Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma
Само за регистроване кориснике
2010
Аутори
Cvetković, ZoricaVučić, Vesna M.
Cvetković, Bora
Petrović, Milan
Ristić-Medić, Danijela
Tepšić, Jasna
Glibetić, Marija
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients and in 29 healthy subjects. Significantly higher (p lt 0.001) levels of palmitic (16:0), oleic (18:1 n-9) and arachidonic acids (20:4 n-6), saturated and monounsaturated FA were found in NHL patients, while linoleic acid (18:2 n-6) and the levels of total polyunsaturated FA (PUFA), n-3 PUFA, eicosapentaenoic (20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) were significantly reduced (p lt 0.01). The level of oleic acid in patients with indolent NHL was significantly lower (p lt 0.05) than in more aggressive types of disease. Contents of palmitoleic acid, docosatetraenoic (22:4 n-6), and PUFA was lower in very aggressive NHL. According to ...clinical stage (CS), patients with CS I had significantly higher SFA and lower n-6 FA than other three groups, and group with CS IV showed significantly decreased DHA and n-3 PUFA. Our results showed an abnormal FA profile in serum phospholipids in NHL patients.
Кључне речи:
Fatty acids / Serum phospholipids / Non-Hodgkin lymphomaИзвор:
Annals of Hematology, 2010, 89, 8, 775-782Издавач:
- Springer, New York
Финансирање / пројекти:
- Развој нових терапијских поступака у превенцији и лечењу болести јетре: Улога и механизам деловања полинезасићених масних киселина (RS-MESTD-MPN2006-2010-145071)
DOI: 10.1007/s00277-010-0904-6
ISSN: 0939-5555
PubMed: 20127484
WoS: 000278929400004
Scopus: 2-s2.0-77954662882
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Cvetković, Zorica AU - Vučić, Vesna M. AU - Cvetković, Bora AU - Petrović, Milan AU - Ristić-Medić, Danijela AU - Tepšić, Jasna AU - Glibetić, Marija PY - 2010 UR - http://rimi.imi.bg.ac.rs/handle/123456789/296 AB - The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients and in 29 healthy subjects. Significantly higher (p lt 0.001) levels of palmitic (16:0), oleic (18:1 n-9) and arachidonic acids (20:4 n-6), saturated and monounsaturated FA were found in NHL patients, while linoleic acid (18:2 n-6) and the levels of total polyunsaturated FA (PUFA), n-3 PUFA, eicosapentaenoic (20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) were significantly reduced (p lt 0.01). The level of oleic acid in patients with indolent NHL was significantly lower (p lt 0.05) than in more aggressive types of disease. Contents of palmitoleic acid, docosatetraenoic (22:4 n-6), and PUFA was lower in very aggressive NHL. According to clinical stage (CS), patients with CS I had significantly higher SFA and lower n-6 FA than other three groups, and group with CS IV showed significantly decreased DHA and n-3 PUFA. Our results showed an abnormal FA profile in serum phospholipids in NHL patients. PB - Springer, New York T2 - Annals of Hematology T1 - Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma EP - 782 IS - 8 SP - 775 VL - 89 DO - 10.1007/s00277-010-0904-6 ER -
@article{ author = "Cvetković, Zorica and Vučić, Vesna M. and Cvetković, Bora and Petrović, Milan and Ristić-Medić, Danijela and Tepšić, Jasna and Glibetić, Marija", year = "2010", abstract = "The data about the fatty acid (FA) status of non-Hodgkin lymphoma (NHL) patients are poor. Therefore, the aim of this study was to investigate the FA profile of serum phospholipids in NHL patients related to the aggressiveness and clinical stage of NHL. We analyzed the FA profile of serum phospholipids in 47 newly diagnosed, untreated NHL patients and in 29 healthy subjects. Significantly higher (p lt 0.001) levels of palmitic (16:0), oleic (18:1 n-9) and arachidonic acids (20:4 n-6), saturated and monounsaturated FA were found in NHL patients, while linoleic acid (18:2 n-6) and the levels of total polyunsaturated FA (PUFA), n-3 PUFA, eicosapentaenoic (20:5 n-3) and docosahexaenoic (DHA, 22:6 n-3) were significantly reduced (p lt 0.01). The level of oleic acid in patients with indolent NHL was significantly lower (p lt 0.05) than in more aggressive types of disease. Contents of palmitoleic acid, docosatetraenoic (22:4 n-6), and PUFA was lower in very aggressive NHL. According to clinical stage (CS), patients with CS I had significantly higher SFA and lower n-6 FA than other three groups, and group with CS IV showed significantly decreased DHA and n-3 PUFA. Our results showed an abnormal FA profile in serum phospholipids in NHL patients.", publisher = "Springer, New York", journal = "Annals of Hematology", title = "Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma", pages = "782-775", number = "8", volume = "89", doi = "10.1007/s00277-010-0904-6" }
Cvetković, Z., Vučić, V. M., Cvetković, B., Petrović, M., Ristić-Medić, D., Tepšić, J.,& Glibetić, M.. (2010). Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma. in Annals of Hematology Springer, New York., 89(8), 775-782. https://doi.org/10.1007/s00277-010-0904-6
Cvetković Z, Vučić VM, Cvetković B, Petrović M, Ristić-Medić D, Tepšić J, Glibetić M. Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma. in Annals of Hematology. 2010;89(8):775-782. doi:10.1007/s00277-010-0904-6 .
Cvetković, Zorica, Vučić, Vesna M., Cvetković, Bora, Petrović, Milan, Ristić-Medić, Danijela, Tepšić, Jasna, Glibetić, Marija, "Abnormal fatty acid distribution of the serum phospholipids of patients with non-Hodgkin lymphoma" in Annals of Hematology, 89, no. 8 (2010):775-782, https://doi.org/10.1007/s00277-010-0904-6 . .