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Imported malaria in Belgrade, Serbia, between 2001 and 2009

Authorized Users Only
2011
Authors
Dakić, Zorica
Pelemis, Mijomir
Đurković-Đaković, Olgica
Lavadinović, Lidija
Nikolić, Aleksandra
Stevanović, Goran
Poluga, Jasmina
Ofori-Belić, Irena
Milošević, Branko
Pavlović, Milorad
Article (Published version)
Metadata
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Abstract
Since 2000, travel of Serbian citizens to tropical areas has been slowly but steadily increasing. To determine the epidemiological and clinical characteristics of imported malaria in Serbia, we analyzed clinical history data of all travelers who presented at the Clinic for Infectious and Tropical Diseases in Belgrade after their return from tropical and subtropical areas between 2001 and 2009. The study series involved a total of 2981 travelers, and included both those with (847) and without (2134) health problems. Malaria was diagnosed in 102 cases (3.4% of all travelers; 12.0% of travelers with febrile episodes). Occurring at a rate of 6 to 16 cases per year, it was predominantly imported from Africa (92.2%), particularly from Equatorial Guinea (38.2%) and Nigeria (15.7%). The most frequent reason for travel was work/business. Patients were predominantly (87.3%) male, and the majority (66.7%) was between 40 and 59 years of age. A total of 15 (14.7%) patients took some form of anti-ma...larial chemoprophylaxis. The dominant causative species was Plasmodium falciparum (78), alone (70) or in mixed infection with P. vivax (5) and P. malariae (3). P. vivax, P. ovale and P. malariae as single agents were each identified in 11, 1 and 1 cases, respectively. Of the 11 cases in which the parasite was not detected, six appeared to be true submicroscopic cases. The clinical course of the disease was severe in 13 patients, all with falciparum malaria, of which three (2.9%) died. Rather than for all travelers, in Serbia screening for malaria should be mandatory in all travelers to endemic regions who present with fever irrespective of chemoprophylaxis history. Inadequate sensitivity of conventional diagnostic methods, illustrated by the cases of submicro-scopic malaria, requires introduction of molecular diagnosis in routine practice.

Keywords:
Imported malaria / diagnosis / epidemiology / Serbia
Source:
Wiener Klinische Wochenschrift, 2011, 123, 15-19
Publisher:
  • Springer Wien, Wien
Funding / projects:
  • Control of infections by Apicomplexan pathogens: from novel drug targets to prediction (RS-41019)

