Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men
2012
Аутори
Šarac, IvanaBackhouse, Katharine
Shojaee-Moradie, Fariba
Stolinski, Michael
Robertson, Denise M.
Bell, Jimmy D.
Thomas, E. Louise
Hovorka, Roman
Wright, John
Umpleby, A. Margot
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Context: High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol in women. This may be due to gender differences in very-low-density lipoprotein 1 (VLDL1)- and VLDL2-TG and fatty acid kinetics. Objective: Our objective was to investigate whether there are differences in VLDL1- and VLDL2-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease. Research Design and Methods: Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL1-TG and VLDL2-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging. Participants: Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG. Results: The... women had lower visceral fat and higher sc fat than the men (P lt 0.001 and P lt 0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P lt 0.03). VLDL2-TG PR corrected for fat-free mass was higher in the women (P lt 0.001). VLDL2-TG and VLDL2-cholesterol pools were higher in the women (P lt 0.001 and P lt 0.008). VLDL1-TG FCR and PR and VLDL2-TG FCR were not different between genders. Conclusion: Fatty acid and VLDL2-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels. (J Clin Endocrinol Metab 97: 2475-2481, 2012)
Извор:
Journal of Clinical Endocrinology & Metabolism, 2012, 97, 7, 2475-2481Издавач:
- Endocrine Soc, Chevy Chase
Финансирање / пројекти:
- European Foundation for the Study of Diabetes
- University of Surrey
- Overseas Research Students Award Scheme
- UK Research & Innovation (UKRI) Medical Research Council UK (MRC) [G0600717B, MC_U120061305]
DOI: 10.1210/jc.2011-3248
ISSN: 0021-972X
PubMed: 22508714
WoS: 000306286100073
Scopus: 2-s2.0-84863586988
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Šarac, Ivana AU - Backhouse, Katharine AU - Shojaee-Moradie, Fariba AU - Stolinski, Michael AU - Robertson, Denise M. AU - Bell, Jimmy D. AU - Thomas, E. Louise AU - Hovorka, Roman AU - Wright, John AU - Umpleby, A. Margot PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/408 AB - Context: High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol in women. This may be due to gender differences in very-low-density lipoprotein 1 (VLDL1)- and VLDL2-TG and fatty acid kinetics. Objective: Our objective was to investigate whether there are differences in VLDL1- and VLDL2-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease. Research Design and Methods: Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL1-TG and VLDL2-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging. Participants: Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG. Results: The women had lower visceral fat and higher sc fat than the men (P lt 0.001 and P lt 0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P lt 0.03). VLDL2-TG PR corrected for fat-free mass was higher in the women (P lt 0.001). VLDL2-TG and VLDL2-cholesterol pools were higher in the women (P lt 0.001 and P lt 0.008). VLDL1-TG FCR and PR and VLDL2-TG FCR were not different between genders. Conclusion: Fatty acid and VLDL2-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels. (J Clin Endocrinol Metab 97: 2475-2481, 2012) PB - Endocrine Soc, Chevy Chase T2 - Journal of Clinical Endocrinology & Metabolism T1 - Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men EP - 2481 IS - 7 SP - 2475 VL - 97 DO - 10.1210/jc.2011-3248 ER -
@article{ author = "Šarac, Ivana and Backhouse, Katharine and Shojaee-Moradie, Fariba and Stolinski, Michael and Robertson, Denise M. and Bell, Jimmy D. and Thomas, E. Louise and Hovorka, Roman and Wright, John and Umpleby, A. Margot", year = "2012", abstract = "Context: High plasma triglycerides (TG) have been shown to be independent and better predictors of cardiovascular disease than low-density lipoprotein (LDL) cholesterol in women. This may be due to gender differences in very-low-density lipoprotein 1 (VLDL1)- and VLDL2-TG and fatty acid kinetics. Objective: Our objective was to investigate whether there are differences in VLDL1- and VLDL2-TG and fatty acid kinetics in obese men and postmenopausal women, a high risk group for cardiovascular disease. Research Design and Methods: Stable isotopes techniques were used to measure fasting palmitate rate of appearance, metabolic clearance rate, oxidation rate, and nonoxidative disposal rate, VLDL1-TG and VLDL2-TG fractional catabolic rate (FCR) and production rate (PR). Whole-body fat distribution was measured by magnetic resonance imaging. Participants: Participants included 10 postmenopausal obese women and eight obese men matched for age, body mass index, and fasting plasma TG. Results: The women had lower visceral fat and higher sc fat than the men (P lt 0.001 and P lt 0.002). Palmitate rate of appearance, metabolic clearance rate, nonoxidative disposal rate, and oxidation rate corrected for resting energy expenditure were greater in the women than the men (all P lt 0.03). VLDL2-TG PR corrected for fat-free mass was higher in the women (P lt 0.001). VLDL2-TG and VLDL2-cholesterol pools were higher in the women (P lt 0.001 and P lt 0.008). VLDL1-TG FCR and PR and VLDL2-TG FCR were not different between genders. Conclusion: Fatty acid and VLDL2-TG flux is higher in postmenopausal obese women than in obese men matched for fasting plasma TG levels. (J Clin Endocrinol Metab 97: 2475-2481, 2012)", publisher = "Endocrine Soc, Chevy Chase", journal = "Journal of Clinical Endocrinology & Metabolism", title = "Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men", pages = "2481-2475", number = "7", volume = "97", doi = "10.1210/jc.2011-3248" }
Šarac, I., Backhouse, K., Shojaee-Moradie, F., Stolinski, M., Robertson, D. M., Bell, J. D., Thomas, E. L., Hovorka, R., Wright, J.,& Umpleby, A. M.. (2012). Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men. in Journal of Clinical Endocrinology & Metabolism Endocrine Soc, Chevy Chase., 97(7), 2475-2481. https://doi.org/10.1210/jc.2011-3248
Šarac I, Backhouse K, Shojaee-Moradie F, Stolinski M, Robertson DM, Bell JD, Thomas EL, Hovorka R, Wright J, Umpleby AM. Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men. in Journal of Clinical Endocrinology & Metabolism. 2012;97(7):2475-2481. doi:10.1210/jc.2011-3248 .
Šarac, Ivana, Backhouse, Katharine, Shojaee-Moradie, Fariba, Stolinski, Michael, Robertson, Denise M., Bell, Jimmy D., Thomas, E. Louise, Hovorka, Roman, Wright, John, Umpleby, A. Margot, "Gender Differences in VLDL1 and VLDL2 Triglyceride Kinetics and Fatty Acid Kinetics in Obese Postmenopausal Women and Obese Men" in Journal of Clinical Endocrinology & Metabolism, 97, no. 7 (2012):2475-2481, https://doi.org/10.1210/jc.2011-3248 . .