Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients
Само за регистроване кориснике
2012
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The relationship between plasma levels of total phospholipids (PL) and/or PL fractions and neoplastic diseases are not fully understood. Therefore, the aim of this study was to analyze concentrations and distribution of plasma phospholipids in patients with prostate cancer (PCa) related to the Gleason score, clinical stage and pathologic grade of prostate cancer. We analyzed plasma phospholipids in 57 newly diagnosed, untreated PCa patients and in 43 age-matched healthy male subjects. Significantly lower (P lt 0.01) levels of total plasma PL and all PL classes were found in PCa patients when compared with healthy subjects. The relative concentrations of PL fractions were also changed. Further decrease of total PL and PL fractions was found related to an increase of clinical stadium, pathologic grade, and Gleason score, with phosphatidylethanolamine as the most sensitive plasma PL, the level of which significantly decreased even at the first stage of PCa. Our results showed an altered... plasma PL profile in PCa patients, which may contribute to monitoring of the disease progression.
Кључне речи:
Plasma phospholipids / Phospholipid classes / Prostate cancerИзвор:
Medical Oncology, 2012, 29, 2, 809-814Издавач:
- Humana Press Inc, Totowa
Финансирање / пројекти:
DOI: 10.1007/s12032-011-9914-z
ISSN: 1357-0560
PubMed: 21442313
WoS: 000303539000064
Scopus: 2-s2.0-84866298536
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Cvetković, B. AU - Vučić, Vesna M. AU - Cvetković, Z. AU - Popović, Tamara B. AU - Glibetić, Marija PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/409 AB - The relationship between plasma levels of total phospholipids (PL) and/or PL fractions and neoplastic diseases are not fully understood. Therefore, the aim of this study was to analyze concentrations and distribution of plasma phospholipids in patients with prostate cancer (PCa) related to the Gleason score, clinical stage and pathologic grade of prostate cancer. We analyzed plasma phospholipids in 57 newly diagnosed, untreated PCa patients and in 43 age-matched healthy male subjects. Significantly lower (P lt 0.01) levels of total plasma PL and all PL classes were found in PCa patients when compared with healthy subjects. The relative concentrations of PL fractions were also changed. Further decrease of total PL and PL fractions was found related to an increase of clinical stadium, pathologic grade, and Gleason score, with phosphatidylethanolamine as the most sensitive plasma PL, the level of which significantly decreased even at the first stage of PCa. Our results showed an altered plasma PL profile in PCa patients, which may contribute to monitoring of the disease progression. PB - Humana Press Inc, Totowa T2 - Medical Oncology T1 - Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients EP - 814 IS - 2 SP - 809 VL - 29 DO - 10.1007/s12032-011-9914-z ER -
@article{ author = "Cvetković, B. and Vučić, Vesna M. and Cvetković, Z. and Popović, Tamara B. and Glibetić, Marija", year = "2012", abstract = "The relationship between plasma levels of total phospholipids (PL) and/or PL fractions and neoplastic diseases are not fully understood. Therefore, the aim of this study was to analyze concentrations and distribution of plasma phospholipids in patients with prostate cancer (PCa) related to the Gleason score, clinical stage and pathologic grade of prostate cancer. We analyzed plasma phospholipids in 57 newly diagnosed, untreated PCa patients and in 43 age-matched healthy male subjects. Significantly lower (P lt 0.01) levels of total plasma PL and all PL classes were found in PCa patients when compared with healthy subjects. The relative concentrations of PL fractions were also changed. Further decrease of total PL and PL fractions was found related to an increase of clinical stadium, pathologic grade, and Gleason score, with phosphatidylethanolamine as the most sensitive plasma PL, the level of which significantly decreased even at the first stage of PCa. Our results showed an altered plasma PL profile in PCa patients, which may contribute to monitoring of the disease progression.", publisher = "Humana Press Inc, Totowa", journal = "Medical Oncology", title = "Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients", pages = "814-809", number = "2", volume = "29", doi = "10.1007/s12032-011-9914-z" }
Cvetković, B., Vučić, V. M., Cvetković, Z., Popović, T. B.,& Glibetić, M.. (2012). Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients. in Medical Oncology Humana Press Inc, Totowa., 29(2), 809-814. https://doi.org/10.1007/s12032-011-9914-z
Cvetković B, Vučić VM, Cvetković Z, Popović TB, Glibetić M. Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients. in Medical Oncology. 2012;29(2):809-814. doi:10.1007/s12032-011-9914-z .
Cvetković, B., Vučić, Vesna M., Cvetković, Z., Popović, Tamara B., Glibetić, Marija, "Systemic alterations in concentrations and distribution of plasma phospholipids in prostate cancer patients" in Medical Oncology, 29, no. 2 (2012):809-814, https://doi.org/10.1007/s12032-011-9914-z . .