Distribution of serum phospholipid fractions in patients with diabetes type 2 and dyslipidemia

Abstract

The aim of the present paper was to investigate the serum concentration of total phospholipids and distribution of the phospholipid classes in patients with diabetes mellitus type 2 and dyslipidemia. We analyzed the serum phospholipids in 28 newly diagnosed patients with diabetes type 2, of which 12 men and 16 postmenopausal women aged 43-70 years. Sex- and age-matched control group was formed from 27 apparently healthy subjects. The results showed a significantly higher level of total phospholipids in the patient group when compared with healthy subjects (p lt 0.001). The relative concentration of phosphatidil-choline was significantly higher, and percentages of all other phospholipid classes were significantly lower in the patient group. The obtained results suggest an altered metabolic control of phospholipids in patients with diabetes type 2 with dyslipidemia.

Cilj našeg rada bio je da se odredi koncentracija ukupnih fosfolipida i procentualna zastupljenost fosfolipidnih frakcija u serumu bolesnika sa dijabetesom tip 2 i udruženom dislipidemijom. U studiju je uključeno 28 bolesnika sa novootkrivenim dijabetesom tip 2, od kojih je 12 muškaraca i 16 žena u postmenopauzalnom periodu, starosti 43-70 godina. Kontrolnu grupu činilo je 27 zdravih osoba iste starosti. Rezultati istraživanja su pokazali statistički značajno viši nivo ukupnih fosfolipida u grupi bolesnika u poređenju sa zdravim osobama (p lt 0.001). Procentualna zastupljenost fosfolipidnih frakcija pokazala je statistički značajno veći udeo fosfatidil-holina i statistički značajno nižu učestalost svih ostalih frakcija fosfolipida u grupi obolelih. Dobijeni rezultati ukazuju na poremećenu kontrolu metabolizma fosfolipida kod obolelih od dijabetesa tip 2 sa udruženom dislipidemijom.