eye Nature Publishing Group, London., 26(5), 723-728. https://doi.org/10.1038/eye.2012.20
Kovačević-Pavićević D, Radosavljević A, Ilić A, Kovačević I, Đurković-Đaković O. Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia. in Eye. 2012;26(5):723-728. doi:10.1038/eye.2012.20 .
Kovačević-Pavićević, Dragana, Radosavljević, A., Ilić, Aleksandra, Kovačević, Igor, Đurković-Đaković, Olgica, "Clinical pattern of ocular toxoplasmosis treated in a referral centre in Serbia" in Eye, 26, no. 5 (2012):723-728, https://doi.org/10.1038/eye.2012.20 . .