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The Prognosis of Pediatric AIDS in Serbia

Authorized Users Only
2009
Authors
Jevtović, Đorđe
Salemović, Dubravka
Ranin, Jovan
Brmbolić, Branko
Đurković-Đaković, Olgica
Article (Published version)
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Abstract
To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72.6 +/- 44 months, a favorable response was recorded in 62.5%, treatment failure (defined as non-achievement of undetectable viremia) in 20.8%, and a discrepant virological and immunological response (achievement of undetectable viremia but without a rise in CD4 cell counts adequate for age) in 16.7% patients. No patients died, and there were only three hospital admissions after commencing HAART. Five immune restoration inflammatory syndrome episodes were recorded, of which f...our were due to BCG-osis. Lipodystrophy and hyperlipidemia occurred in 18.2% and 26.3% patients, respectively. We conclude that even in suboptimal facilities, the prognosis of HIV disease among children on HAART may be rather good. The metabolic syndrome seems to emerge as an important issue among long-term surviving children on HAART.

Keywords:
Pediatric HIV/AIDS / HAART / Prognosis
Source:
Current HIV Research, 2009, 7, 3, 287-292
Publisher:
  • Bentham Science Publ Ltd, Sharjah
Funding / projects:
  • Infekcije intercelularnim mikroorganizmima rastućeg značaja: transmisija, odnos patogen-domaćin, molekularna epidemiologija i klinički značaj (RS-145002)

DOI: 10.2174/157016209788347912

ISSN: 1570-162X

PubMed: 19442124

WoS: 000267014100006

Scopus: 2-s2.0-67649099433
[ Google Scholar ]
3
3
URI
http://rimi.imi.bg.ac.rs/handle/123456789/252
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Jevtović, Đorđe
AU  - Salemović, Dubravka
AU  - Ranin, Jovan
AU  - Brmbolić, Branko
AU  - Đurković-Đaković, Olgica
PY  - 2009
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/252
AB  - To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72.6 +/- 44 months, a favorable response was recorded in 62.5%, treatment failure (defined as non-achievement of undetectable viremia) in 20.8%, and a discrepant virological and immunological response (achievement of undetectable viremia but without a rise in CD4 cell counts adequate for age) in 16.7% patients. No patients died, and there were only three hospital admissions after commencing HAART. Five immune restoration inflammatory syndrome episodes were recorded, of which four were due to BCG-osis. Lipodystrophy and hyperlipidemia occurred in 18.2% and 26.3% patients, respectively. We conclude that even in suboptimal facilities, the prognosis of HIV disease among children on HAART may be rather good. The metabolic syndrome seems to emerge as an important issue among long-term surviving children on HAART.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current HIV Research
T1  - The Prognosis of Pediatric AIDS in Serbia
EP  - 292
IS  - 3
SP  - 287
VL  - 7
DO  - 10.2174/157016209788347912
UR  - conv_2112
ER  - 
@article{
author = "Jevtović, Đorđe and Salemović, Dubravka and Ranin, Jovan and Brmbolić, Branko and Đurković-Đaković, Olgica",
year = "2009",
abstract = "To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72.6 +/- 44 months, a favorable response was recorded in 62.5%, treatment failure (defined as non-achievement of undetectable viremia) in 20.8%, and a discrepant virological and immunological response (achievement of undetectable viremia but without a rise in CD4 cell counts adequate for age) in 16.7% patients. No patients died, and there were only three hospital admissions after commencing HAART. Five immune restoration inflammatory syndrome episodes were recorded, of which four were due to BCG-osis. Lipodystrophy and hyperlipidemia occurred in 18.2% and 26.3% patients, respectively. We conclude that even in suboptimal facilities, the prognosis of HIV disease among children on HAART may be rather good. The metabolic syndrome seems to emerge as an important issue among long-term surviving children on HAART.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current HIV Research",
title = "The Prognosis of Pediatric AIDS in Serbia",
pages = "292-287",
number = "3",
volume = "7",
doi = "10.2174/157016209788347912",
url = "conv_2112"
}
Jevtović, Đ., Salemović, D., Ranin, J., Brmbolić, B.,& Đurković-Đaković, O.. (2009). The Prognosis of Pediatric AIDS in Serbia. in Current HIV Research
Bentham Science Publ Ltd, Sharjah., 7(3), 287-292.
https://doi.org/10.2174/157016209788347912
conv_2112
Jevtović Đ, Salemović D, Ranin J, Brmbolić B, Đurković-Đaković O. The Prognosis of Pediatric AIDS in Serbia. in Current HIV Research. 2009;7(3):287-292.
doi:10.2174/157016209788347912
conv_2112 .
Jevtović, Đorđe, Salemović, Dubravka, Ranin, Jovan, Brmbolić, Branko, Đurković-Đaković, Olgica, "The Prognosis of Pediatric AIDS in Serbia" in Current HIV Research, 7, no. 3 (2009):287-292,
https://doi.org/10.2174/157016209788347912 .,
conv_2112 .

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