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Prevention of systemic and regional haemodynamic alterations, hypercreatininemia, hyperuremia and hyperphosphatemia by losartan in hypertension with acute renal failure
dc.creator | Ivanov, Milan | |
dc.creator | Mihailović-Stanojević, Nevena | |
dc.creator | Grujić-Milanović, Jelica | |
dc.creator | Jovović, D. | |
dc.creator | Miloradović, Zoran | |
dc.date.accessioned | 2021-04-20T12:24:28Z | |
dc.date.available | 2021-04-20T12:24:28Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 0231-424X | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/344 | |
dc.description.abstract | Patients with pre-existing hypertension are at a particular risk of fatal outcome due to acute renal failure (ARF). We investigate the effects of angiotensin II type-1 receptor blocker (ARB) losartan, on haemodynamics and biochemical parameters in adult male spontaneously hypertensive rats (SHR) with ischemia/reperfusion ARF. SHR were randomly selected in three experimental groups: sham-operated group (SHAM), ARF group, and ARF+LOS group (losartan, 10 mg/kg/b.w. given by infusion during the period of three hours after reperfusion). Beside the improvement of systemic haemodynamics 24 h after reperfusion, losartan significantly increased renal blood flow (RBF: 19.33 +/- 3.29 ml/min/kg vs. 8.03 +/- 1.04 ml/min/kg, p lt 0.05) and decreased renal vascular resistance (RVR) compared to ARF (8.85 +/- 1.21 mmHg x min x kg/ml vs. 19.90 +/- 2.35 mmHg x min x kg/ml, p lt 0.001). Plasma creatinine (Pcr), urea (Pu) and phosphates (Pphos) were significantly reduced in ARF+LOS group compared to ARF group (Pcr: 99.11 +/- 14.56 mu mol/l vs. 242.71 +/- 20.25 mu mol/l, p lt 0.001; Pu: 33.72 +/- 4.69 mmol/l vs. 61.90 +/- 3.93 mmol/l, p lt 0.001; 2.7 +/- 0.42 mmol/l vs. 5.57 +/- 0.61 mmol/l, p lt 0.01). Our results demonstrate that losartan improves systemic and regional haemodynamic and biochemical parameters in hypertension with ARF. | en |
dc.publisher | Akademiai Kiado Zrt, Budapest | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145054/RS// | |
dc.rights | restrictedAccess | |
dc.source | Acta Physiologica Hungarica | |
dc.subject | hypertension | en |
dc.subject | acute renal failure | en |
dc.subject | losartan | en |
dc.subject | renal haemodynamics | en |
dc.subject | creatinine | en |
dc.subject | urea | en |
dc.subject | phosphates | en |
dc.title | Prevention of systemic and regional haemodynamic alterations, hypercreatininemia, hyperuremia and hyperphosphatemia by losartan in hypertension with acute renal failure | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 7 | |
dc.citation.issue | 1 | |
dc.citation.other | 98(1): 1-7 | |
dc.citation.rank | M23 | |
dc.citation.spage | 1 | |
dc.citation.volume | 98 | |
dc.identifier.doi | 10.1556/APhysiol.98.2011.1.1 | |
dc.identifier.pmid | 21388925 | |
dc.identifier.scopus | 2-s2.0-79952604602 | |
dc.identifier.wos | 000288161800001 | |
dc.type.version | publishedVersion |