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dc.creatorEshkourfu, Rabia
dc.creatorCobeljić, Bzidar
dc.creatorVujcić, Miroslava
dc.creatorTurel, Iztok
dc.creatorPevec, Andrej
dc.creatorSepcić, Kristina
dc.creatorZec, Manja M.
dc.creatorRadulović, Siniša
dc.creatorSrdić-Rajić, Tatjana
dc.creatorMitić, Dragana
dc.creatorAnđelković, Katarina
dc.creatorSladić, Dušan
dc.date.accessioned2021-04-20T12:23:21Z
dc.date.available2021-04-20T12:23:21Z
dc.date.issued2011
dc.identifier.issn0162-0134
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/327
dc.description.abstractA novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K-b = 4.2 x 10(5) M-1) together with structural analysis of the complex indicate the groove binding.en
dc.publisherElsevier Science Inc, New York
dc.relationSlovenian Research Agency (ARRS) - Slovenia [P1-0175]
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41026/RS//
dc.rightsrestrictedAccess
dc.sourceJournal of Inorganic Biochemistry
dc.subjectDinuclear cobalt(III) complexen
dc.subjectCrystal structureen
dc.subjectApoptosisen
dc.subjectDNA bindingen
dc.titleSynthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazideen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage1203
dc.citation.issue9
dc.citation.other105(9): 1196-1203
dc.citation.rankM21
dc.citation.spage1196
dc.citation.volume105
dc.identifier.doi10.1016/j.jinorgbio.2011.05.024
dc.identifier.pmid21722616
dc.identifier.scopus2-s2.0-79959678170
dc.identifier.wos000294085500011
dc.type.versionpublishedVersion


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Приказ основних података о документу