Scaling analysis of bilateral hand tremor movements in essential tremor patients
Samo za registrovane korisnike
2011
Autori
Blesić, SuzanaMarić, J.
Dragašević, Nataša
Milanović, Slađan
Kostić, Vladimir S.
Ljubisavljević, Miloš
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Recent evidence suggests that the dynamic-scaling behavior of the time-series of signals extracted from separate peaks of tremor spectra may reveal existence of multiple independent sources of tremor. Here, we have studied dynamic characteristics of the time-series of hand tremor movements in essential tremor (ET) patients using the detrended fluctuation analysis method. Hand accelerometry was recorded with (500 g) and without weight loading under postural conditions in 25 ET patients and 20 normal subjects. The time-series comprising peak-to-peak (PtP) intervals were extracted from regions around the first three main frequency components of power spectra (PwS) of the recorded tremors. The data were compared between the load and no-load condition on dominant (related to tremor severity) and non-dominant tremor side and with the normal (physiological) oscillations in healthy subjects. Our analysis shows that, in ET, the dynamic characteristics of the main frequency component of recorded... tremors exhibit scaling behavior. Furthermore, they show that the two main components of ET tremor frequency spectra, otherwise indistinguishable without load, become significantly different after inertial loading and that they differ between the tremor sides (related to tremor severity). These results show that scaling, a time-domain analysis, helps revealing tremor features previously not revealed by frequency-domain analysis and suggest that distinct oscillatory central circuits may generate the tremor in ET patients.
Ključne reči:
Tremor / Essential tremor / Fourier analysis and DFA method / Load / Tremor asymmetryIzvor:
Journal of Neural Transmission, 2011, 118, 8, 1227-1234Izdavač:
- Springer Wien, Wien
Finansiranje / projekti:
- Fazni prelazi i karakterizacija neorganskih i organskih sistema (RS-MESTD-MPN2006-2010-141020)
- Kortikalna ekscitabilnost i plasticitet kod zdravih ispitanika i pacijenata obolelih od poremećaja motorike – neurofiziološka ispitivanja mehanizama nastanka, mogućnosti modulacije, funkcionalnog i terapijskog značaja (RS-MESTD-MPN2006-2010-145083)
DOI: 10.1007/s00702-011-0581-1
ISSN: 0300-9564
PubMed: 21331462
WoS: 000293244800014
Scopus: 2-s2.0-80051602075
Institucija/grupa
Institut za medicinska istraživanjaTY - JOUR AU - Blesić, Suzana AU - Marić, J. AU - Dragašević, Nataša AU - Milanović, Slađan AU - Kostić, Vladimir S. AU - Ljubisavljević, Miloš PY - 2011 UR - http://rimi.imi.bg.ac.rs/handle/123456789/323 AB - Recent evidence suggests that the dynamic-scaling behavior of the time-series of signals extracted from separate peaks of tremor spectra may reveal existence of multiple independent sources of tremor. Here, we have studied dynamic characteristics of the time-series of hand tremor movements in essential tremor (ET) patients using the detrended fluctuation analysis method. Hand accelerometry was recorded with (500 g) and without weight loading under postural conditions in 25 ET patients and 20 normal subjects. The time-series comprising peak-to-peak (PtP) intervals were extracted from regions around the first three main frequency components of power spectra (PwS) of the recorded tremors. The data were compared between the load and no-load condition on dominant (related to tremor severity) and non-dominant tremor side and with the normal (physiological) oscillations in healthy subjects. Our analysis shows that, in ET, the dynamic characteristics of the main frequency component of recorded tremors exhibit scaling behavior. Furthermore, they show that the two main components of ET tremor frequency spectra, otherwise indistinguishable without load, become significantly different after inertial loading and that they differ between the tremor sides (related to tremor severity). These results show that scaling, a time-domain analysis, helps revealing tremor features previously not revealed by frequency-domain analysis and suggest that distinct oscillatory central circuits may generate the tremor in ET patients. PB - Springer Wien, Wien T2 - Journal of Neural Transmission T1 - Scaling analysis of bilateral hand tremor movements in essential tremor patients EP - 1234 IS - 8 SP - 1227 VL - 118 DO - 10.1007/s00702-011-0581-1 ER -
@article{ author = "Blesić, Suzana and Marić, J. and Dragašević, Nataša and Milanović, Slađan and Kostić, Vladimir S. and Ljubisavljević, Miloš", year = "2011", abstract = "Recent evidence suggests that the dynamic-scaling behavior of the time-series of signals extracted from separate peaks of tremor spectra may reveal existence of multiple independent sources of tremor. Here, we have studied dynamic characteristics of the time-series of hand tremor movements in essential tremor (ET) patients using the detrended fluctuation analysis method. Hand accelerometry was recorded with (500 g) and without weight loading under postural conditions in 25 ET patients and 20 normal subjects. The time-series comprising peak-to-peak (PtP) intervals were extracted from regions around the first three main frequency components of power spectra (PwS) of the recorded tremors. The data were compared between the load and no-load condition on dominant (related to tremor severity) and non-dominant tremor side and with the normal (physiological) oscillations in healthy subjects. Our analysis shows that, in ET, the dynamic characteristics of the main frequency component of recorded tremors exhibit scaling behavior. Furthermore, they show that the two main components of ET tremor frequency spectra, otherwise indistinguishable without load, become significantly different after inertial loading and that they differ between the tremor sides (related to tremor severity). These results show that scaling, a time-domain analysis, helps revealing tremor features previously not revealed by frequency-domain analysis and suggest that distinct oscillatory central circuits may generate the tremor in ET patients.", publisher = "Springer Wien, Wien", journal = "Journal of Neural Transmission", title = "Scaling analysis of bilateral hand tremor movements in essential tremor patients", pages = "1234-1227", number = "8", volume = "118", doi = "10.1007/s00702-011-0581-1" }
Blesić, S., Marić, J., Dragašević, N., Milanović, S., Kostić, V. S.,& Ljubisavljević, M.. (2011). Scaling analysis of bilateral hand tremor movements in essential tremor patients. in Journal of Neural Transmission Springer Wien, Wien., 118(8), 1227-1234. https://doi.org/10.1007/s00702-011-0581-1
Blesić S, Marić J, Dragašević N, Milanović S, Kostić VS, Ljubisavljević M. Scaling analysis of bilateral hand tremor movements in essential tremor patients. in Journal of Neural Transmission. 2011;118(8):1227-1234. doi:10.1007/s00702-011-0581-1 .
Blesić, Suzana, Marić, J., Dragašević, Nataša, Milanović, Slađan, Kostić, Vladimir S., Ljubisavljević, Miloš, "Scaling analysis of bilateral hand tremor movements in essential tremor patients" in Journal of Neural Transmission, 118, no. 8 (2011):1227-1234, https://doi.org/10.1007/s00702-011-0581-1 . .