The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA af...ter supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)
TY - JOUR
AU - Popović, Tamara B.
AU - Borozan, Sunčica
AU - Arsić, Aleksandra Č.
AU - Debeljak-Martačić, Jasmina
AU - Vučić, Vesna M.
AU - De Luka, Silvio R.
AU - Milovanović, Ivan
AU - Trbović, Aleksandar
AU - Glibetić, Marija D.
PY - 2011
UR - http://rimi.imi.bg.ac.rs/handle/123456789/329
AB - The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)
PB - Croatian Chemical Soc, Zagreb
T2 - Croatica Chemica Acta
T1 - Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats
EP - 79
IS - 1
SP - 73
VL - 84
DO - 10.5562/cca1751
UR - conv_2550
ER -
@article{
author = "Popović, Tamara B. and Borozan, Sunčica and Arsić, Aleksandra Č. and Debeljak-Martačić, Jasmina and Vučić, Vesna M. and De Luka, Silvio R. and Milovanović, Ivan and Trbović, Aleksandar and Glibetić, Marija D.",
year = "2011",
abstract = "The effects of fish oil supplementation in Wistar rats are focused on cardiovascular, endocrine, metabolic and antioxidant status changes. We determined plasma and liver phospholipid fatty acids (FAs) status and plasma lipid concentrations in aged Wistar rats. Our results showed differences in plasma and liver FAs profiles as well as plasma chlolesterol (CHOL), triglicerides (TG), high density lipoproteins (HDL), low density lipoproteins (LDL), CHOL/HDL ratio (risk factor for atherosclerosis) and LDL/HDL ratio (risk for cardiovascular diseases) between treated and control group of animals. In fish oil treated group there were statistically significant changes in FAs profile in increasing linoleic acid (LA), dihomo-gamma linoleic acid, eicopentanoic acid (EPA) and docosapentaenoic acid (DPA) and decreasing in arachidonic acid (AA) concentration. Also, liver phospholipids FAs results showed increasing concentrations of vascenic acid, LA, EPA, and DPA and decreasing concentration of AA after supplementation of fish oil compared to control group. However, concentrations of CHOL, LDL and non HDL concentrations decreased while HDL increased in fish oil group. CHOL/HDL, LDL/HDL ratios decreased. These findings suggest that long term treatment of fish oil in aged Wistar rats can be beneficial in decreasing LDL, and decreasing risk factors for developing atherosclerosis and cardiovascular diseases. (doi: 10.5562/cca1751)",
publisher = "Croatian Chemical Soc, Zagreb",
journal = "Croatica Chemica Acta",
title = "Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats",
pages = "79-73",
number = "1",
volume = "84",
doi = "10.5562/cca1751",
url = "conv_2550"
}
Popović, T. B., Borozan, S., Arsić, A. Č., Debeljak-Martačić, J., Vučić, V. M., De Luka, S. R., Milovanović, I., Trbović, A.,& Glibetić, M. D.. (2011). Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats. in Croatica Chemica Acta
Croatian Chemical Soc, Zagreb., 84(1), 73-79.
https://doi.org/10.5562/cca1751
conv_2550
Popović TB, Borozan S, Arsić AČ, Debeljak-Martačić J, Vučić VM, De Luka SR, Milovanović I, Trbović A, Glibetić MD. Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats. in Croatica Chemica Acta. 2011;84(1):73-79.
doi:10.5562/cca1751
conv_2550 .
Popović, Tamara B., Borozan, Sunčica, Arsić, Aleksandra Č., Debeljak-Martačić, Jasmina, Vučić, Vesna M., De Luka, Silvio R., Milovanović, Ivan, Trbović, Aleksandar, Glibetić, Marija D., "Effects of n-3 Supplementation on Plasma and Liver Phospholipid Fatty Acids Profile in Aged Wistar Rats" in Croatica Chemica Acta, 84, no. 1 (2011):73-79,
https://doi.org/10.5562/cca1751 .,
conv_2550 .
