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Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones

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Authors
Zec, Manja M.
Srdić-Rajić, Tatjana
Konić-Ristić, Aleksandra
Todorović, Tamara
Anđelković, Katarina
Filipovic-Ljesković, Ivana
Radulović, Siniša
Article (Published version)
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Abstract
Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in ...treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.

Keywords:
Antiangiogenic potential / Antiinvasive potential / Antimetastatic potential / Cadmium / Cisplatin / Matrix-metalloproteinase / Metal complexes / Metastasis / Nickel / Oncology / Reactive oxygen species / Selenosemicarbazones / Tubulogenesis / VEGF / Zinc
Source:
Anti-Cancer Agents in Medicinal Chemistry, 2012, 12, 9, 1071-1080
Publisher:
  • Bentham Science Publ Ltd, Sharjah
Funding / projects:
  • Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
  • Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)

DOI: 10.2174/187152012803529682

ISSN: 1871-5206

PubMed: 22583413

WoS: 000310055000006

Scopus: 2-s2.0-84872258038
[ Google Scholar ]
26
18
URI
http://rimi.imi.bg.ac.rs/handle/123456789/391
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Zec, Manja M.
AU  - Srdić-Rajić, Tatjana
AU  - Konić-Ristić, Aleksandra
AU  - Todorović, Tamara
AU  - Anđelković, Katarina
AU  - Filipovic-Ljesković, Ivana
AU  - Radulović, Siniša
PY  - 2012
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/391
AB  - Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones
EP  - 1080
IS  - 9
SP  - 1071
VL  - 12
DO  - 10.2174/187152012803529682
UR  - conv_2839
ER  - 
@article{
author = "Zec, Manja M. and Srdić-Rajić, Tatjana and Konić-Ristić, Aleksandra and Todorović, Tamara and Anđelković, Katarina and Filipovic-Ljesković, Ivana and Radulović, Siniša",
year = "2012",
abstract = "Our previous studies showed that zinc (II), cadmium (II) and nickel (II) complexes with 2-formylpyridine selenose-micarbazone induce apoptosis in cancer cells via activation of mitochondrial pathway. Herein, we reported their antimetastatic properties. Nickel (II), and zinc (II) complexes exhibited the strongest inhibitory potential towards MMP-2/9, while all investigated compounds significantly decreased proteolytic activity of MMP-2/9 in human breast cancer MDA-MB-361 cells. As shown by in vitro transmembrane assays, nickel (II) complex was the most effective in inhibiting invasion of MDA-MB-361 cells, while the cadmium (II) complex was the most active in inhibiting HeLa cells invasion. In malignant cells, the complexes inhibited intracellular accumulation of reactive oxygen species, known for its pro-angiogenic properties via VEGF signaling, but no reduction in total cellular amount of VEGF was found. Furthermore, tubulogenesis test showed anti-angiogenic effect of the complexes in treated endothelial cells. Data indicate multiple mechanisms of the complexes' anti-angiogenic properties. In addition, they could modulate metastatic phenotype of tumor cells. Nickel (II) complex with 2-formylpyridine selenosemicarbazone revealed to be the most potent.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones",
pages = "1080-1071",
number = "9",
volume = "12",
doi = "10.2174/187152012803529682",
url = "conv_2839"
}
Zec, M. M., Srdić-Rajić, T., Konić-Ristić, A., Todorović, T., Anđelković, K., Filipovic-Ljesković, I.,& Radulović, S.. (2012). Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 12(9), 1071-1080.
https://doi.org/10.2174/187152012803529682
conv_2839
Zec MM, Srdić-Rajić T, Konić-Ristić A, Todorović T, Anđelković K, Filipovic-Ljesković I, Radulović S. Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones. in Anti-Cancer Agents in Medicinal Chemistry. 2012;12(9):1071-1080.
doi:10.2174/187152012803529682
conv_2839 .
Zec, Manja M., Srdić-Rajić, Tatjana, Konić-Ristić, Aleksandra, Todorović, Tamara, Anđelković, Katarina, Filipovic-Ljesković, Ivana, Radulović, Siniša, "Anti-metastatic and Anti-angiogenic Properties of Potential New Anti-cancer Drugs Based on Metal Complexes of Selenosemicarbazones" in Anti-Cancer Agents in Medicinal Chemistry, 12, no. 9 (2012):1071-1080,
https://doi.org/10.2174/187152012803529682 .,
conv_2839 .

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