The mechanisms of the antihypertensive action of heparin in spontaneously hypertensive rats
Нема приказа
Аутори
Jovović, D.Jerkić, Mirjana
Varagić, Jasmina
Veljković, V
Miloradović, Zoran
Marijan, M
Susić, D.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The aim of this study was to examine the effects of heparin on blood pressure in spontaneously hypertensive rats (SHR). Chronic subcutaneous administration of heparin consistenly lowers blood pressure in hypertensive rats. This antihypertensive effect is related at least in part to a concomitant decrease in hematocrit. Spontaneously hypertensive rats were treated with subcutaneous heparin (700U/day) for 6 weeks. At the end of this period we determined cardiac output and total peripheral resistance. Weekly determinations of systolic blood pressure (tail-cuff) and hematocrit were done. Peripheral plasma renin activity, plasma aldosterone, plasma prostaglandins, and urinary kallikrein were measured. Blood pressure responses of acute and chronic heparin treatment to vasoconstrictor substances, including angiotensin I, angiotensin II and norepinephrine, were determined. Heparin produced a significant decrease in hematocrit and a parallel decrease in blood pressure. A significant increase in... plasma renin activity was found in heparin treated SHR, but plasma aldosterone level significantly decreased. Plasma prostaglandins and urinary kallikrein levels were not different among the groups. The blood pressure responses to vasoactive substances were similar among the heparin treated and control groups. The results suggest that a reduced aldosterone level contributes to the antihypertensive mechanism of heparin.
Кључне речи:
heparin / hypertension / renin-angiotensin-aldosterone system / prostaglandins / kallikreinИзвор:
Acta Veterinaria-Beograd, 1997, 47, 4, 211-219Издавач:
- Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Jovović, D. AU - Jerkić, Mirjana AU - Varagić, Jasmina AU - Veljković, V AU - Miloradović, Zoran AU - Marijan, M AU - Susić, D. PY - 1997 UR - http://rimi.imi.bg.ac.rs/handle/123456789/31 AB - The aim of this study was to examine the effects of heparin on blood pressure in spontaneously hypertensive rats (SHR). Chronic subcutaneous administration of heparin consistenly lowers blood pressure in hypertensive rats. This antihypertensive effect is related at least in part to a concomitant decrease in hematocrit. Spontaneously hypertensive rats were treated with subcutaneous heparin (700U/day) for 6 weeks. At the end of this period we determined cardiac output and total peripheral resistance. Weekly determinations of systolic blood pressure (tail-cuff) and hematocrit were done. Peripheral plasma renin activity, plasma aldosterone, plasma prostaglandins, and urinary kallikrein were measured. Blood pressure responses of acute and chronic heparin treatment to vasoconstrictor substances, including angiotensin I, angiotensin II and norepinephrine, were determined. Heparin produced a significant decrease in hematocrit and a parallel decrease in blood pressure. A significant increase in plasma renin activity was found in heparin treated SHR, but plasma aldosterone level significantly decreased. Plasma prostaglandins and urinary kallikrein levels were not different among the groups. The blood pressure responses to vasoactive substances were similar among the heparin treated and control groups. The results suggest that a reduced aldosterone level contributes to the antihypertensive mechanism of heparin. PB - Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd T2 - Acta Veterinaria-Beograd T1 - The mechanisms of the antihypertensive action of heparin in spontaneously hypertensive rats EP - 219 IS - 4 SP - 211 VL - 47 UR - https://hdl.handle.net/21.15107/rcub_rimi_31 ER -
@article{ author = "Jovović, D. and Jerkić, Mirjana and Varagić, Jasmina and Veljković, V and Miloradović, Zoran and Marijan, M and Susić, D.", year = "1997", abstract = "The aim of this study was to examine the effects of heparin on blood pressure in spontaneously hypertensive rats (SHR). Chronic subcutaneous administration of heparin consistenly lowers blood pressure in hypertensive rats. This antihypertensive effect is related at least in part to a concomitant decrease in hematocrit. Spontaneously hypertensive rats were treated with subcutaneous heparin (700U/day) for 6 weeks. At the end of this period we determined cardiac output and total peripheral resistance. Weekly determinations of systolic blood pressure (tail-cuff) and hematocrit were done. Peripheral plasma renin activity, plasma aldosterone, plasma prostaglandins, and urinary kallikrein were measured. Blood pressure responses of acute and chronic heparin treatment to vasoconstrictor substances, including angiotensin I, angiotensin II and norepinephrine, were determined. Heparin produced a significant decrease in hematocrit and a parallel decrease in blood pressure. A significant increase in plasma renin activity was found in heparin treated SHR, but plasma aldosterone level significantly decreased. Plasma prostaglandins and urinary kallikrein levels were not different among the groups. The blood pressure responses to vasoactive substances were similar among the heparin treated and control groups. The results suggest that a reduced aldosterone level contributes to the antihypertensive mechanism of heparin.", publisher = "Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd", journal = "Acta Veterinaria-Beograd", title = "The mechanisms of the antihypertensive action of heparin in spontaneously hypertensive rats", pages = "219-211", number = "4", volume = "47", url = "https://hdl.handle.net/21.15107/rcub_rimi_31" }
Jovović, D., Jerkić, M., Varagić, J., Veljković, V., Miloradović, Z., Marijan, M.,& Susić, D.. (1997). The mechanisms of the antihypertensive action of heparin in spontaneously hypertensive rats. in Acta Veterinaria-Beograd Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd., 47(4), 211-219. https://hdl.handle.net/21.15107/rcub_rimi_31
Jovović D, Jerkić M, Varagić J, Veljković V, Miloradović Z, Marijan M, Susić D. The mechanisms of the antihypertensive action of heparin in spontaneously hypertensive rats. in Acta Veterinaria-Beograd. 1997;47(4):211-219. https://hdl.handle.net/21.15107/rcub_rimi_31 .
Jovović, D., Jerkić, Mirjana, Varagić, Jasmina, Veljković, V, Miloradović, Zoran, Marijan, M, Susić, D., "The mechanisms of the antihypertensive action of heparin in spontaneously hypertensive rats" in Acta Veterinaria-Beograd, 47, no. 4 (1997):211-219, https://hdl.handle.net/21.15107/rcub_rimi_31 .