Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1 Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecuti...ve daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days.
Keywords:
Repetitive transcranial magnetic stimulation / rTMS / Parkinson's disease / Placebo / Motor symptoms
Source:
Journal of the Neurological Sciences, 2010, 291, 1-2, 1-4
Publisher:
Elsevier Science Bv, Amsterdam
Funding / projects:
Parkinson's Disease Society of the United Kingdom [4034]
TY - JOUR
AU - Filipović, Saša
AU - Rothwell, John C.
AU - Bhatia, Kailash
PY - 2010
UR - http://rimi.imi.bg.ac.rs/handle/123456789/290
AB - Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1 Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecutive daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days.
PB - Elsevier Science Bv, Amsterdam
T2 - Journal of the Neurological Sciences
T1 - Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease
EP - 4
IS - 1-2
SP - 1
VL - 291
DO - 10.1016/j.jns.2010.01.017
UR - conv_2275
ER -
@article{
author = "Filipović, Saša and Rothwell, John C. and Bhatia, Kailash",
year = "2010",
abstract = "Repetitive transcranial magnetic stimulation (rTMS) can modulate cortical excitability and activation and consequently may affect clinical symptoms in neurological conditions characterized by altered motor cortex functions. There are conflicting reports whether low-frequency rTMS has any clinical effects in Parkinson's disease (PD). Ten patients with PD had rTMS (1800 stimuli at just below active motor threshold intensity) at 1 Hz rate delivered over the motor cortex for four consecutive days on two separate occasions. On one of these real rTMS was used and on the other sham rTMS (placebo) was used. Evaluations with UPDRS Part 3 (Motor Scale) were done in practically defined off-phase at the baseline and one day after the end of each of the treatment series. Neither total Motor Scale scores nor subscores for axial symptoms, rigidity, bradykinesia, and tremor showed any significant difference. The results do not confirm presence of residual beneficial clinical after-effects of consecutive daily applications of low-frequency rTMS on motor symptoms in PD, at least when 1800 stimuli at subthreshold intensity are applied for four days.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Journal of the Neurological Sciences",
title = "Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease",
pages = "4-1",
number = "1-2",
volume = "291",
doi = "10.1016/j.jns.2010.01.017",
url = "conv_2275"
}
Filipović, S., Rothwell, J. C.,& Bhatia, K.. (2010). Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease. in Journal of the Neurological Sciences
Elsevier Science Bv, Amsterdam., 291(1-2), 1-4.
https://doi.org/10.1016/j.jns.2010.01.017
conv_2275
Filipović S, Rothwell JC, Bhatia K. Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease. in Journal of the Neurological Sciences. 2010;291(1-2):1-4.
doi:10.1016/j.jns.2010.01.017
conv_2275 .
Filipović, Saša, Rothwell, John C., Bhatia, Kailash, "Low-frequency repetitive transcranial magnetic stimulation and off-phase motor symptoms in Parkinson's disease" in Journal of the Neurological Sciences, 291, no. 1-2 (2010):1-4,
https://doi.org/10.1016/j.jns.2010.01.017 .,
conv_2275 .
