Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
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Zec, Manja M.![](/themes/MirageRIMI/images/orcid.png)
Srdić-Rajić, Tatjana
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Konić-Ristić, Aleksandra
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Todorović, Tamara
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Anđelković, Katarina
![](/themes/MirageRIMI/images/orcid.png)
Filipovic-Ljesković, Ivana
Radulović, Siniša
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Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in ...treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
Keywords:
Antiangiogenic potential / Antiinvasive potential / Antimetastatic potential / Cadmium / Cisplatin / Matrix-metalloproteinase / Metal complexes / Metastasis / Nickel / Oncology / Reactive oxygen species / Selenosemicarbazones / Tubulogenesis / VEGF / ZincSource:
Anti-Cancer Agents in Medicinal Chemistry, 2012, 12, 9, 1071-1080Publisher:
- Bentham Science Publ Ltd, Sharjah
Funding / projects:
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41026)
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-MESTD-Basic Research (BR or ON)-172055)
DOI: 10.2174/187152012803529682
ISSN: 1871-5206
PubMed: 22583413
WoS: 000310055000006
Scopus: 2-s2.0-84872258038
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Institut za medicinska istraživanjaTY - JOUR AU - Zec, Manja M. AU - Srdić-Rajić, Tatjana AU - Konić-Ristić, Aleksandra AU - Todorović, Tamara AU - Anđelković, Katarina AU - Filipovic-Ljesković, Ivana AU - Radulović, Siniša PY - 2012 UR - http://rimi.imi.bg.ac.rs/handle/123456789/391 AB - Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent. PB - Bentham Science Publ Ltd, Sharjah T2 - Anti-Cancer Agents in Medicinal Chemistry T1 - Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones EP - 1080 IS - 9 SP - 1071 VL - 12 DO - 10.2174/187152012803529682 ER -
@article{ author = "Zec, Manja M. and Srdić-Rajić, Tatjana and Konić-Ristić, Aleksandra and Todorović, Tamara and Anđelković, Katarina and Filipovic-Ljesković, Ivana and Radulović, Siniša", year = "2012", abstract = "Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Anti-Cancer Agents in Medicinal Chemistry", title = "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones", pages = "1080-1071", number = "9", volume = "12", doi = "10.2174/187152012803529682" }
Zec, M. M., Srdić-Rajić, T., Konić-Ristić, A., Todorović, T., Anđelković, K., Filipovic-Ljesković, I.,& Radulović, S.. (2012). Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry Bentham Science Publ Ltd, Sharjah., 12(9), 1071-1080. https://doi.org/10.2174/187152012803529682
Zec MM, Srdić-Rajić T, Konić-Ristić A, Todorović T, Anđelković K, Filipovic-Ljesković I, Radulović S. Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry. 2012;12(9):1071-1080. doi:10.2174/187152012803529682 .
Zec, Manja M., Srdić-Rajić, Tatjana, Konić-Ristić, Aleksandra, Todorović, Tamara, Anđelković, Katarina, Filipovic-Ljesković, Ivana, Radulović, Siniša, "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones" in Anti-Cancer Agents in Medicinal Chemistry, 12, no. 9 (2012):1071-1080, https://doi.org/10.2174/187152012803529682 . .