Приказ основних података о документу

dc.creatorMilovanović, Ivan
dc.creatorVujanić, Marija
dc.creatorKlun, Ivana
dc.creatorBobić, Branko
dc.creatorNikolić, Aleksandra
dc.creatorIvović, Vladimir
dc.creatorTrbovich, Alexander M.
dc.creatorĐurković-Đaković, Olgica
dc.date.accessioned2021-04-20T12:18:22Z
dc.date.available2021-04-20T12:18:22Z
dc.date.issued2009
dc.identifier.issn0074-0276
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/253
dc.description.abstractHost lipids have been implicated in the pathogenesis of Toxoplasma gondii infection. To determine if Toxoplasma infection influences the lipid status in the normal host, we assessed serum lipids of Swiss-Webster mice during infection with the BGD-1 strain (type-2) at a series of time points. Mice were bled at days zero and 42 post-infection, and subgroups were additionally bled on alternating weeks (model 1), or sacrificed at days zero, 14 and 42 (model 2) for the measurement of total cholesterol (Chl), high density lipoproteins (HDL), low density lipoproteins (LDL) and triglycerides and adiponectin. At day 42, brains were harvested for cyst enumeration. A significant decrease (p = 0.02) in HDL and total Chl was first noted in infected vs. control mice at day 14 and persisted to day 42 (p = 0.013). Conversely, LDL was unaltered until day 42, when it increased (p = 0.043). Serum LDL levels at day 42 correlated only with cyst counts of above 300 (found in 44% mice), while the change in HDL between days zero and 42 correlated with both the overall mean cyst count (p - 0.041) and cyst counts above 300 (p - 0.044). Calculated per cyst, this decrease in HDL in individual animals ranged from 0.1-17 mu mol/L, with a mean of 2.43 +/- 4.14 mu mol/L. Serum adiponectin levels remained similar between infected and control mice throughout the experiment.en
dc.publisherFundaco Oswaldo Cruz, Rio De Janeiro, Rj
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145002/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMemorias do Instituto Oswaldo Cruz
dc.subjecttoxoplasmosisen
dc.subjectmurine infectionen
dc.subjectlipid metabolismen
dc.subjectcholesterolen
dc.subjectadiponectinen
dc.titleToxoplasma gondii infection induces lipid metabolism alterations in the murine hosten
dc.typearticle
dc.rights.licenseBY
dc.citation.epage178
dc.citation.issue2
dc.citation.other104(2): 175-178
dc.citation.rankM22
dc.citation.spage175
dc.citation.volume104
dc.identifier.doi10.1590/S0074-02762009000200008
dc.identifier.fulltexthttp://rimi.imi.bg.ac.rs/bitstream/id/202/250.pdf
dc.identifier.pmid19430640
dc.identifier.scopus2-s2.0-65549100998
dc.identifier.wos000267051500008
dc.type.versionpublishedVersion


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Приказ основних података о документу