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SKIP is required for TGF-beta 1-induced epithelial mesenchymal transition and migration in transformed keratinocytes
dc.creator | Villar, Victor | |
dc.creator | Kocić, Jelena | |
dc.creator | Bugarski, Diana | |
dc.creator | Jovčić, Gordana | |
dc.creator | Santibanez, Juan F. | |
dc.date.accessioned | 2021-04-20T12:20:41Z | |
dc.date.available | 2021-04-20T12:20:41Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 1873-3468 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/287 | |
dc.description.abstract | Transforming growth factor-beta 1 (TGF-beta 1) potently induces the epithelial-mesenchymal transition (EMT) during tumoral progression. Although Sky-interacting protein (SKIP) regulates TGF-beta 1-induced Smad activation, its role in the induction of cell malignance remains uncertain. We found that TGF-beta 1 increases SKIP expression in PDV cells. In cells stably transfected with SKIP antisense, AS-S, Smad3 activation decreased, along with an inhibition of TGF-beta 1-induced EMT, and the cells were sensitized to the TGF-beta 1-dependent inhibition of proliferation. Also, AS-S cells showed a weaker migration and invasion response. Moreover, TGF-beta 1-induced urokinase-type plasminogen activator expression was inhibited, concomitantly with a TGF-beta 1-independent increment of the plasminogen-activator inhibitor-1 expression. Thus, these results suggest that SKIP is required for EMT and invasiveness induced by TGF-beta 1 in transformed cells. | en |
dc.publisher | Wiley, Hoboken | |
dc.relation | Chile Comision Nacional de Investigacion Cientifica y Tecnologica FONDECYT [1050476] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175062/RS// | |
dc.rights | openAccess | |
dc.source | FEBS Letters | |
dc.subject | Transforming growth factor-beta 1 | en |
dc.subject | Sky-interacting protein | en |
dc.subject | Epithelial-mesenchymal transition | en |
dc.subject | Urokinase type plasminogen activator | en |
dc.subject | Plasminogen activator inhibitor type-1 | en |
dc.subject | Migration | en |
dc.title | SKIP is required for TGF-beta 1-induced epithelial mesenchymal transition and migration in transformed keratinocytes | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 4592 | |
dc.citation.issue | 22 | |
dc.citation.other | 584(22): 4586-4592 | |
dc.citation.spage | 4586 | |
dc.citation.volume | 584 | |
dc.identifier.doi | 10.1016/j.febslet.2010.10.020 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/232/284.pdf | |
dc.identifier.pmid | 20965173 | |
dc.identifier.scopus | 2-s2.0-78249232622 | |
dc.identifier.wos | 000284148000016 | |
dc.type.version | publishedVersion |