Prikaz osnovnih podataka o dokumentu

dc.creatorPopović, Tamara B.
dc.creatorBorozan, Sunčica
dc.creatorArsić, Aleksandra
dc.creatorMartacić, J. D.
dc.creatorVučić, Vesna M.
dc.creatorTrbović, A.
dc.creatorMandić, Ljuba M.
dc.creatorGlibetić, Marija
dc.date.accessioned2021-04-20T12:28:32Z
dc.date.available2021-04-20T12:28:32Z
dc.date.issued2012
dc.identifier.issn0931-2439
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/405
dc.description.abstractIn the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n-3 FAs and decreasing n-6/n-3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.en
dc.publisherWiley, Hoboken
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41030/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173034/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Animal Physiology & Animal Nutrition
dc.subjectwistar ratsen
dc.subjectfish oilen
dc.subjectliveren
dc.subjectfatty acidsen
dc.subjectoxidative stressen
dc.titleFish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1029
dc.citation.issue6
dc.citation.other96(6): 1020-1029
dc.citation.rankM21
dc.citation.spage1020
dc.citation.volume96
dc.identifier.doi10.1111/j.1439-0396.2011.01216.x
dc.identifier.pmid21883500
dc.identifier.scopus2-s2.0-84869097418
dc.identifier.wos000314234700010
dc.type.versionpublishedVersion


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