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Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K-b = 4.2 x 10(5) M-1) together with structural analysis of the complex indicate the groove binding.
TY - JOUR
AU - Eshkourfu, Rabia
AU - Cobeljić, Bzidar
AU - Vujcić, Miroslava
AU - Turel, Iztok
AU - Pevec, Andrej
AU - Sepcić, Kristina
AU - Zec, Manja M.
AU - Radulović, Siniša
AU - Srdić-Rajić, Tatjana
AU - Mitić, Dragana
AU - Anđelković, Katarina
AU - Sladić, Dušan
PY - 2011
UR - http://rimi.imi.bg.ac.rs/handle/123456789/327
AB - A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K-b = 4.2 x 10(5) M-1) together with structural analysis of the complex indicate the groove binding.
PB - Elsevier Science Inc, New York
T2 - Journal of Inorganic Biochemistry
T1 - Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide
EP - 1203
IS - 9
SP - 1196
VL - 105
DO - 10.1016/j.jinorgbio.2011.05.024
UR - conv_2569
ER -
@article{
author = "Eshkourfu, Rabia and Cobeljić, Bzidar and Vujcić, Miroslava and Turel, Iztok and Pevec, Andrej and Sepcić, Kristina and Zec, Manja M. and Radulović, Siniša and Srdić-Rajić, Tatjana and Mitić, Dragana and Anđelković, Katarina and Sladić, Dušan",
year = "2011",
abstract = "A novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide, N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide was synthesized and characterized by elemental analysis, spectroscopy (NMR and infrared), and X-ray crystal analysis. The complex showed a moderate activity towards Artemia salina. The highest cytotoxic potential of the complex was observed on the epithelial breast cancer (MDA-361) cell line. The investigated complex induced apoptosis, the early apoptotic cells comprising 28.18%, compared to 5.64% of control cells in the same phase. The interaction of the complex with calf thymus DNA (CT-DNA) was monitored by blue shift and hyperchromism in the UV-vis spectra. The observed intrinsic binding constant (K-b = 4.2 x 10(5) M-1) together with structural analysis of the complex indicate the groove binding.",
publisher = "Elsevier Science Inc, New York",
journal = "Journal of Inorganic Biochemistry",
title = "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide",
pages = "1203-1196",
number = "9",
volume = "105",
doi = "10.1016/j.jinorgbio.2011.05.024",
url = "conv_2569"
}
Eshkourfu, R., Cobeljić, B., Vujcić, M., Turel, I., Pevec, A., Sepcić, K., Zec, M. M., Radulović, S., Srdić-Rajić, T., Mitić, D., Anđelković, K.,& Sladić, D.. (2011). Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry
Elsevier Science Inc, New York., 105(9), 1196-1203.
https://doi.org/10.1016/j.jinorgbio.2011.05.024
conv_2569
Eshkourfu R, Cobeljić B, Vujcić M, Turel I, Pevec A, Sepcić K, Zec MM, Radulović S, Srdić-Rajić T, Mitić D, Anđelković K, Sladić D. Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide. in Journal of Inorganic Biochemistry. 2011;105(9):1196-1203.
doi:10.1016/j.jinorgbio.2011.05.024
conv_2569 .
Eshkourfu, Rabia, Cobeljić, Bzidar, Vujcić, Miroslava, Turel, Iztok, Pevec, Andrej, Sepcić, Kristina, Zec, Manja M., Radulović, Siniša, Srdić-Rajić, Tatjana, Mitić, Dragana, Anđelković, Katarina, Sladić, Dušan, "Synthesis, characterization, cytotoxic activity and DNA binding properties of the novel dinuclear cobalt(III) complex with the condensation product of 2-acetylpyridine and malonic acid dihydrazide" in Journal of Inorganic Biochemistry, 105, no. 9 (2011):1196-1203,
https://doi.org/10.1016/j.jinorgbio.2011.05.024 .,
conv_2569 .