DOI: 10.1007/s00508-011-0040-x

ISSN: 0043-5325

PubMed: 21826415

WoS: 000303683900005

Scopus: 2-s2.0-83655163867
[ Google Scholar ]
7
6
URI
http://rimi.imi.bg.ac.rs/handle/123456789/385
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Dakić, Zorica
AU  - Pelemis, Mijomir
AU  - Đurković-Đaković, Olgica
AU  - Lavadinović, Lidija
AU  - Nikolić, Aleksandra
AU  - Stevanović, Goran
AU  - Poluga, Jasmina
AU  - Ofori-Belić, Irena
AU  - Milošević, Branko
AU  - Pavlović, Milorad
PY  - 2011
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/385
AB  - Since 2000, travel of Serbian citizens to tropical areas has been slowly but steadily increasing. To determine the epidemiological and clinical characteristics of imported malaria in Serbia, we analyzed clinical history data of all travelers who presented at the Clinic for Infectious and Tropical Diseases in Belgrade after their return from tropical and subtropical areas between 2001 and 2009. The study series involved a total of 2981 travelers, and included both those with (847) and without (2134) health problems. Malaria was diagnosed in 102 cases (3.4% of all travelers; 12.0% of travelers with febrile episodes). Occurring at a rate of 6 to 16 cases per year, it was predominantly imported from Africa (92.2%), particularly from Equatorial Guinea (38.2%) and Nigeria (15.7%). The most frequent reason for travel was work/business. Patients were predominantly (87.3%) male, and the majority (66.7%) was between 40 and 59 years of age. A total of 15 (14.7%) patients took some form of anti-malarial chemoprophylaxis. The dominant causative species was Plasmodium falciparum (78), alone (70) or in mixed infection with P. vivax (5) and P. malariae (3). P. vivax, P. ovale and P. malariae as single agents were each identified in 11, 1 and 1 cases, respectively. Of the 11 cases in which the parasite was not detected, six appeared to be true submicroscopic cases. The clinical course of the disease was severe in 13 patients, all with falciparum malaria, of which three (2.9%) died. Rather than for all travelers, in Serbia screening for malaria should be mandatory in all travelers to endemic regions who present with fever irrespective of chemoprophylaxis history. Inadequate sensitivity of conventional diagnostic methods, illustrated by the cases of submicro-scopic malaria, requires introduction of molecular diagnosis in routine practice.
PB  - Springer Wien, Wien
T2  - Wiener Klinische Wochenschrift
T1  - Imported malaria in Belgrade, Serbia, between 2001 and 2009
EP  - 19
SP  - 15
VL  - 123
DO  - 10.1007/s00508-011-0040-x
UR  - conv_2740
ER  - 
@article{
author = "Dakić, Zorica and Pelemis, Mijomir and Đurković-Đaković, Olgica and Lavadinović, Lidija and Nikolić, Aleksandra and Stevanović, Goran and Poluga, Jasmina and Ofori-Belić, Irena and Milošević, Branko and Pavlović, Milorad",
year = "2011",
abstract = "Since 2000, travel of Serbian citizens to tropical areas has been slowly but steadily increasing. To determine the epidemiological and clinical characteristics of imported malaria in Serbia, we analyzed clinical history data of all travelers who presented at the Clinic for Infectious and Tropical Diseases in Belgrade after their return from tropical and subtropical areas between 2001 and 2009. The study series involved a total of 2981 travelers, and included both those with (847) and without (2134) health problems. Malaria was diagnosed in 102 cases (3.4% of all travelers; 12.0% of travelers with febrile episodes). Occurring at a rate of 6 to 16 cases per year, it was predominantly imported from Africa (92.2%), particularly from Equatorial Guinea (38.2%) and Nigeria (15.7%). The most frequent reason for travel was work/business. Patients were predominantly (87.3%) male, and the majority (66.7%) was between 40 and 59 years of age. A total of 15 (14.7%) patients took some form of anti-malarial chemoprophylaxis. The dominant causative species was Plasmodium falciparum (78), alone (70) or in mixed infection with P. vivax (5) and P. malariae (3). P. vivax, P. ovale and P. malariae as single agents were each identified in 11, 1 and 1 cases, respectively. Of the 11 cases in which the parasite was not detected, six appeared to be true submicroscopic cases. The clinical course of the disease was severe in 13 patients, all with falciparum malaria, of which three (2.9%) died. Rather than for all travelers, in Serbia screening for malaria should be mandatory in all travelers to endemic regions who present with fever irrespective of chemoprophylaxis history. Inadequate sensitivity of conventional diagnostic methods, illustrated by the cases of submicro-scopic malaria, requires introduction of molecular diagnosis in routine practice.",
publisher = "Springer Wien, Wien",
journal = "Wiener Klinische Wochenschrift",
title = "Imported malaria in Belgrade, Serbia, between 2001 and 2009",
pages = "19-15",
volume = "123",
doi = "10.1007/s00508-011-0040-x",
url = "conv_2740"
}
Dakić, Z., Pelemis, M., Đurković-Đaković, O., Lavadinović, L., Nikolić, A., Stevanović, G., Poluga, J., Ofori-Belić, I., Milošević, B.,& Pavlović, M.. (2011). Imported malaria in Belgrade, Serbia, between 2001 and 2009. in Wiener Klinische Wochenschrift
Springer Wien, Wien., 123, 15-19.
https://doi.org/10.1007/s00508-011-0040-x
conv_2740
Dakić Z, Pelemis M, Đurković-Đaković O, Lavadinović L, Nikolić A, Stevanović G, Poluga J, Ofori-Belić I, Milošević B, Pavlović M. Imported malaria in Belgrade, Serbia, between 2001 and 2009. in Wiener Klinische Wochenschrift. 2011;123:15-19.
doi:10.1007/s00508-011-0040-x
conv_2740 .
Dakić, Zorica, Pelemis, Mijomir, Đurković-Đaković, Olgica, Lavadinović, Lidija, Nikolić, Aleksandra, Stevanović, Goran, Poluga, Jasmina, Ofori-Belić, Irena, Milošević, Branko, Pavlović, Milorad, "Imported malaria in Belgrade, Serbia, between 2001 and 2009" in Wiener Klinische Wochenschrift, 123 (2011):15-19,
https://doi.org/10.1007/s00508-011-0040-x .,
conv_2740 .

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