Anaplasma phagocytophilum strains from different geographical regions are characterised by diverse potential infectivity for humans and domesticated animals. We investigated the potential pathogenicity of A. phagocytophilum strains in Ixodes ricinus ticks from 11 geographically different localities in Serbia. Sequences obtained in this study showed a high variability of p44 paralogues. Some of them, however, formed groups with similarities greater than 86% ('similarity groups'). Previous studies showed that 'similarity groups' were nearly always country specific. Our results correlated with this observation, and we also observed significant clustering of paralogues according to vector and reservoir origin of A. phagocytophilum strains. According to the high genetic similarity of sequences isolated from ticks collected in four localities, namely Avala, Batrovci, Hajducka cesma and Ljubovija, with paralogues with proven pathogenicity isolated from human granulocytic anaplasmosis (HGA) pa...tients and A. phagocytophilum infected sheep, we could assume that strains with potential infectivity for humans and domestic animals were present in Serbia.
TY - JOUR
AU - Tomanović, Snežana
AU - Radulović, Željko
AU - Masuzawa, Toshiyuki
AU - Milutinović, Marija
AU - Stanisavljević, Ljubiša
PY - 2010
UR - http://rimi.imi.bg.ac.rs/handle/123456789/293
AB - Anaplasma phagocytophilum strains from different geographical regions are characterised by diverse potential infectivity for humans and domesticated animals. We investigated the potential pathogenicity of A. phagocytophilum strains in Ixodes ricinus ticks from 11 geographically different localities in Serbia. Sequences obtained in this study showed a high variability of p44 paralogues. Some of them, however, formed groups with similarities greater than 86% ('similarity groups'). Previous studies showed that 'similarity groups' were nearly always country specific. Our results correlated with this observation, and we also observed significant clustering of paralogues according to vector and reservoir origin of A. phagocytophilum strains. According to the high genetic similarity of sequences isolated from ticks collected in four localities, namely Avala, Batrovci, Hajducka cesma and Ljubovija, with paralogues with proven pathogenicity isolated from human granulocytic anaplasmosis (HGA) patients and A. phagocytophilum infected sheep, we could assume that strains with potential infectivity for humans and domestic animals were present in Serbia.
PB - Akademiai Kiado Zrt, Budapest
T2 - Acta Veterinaria Hungarica
T1 - Potential infectivity of anaplasma phagocytophilum strains in ixodes ricinus ticks from Serbia
EP - 242
IS - 2
SP - 231
VL - 58
DO - 10.1556/AVet.58.2010.2.9
UR - conv_2287
ER -
@article{
author = "Tomanović, Snežana and Radulović, Željko and Masuzawa, Toshiyuki and Milutinović, Marija and Stanisavljević, Ljubiša",
year = "2010",
abstract = "Anaplasma phagocytophilum strains from different geographical regions are characterised by diverse potential infectivity for humans and domesticated animals. We investigated the potential pathogenicity of A. phagocytophilum strains in Ixodes ricinus ticks from 11 geographically different localities in Serbia. Sequences obtained in this study showed a high variability of p44 paralogues. Some of them, however, formed groups with similarities greater than 86% ('similarity groups'). Previous studies showed that 'similarity groups' were nearly always country specific. Our results correlated with this observation, and we also observed significant clustering of paralogues according to vector and reservoir origin of A. phagocytophilum strains. According to the high genetic similarity of sequences isolated from ticks collected in four localities, namely Avala, Batrovci, Hajducka cesma and Ljubovija, with paralogues with proven pathogenicity isolated from human granulocytic anaplasmosis (HGA) patients and A. phagocytophilum infected sheep, we could assume that strains with potential infectivity for humans and domestic animals were present in Serbia.",
publisher = "Akademiai Kiado Zrt, Budapest",
journal = "Acta Veterinaria Hungarica",
title = "Potential infectivity of anaplasma phagocytophilum strains in ixodes ricinus ticks from Serbia",
pages = "242-231",
number = "2",
volume = "58",
doi = "10.1556/AVet.58.2010.2.9",
url = "conv_2287"
}
Tomanović, S., Radulović, Ž., Masuzawa, T., Milutinović, M.,& Stanisavljević, L.. (2010). Potential infectivity of anaplasma phagocytophilum strains in ixodes ricinus ticks from Serbia. in Acta Veterinaria Hungarica
Akademiai Kiado Zrt, Budapest., 58(2), 231-242.
https://doi.org/10.1556/AVet.58.2010.2.9
conv_2287
Tomanović S, Radulović Ž, Masuzawa T, Milutinović M, Stanisavljević L. Potential infectivity of anaplasma phagocytophilum strains in ixodes ricinus ticks from Serbia. in Acta Veterinaria Hungarica. 2010;58(2):231-242.
doi:10.1556/AVet.58.2010.2.9
conv_2287 .
Tomanović, Snežana, Radulović, Željko, Masuzawa, Toshiyuki, Milutinović, Marija, Stanisavljević, Ljubiša, "Potential infectivity of anaplasma phagocytophilum strains in ixodes ricinus ticks from Serbia" in Acta Veterinaria Hungarica, 58, no. 2 (2010):231-242,
https://doi.org/10.1556/AVet.58.2010.2.9 .,
conv_2287 .
