In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n-3 FAs and decreasin...g n-6/n-3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.
TY - JOUR
AU - Popović, Tamara B.
AU - Borozan, Sunčica
AU - Arsić, Aleksandra Č.
AU - Martacić, J. D.
AU - Vučić, Vesna M.
AU - Trbović, A.
AU - Mandić, Ljuba M.
AU - Glibetić, Marija
PY - 2012
UR - http://rimi.imi.bg.ac.rs/handle/123456789/405
AB - In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n-3 FAs and decreasing n-6/n-3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.
PB - Wiley, Hoboken
T2 - Journal of Animal Physiology & Animal Nutrition
T1 - Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats
EP - 1029
IS - 6
SP - 1020
VL - 96
DO - 10.1111/j.1439-0396.2011.01216.x
ER -
@article{
author = "Popović, Tamara B. and Borozan, Sunčica and Arsić, Aleksandra Č. and Martacić, J. D. and Vučić, Vesna M. and Trbović, A. and Mandić, Ljuba M. and Glibetić, Marija",
year = "2012",
abstract = "In the present study, we examined the effects of fish oil supplementation in 3 months old male Wistar rats on changes in plasma and liver lipid metabolism and oxidative stress parameters. Twenty Wistar rats were randomly divided into two groups of ten animals: control group and intervention group, treated for 6 weeks with fish oil capsules containing 45 mg eicosapentanoic acid and 30 mg docosahexanoic acid. After intervention, biochemical parameters in plasma [triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and total cholesterol, urea, creatinine and uric acid], fatty acid (FAs) profile of liver phospholipids and parameters of oxidative stress in liver [activity of catalase, superoxide dismutase and paraoxonase (PON1), concentration of nitrites, lipid peroxidation (LPO), free thiol (SH) groups and lactate dehydrogenase (LDH) izoenzymes were determined. Treatment with fish oil improved FAs profile of liver phospholipids, increasing n-3 FAs and decreasing n-6/n-3 ratio. Significant decrease in plasma TG and LDL concentration, and increase in the level of HDL and uric acid were found in intervention group at the end of the study. Catalase activity, LPO, and nitrites concentration in liver were significantly decreased, after the supplementation, together with elevated PON1 activity. Applied treatment significantly improved plasma lipid profile, liver FAs composition and parameters of oxidative stress in male Wistar rats.",
publisher = "Wiley, Hoboken",
journal = "Journal of Animal Physiology & Animal Nutrition",
title = "Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats",
pages = "1029-1020",
number = "6",
volume = "96",
doi = "10.1111/j.1439-0396.2011.01216.x"
}
Popović, T. B., Borozan, S., Arsić, A. Č., Martacić, J. D., Vučić, V. M., Trbović, A., Mandić, L. M.,& Glibetić, M.. (2012). Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats. in Journal of Animal Physiology & Animal Nutrition
Wiley, Hoboken., 96(6), 1020-1029.
https://doi.org/10.1111/j.1439-0396.2011.01216.x
conv_2910
Popović TB, Borozan S, Arsić AČ, Martacić JD, Vučić VM, Trbović A, Mandić LM, Glibetić M. Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats. in Journal of Animal Physiology & Animal Nutrition. 2012;96(6):1020-1029.
doi:10.1111/j.1439-0396.2011.01216.x
conv_2910 .
Popović, Tamara B., Borozan, Sunčica, Arsić, Aleksandra Č., Martacić, J. D., Vučić, Vesna M., Trbović, A., Mandić, Ljuba M., Glibetić, Marija, "Fish oil supplementation improved liver phospholipids fatty acid composition and parameters of oxidative stress in male wistar rats" in Journal of Animal Physiology & Animal Nutrition, 96, no. 6 (2012):1020-1029,
https://doi.org/10.1111/j.1439-0396.2011.01216.x .,
conv_2910 .
