Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats

2011
Authors
Popović, Tamara B.
Borozan, Sunčica

Arsić, Aleksandra Č.

Debeljak-Martačić, Jasmina

Vučić, Vesna M.

De Luka, Silvio R.

Milovanović, Ivan
Trbović, Aleksandar
Glibetić, Marija D.

Article (Published version)
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The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA af...ter supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)
Keywords:
fish oil / aged rats / fatty acids / lipid statusSource:
Croatica Chemica Acta, 2011, 84, 1, 73-79Publisher:
- Croatian Chemical Soc, Zagreb
Funding / projects:
DOI: 10.5562/cca1751
ISSN: 0011-1643
WoS: 000292799300010
Scopus: 2-s2.0-79960203892
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Institut za medicinska istraživanjaTY - JOUR AU - Popović, Tamara B. AU - Borozan, Sunčica AU - Arsić, Aleksandra Č. AU - Debeljak-Martačić, Jasmina AU - Vučić, Vesna M. AU - De Luka, Silvio R. AU - Milovanović, Ivan AU - Trbović, Aleksandar AU - Glibetić, Marija D. PY - 2011 UR - http://rimi.imi.bg.ac.rs/handle/123456789/329 AB - The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751) PB - Croatian Chemical Soc, Zagreb T2 - Croatica Chemica Acta T1 - Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats EP - 79 IS - 1 SP - 73 VL - 84 DO - 10.5562/cca1751 UR - conv_2550 ER -
@article{ author = "Popović, Tamara B. and Borozan, Sunčica and Arsić, Aleksandra Č. and Debeljak-Martačić, Jasmina and Vučić, Vesna M. and De Luka, Silvio R. and Milovanović, Ivan and Trbović, Aleksandar and Glibetić, Marija D.", year = "2011", abstract = "The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)", publisher = "Croatian Chemical Soc, Zagreb", journal = "Croatica Chemica Acta", title = "Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats", pages = "79-73", number = "1", volume = "84", doi = "10.5562/cca1751", url = "conv_2550" }
Popović, T. B., Borozan, S., Arsić, A. Č., Debeljak-Martačić, J., Vučić, V. M., De Luka, S. R., Milovanović, I., Trbović, A.,& Glibetić, M. D.. (2011). Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats. in Croatica Chemica Acta Croatian Chemical Soc, Zagreb., 84(1), 73-79. https://doi.org/10.5562/cca1751 conv_2550
Popović TB, Borozan S, Arsić AČ, Debeljak-Martačić J, Vučić VM, De Luka SR, Milovanović I, Trbović A, Glibetić MD. Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats. in Croatica Chemica Acta. 2011;84(1):73-79. doi:10.5562/cca1751 conv_2550 .
Popović, Tamara B., Borozan, Sunčica, Arsić, Aleksandra Č., Debeljak-Martačić, Jasmina, Vučić, Vesna M., De Luka, Silvio R., Milovanović, Ivan, Trbović, Aleksandar, Glibetić, Marija D., "Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats" in Croatica Chemica Acta, 84, no. 1 (2011):73-79, https://doi.org/10.5562/cca1751 ., conv_2550 .