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dc.creatorIvanov, Milan
dc.creatorMihailović-Stanojević, Nevena
dc.creatorGrujić-Milanović, Jelica
dc.creatorJovović, D.
dc.creatorMiloradović, Zoran
dc.date.accessioned2021-04-20T12:24:28Z
dc.date.available2021-04-20T12:24:28Z
dc.date.issued2011
dc.identifier.issn0231-424X
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/344
dc.description.abstractPatients with pre-existing hypertension are at a particular risk of fatal outcome due to acute renal failure (ARF). We investigate the effects of angiotensin II type-1 receptor blocker (ARB) losartan, on haemodynamics and biochemical parameters in adult male spontaneously hypertensive rats (SHR) with ischemia/reperfusion ARF. SHR were randomly selected in three experimental groups: sham-operated group (SHAM), ARF group, and ARF+LOS group (losartan, 10 mg/kg/b.w. given by infusion during the period of three hours after reperfusion). Beside the improvement of systemic haemodynamics 24 h after reperfusion, losartan significantly increased renal blood flow (RBF: 19.33 +/- 3.29 ml/min/kg vs. 8.03 +/- 1.04 ml/min/kg, p lt 0.05) and decreased renal vascular resistance (RVR) compared to ARF (8.85 +/- 1.21 mmHg x min x kg/ml vs. 19.90 +/- 2.35 mmHg x min x kg/ml, p lt 0.001). Plasma creatinine (Pcr), urea (Pu) and phosphates (Pphos) were significantly reduced in ARF+LOS group compared to ARF group (Pcr: 99.11 +/- 14.56 mu mol/l vs. 242.71 +/- 20.25 mu mol/l, p lt 0.001; Pu: 33.72 +/- 4.69 mmol/l vs. 61.90 +/- 3.93 mmol/l, p lt 0.001; 2.7 +/- 0.42 mmol/l vs. 5.57 +/- 0.61 mmol/l, p lt 0.01). Our results demonstrate that losartan improves systemic and regional haemodynamic and biochemical parameters in hypertension with ARF.en
dc.publisherAkademiai Kiado Zrt, Budapest
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145054/RS//
dc.rightsrestrictedAccess
dc.sourceActa Physiologica Hungarica
dc.subjecthypertensionen
dc.subjectacute renal failureen
dc.subjectlosartanen
dc.subjectrenal haemodynamicsen
dc.subjectcreatinineen
dc.subjectureaen
dc.subjectphosphatesen
dc.titlePrevention of systemic and regional haemodynamic alterations, hypercreatininemia, hyperuremia and hyperphosphatemia by losartan in hypertension with acute renal failureen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage7
dc.citation.issue1
dc.citation.other98(1): 1-7
dc.citation.rankM23
dc.citation.spage1
dc.citation.volume98
dc.identifier.doi10.1556/APhysiol.98.2011.1.1
dc.identifier.pmid21388925
dc.identifier.scopus2-s2.0-79952604602
dc.identifier.wos000288161800001
dc.type.versionpublishedVersion


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