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Effects of il-17 on erythroid progenitors growth: involvement of mapks and gata transcription factors
dc.creator | Krstić, Aleksandra | |
dc.creator | Kocić, Jelena | |
dc.creator | Ilić, Vesna | |
dc.creator | Mojsilović, S. | |
dc.creator | Okić Đorđević, Ivana | |
dc.creator | Trivanović, Drenka | |
dc.creator | Santibanez, Juan F. | |
dc.creator | Jovčić, Gordana | |
dc.creator | Bugarski, Diana | |
dc.date.accessioned | 2021-04-20T12:28:24Z | |
dc.date.available | 2021-04-20T12:28:24Z | |
dc.date.issued | 2012 | |
dc.identifier.issn | 0393-974X | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/403 | |
dc.description.abstract | Interleukin-17 is Th17 cell cytokine implicated in regulation of hematopoiesis and inflammation. Besides promoting granulopoiesis, we have previously shown that IL-17 also affects erythropoiesis stimulating the development of early erythroid progenitors, BFU-E, but suppressing, at least partly via p38 MAPK, the growth of late stage erythroid progenitors, CFU-E. The aim of the present study was to investigate the involvement of other MAPKs, JNK and ERK1/2, as well as GATA transcription factors, in IL-17-mediated effects on murine bone marrow erythroid progenitors. Data obtained by use of specific MAPKs inhibitors indicated that MEK1/2-ERK1/2 MAPK signaling mediates IL-17-induced CFU-E inhibition, as well as that JNK and/or MEK1/2-ERK1/2 MAPKs activation underlies IL-17-induced stimulation of BFU-E growth. Furthermore, Western blot analyses demonstrated no effect on early hematopoiesis transcription factor, GATA-2, and enhanced expression level of erythroid-specific factor GATA-1 in murine bone marrow cells after IL-17 stimulation, which in light of previous reports that GATA-1 overexpression inhibits erythroid differentiation, could be related to IL-17-mediated inhibition of CFU-E growth. Although, no contribution for p38, JNK and ERK MAPKs in IL-17-induced GATA-1 expression was shown, data obtained using specific inhibitors pointed to the role of JNK and MEK1/2-ERK1/2 in GATA-1 downregulation. Overall, obtained data gave an insight into the mechanisms by which IL-17 exerts its effects on erythropoiesis, implying the involvement of JNK and ERK MAPKs, as well as GATA-1, in IL-17-regulated growth of erythroid progentors. | en |
dc.publisher | Biolife Sas, Silva Marina (Te) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Biological Regulators & Homeostatic Agents | |
dc.subject | IL-17 | en |
dc.subject | erythropoiesis | en |
dc.subject | MAPK | en |
dc.subject | GATA | en |
dc.title | Effects of il-17 on erythroid progenitors growth: involvement of mapks and gata transcription factors | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 652 | |
dc.citation.issue | 4 | |
dc.citation.other | 26(4): 641-652 | |
dc.citation.spage | 641 | |
dc.citation.volume | 26 | |
dc.identifier.pmid | 23241114 | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimi_403 | |
dc.identifier.wos | 000313603200007 | |
dc.type.version | publishedVersion |
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