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Patients with early stage chronic lymphocytic leukemia: new risk stratification based on molecular profiling
dc.creator | Antić, Darko | |
dc.creator | Mihaljević, Biljana | |
dc.creator | Čokić, Vladan | |
dc.creator | Dencic-Fekete, Marija | |
dc.creator | Karan-Đurašević, Teodora | |
dc.creator | Pavlović, Sonja | |
dc.creator | Milić, Nataša | |
dc.creator | Elezović, Ivo | |
dc.date.accessioned | 2021-04-20T12:23:56Z | |
dc.date.available | 2021-04-20T12:23:56Z | |
dc.date.issued | 2011 | |
dc.identifier.issn | 1042-8194 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/336 | |
dc.description.abstract | We investigated molecular and biological parameters reflecting the biology of chronic lymphocytic leukemia (CLL) that may help us to predict the time to first treatment (TTT). A group of 33 patients with newly diagnosed CLL (Binet stage A) were analyzed. We developed a new scoring system based on the serum levels of beta(2)-microglobulin (beta M-2) and vascular endothelial growth factor (VEGF) and the expression of lipoprotein lipase (LPL). Patients with a score of 0 had a TTT of 58.4 months, while patients with a score of 3 (increased levels of beta M-2, LPL, and VEGF) had a significantly shorter TTT of only 10.6 months (p lt 0.0001). | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.rights | restrictedAccess | |
dc.source | Leukemia & Lymphoma | |
dc.subject | Lymphoma and Hodgkin disease | en |
dc.subject | molecular genetics | en |
dc.subject | prognostication | en |
dc.title | Patients with early stage chronic lymphocytic leukemia: new risk stratification based on molecular profiling | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 1397 | |
dc.citation.issue | 7 | |
dc.citation.other | 52(7): 1394-1397 | |
dc.citation.rank | M22 | |
dc.citation.spage | 1394 | |
dc.citation.volume | 52 | |
dc.identifier.doi | 10.3109/10428194.2011.578311 | |
dc.identifier.pmid | 21699385 | |
dc.identifier.scopus | 2-s2.0-79959613190 | |
dc.identifier.wos | 000291992400036 | |
dc.type.version | publishedVersion |