The Prognosis of Pediatric AIDS in Serbia
Abstract
To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72.6 +/- 44 months, a favorable response was recorded in 62.5%, treatment failure (defined as non-achievement of undetectable viremia) in 20.8%, and a discrepant virological and immunological response (achievement of undetectable viremia but without a rise in CD4 cell counts adequate for age) in 16.7% patients. No patients died, and there were only three hospital admissions after commencing HAART. Five immune restoration inflammatory syndrome episodes were recorded, of which f...our were due to BCG-osis. Lipodystrophy and hyperlipidemia occurred in 18.2% and 26.3% patients, respectively. We conclude that even in suboptimal facilities, the prognosis of HIV disease among children on HAART may be rather good. The metabolic syndrome seems to emerge as an important issue among long-term surviving children on HAART.
Keywords:
Pediatric HIV/AIDS / HAART / PrognosisSource:
Current HIV Research, 2009, 7, 3, 287-292Publisher:
- Bentham Science Publ Ltd, Sharjah
Funding / projects:
DOI: 10.2174/157016209788347912
ISSN: 1570-162X
PubMed: 19442124
WoS: 000267014100006
Scopus: 2-s2.0-67649099433
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Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Jevtović, Đorđe AU - Salemović, Dubravka AU - Ranin, Jovan AU - Brmbolić, Branko AU - Đurković-Đaković, Olgica PY - 2009 UR - http://rimi.imi.bg.ac.rs/handle/123456789/252 AB - To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72.6 +/- 44 months, a favorable response was recorded in 62.5%, treatment failure (defined as non-achievement of undetectable viremia) in 20.8%, and a discrepant virological and immunological response (achievement of undetectable viremia but without a rise in CD4 cell counts adequate for age) in 16.7% patients. No patients died, and there were only three hospital admissions after commencing HAART. Five immune restoration inflammatory syndrome episodes were recorded, of which four were due to BCG-osis. Lipodystrophy and hyperlipidemia occurred in 18.2% and 26.3% patients, respectively. We conclude that even in suboptimal facilities, the prognosis of HIV disease among children on HAART may be rather good. The metabolic syndrome seems to emerge as an important issue among long-term surviving children on HAART. PB - Bentham Science Publ Ltd, Sharjah T2 - Current HIV Research T1 - The Prognosis of Pediatric AIDS in Serbia EP - 292 IS - 3 SP - 287 VL - 7 DO - 10.2174/157016209788347912 UR - conv_2112 ER -
@article{ author = "Jevtović, Đorđe and Salemović, Dubravka and Ranin, Jovan and Brmbolić, Branko and Đurković-Đaković, Olgica", year = "2009", abstract = "To determine the outcome of HIV infection in children in a resource-limited setting, a retrospective analysis of a series of 51 pediatric cases from the Serbian cohort of HIV infected patients was performed. Twenty seven patients died in the pre-HAART era, but mono/dual antiretroviral treatment had significantly (p=0.046) prolonged survival. Of the total of 24 HAART-treated patients, 10 had clinical AIDS before HAART initiation. The mean baseline CD4 cell count was 193.9 +/- 170.0/mm(3). After a mean follow-up of 72.6 +/- 44 months, a favorable response was recorded in 62.5%, treatment failure (defined as non-achievement of undetectable viremia) in 20.8%, and a discrepant virological and immunological response (achievement of undetectable viremia but without a rise in CD4 cell counts adequate for age) in 16.7% patients. No patients died, and there were only three hospital admissions after commencing HAART. Five immune restoration inflammatory syndrome episodes were recorded, of which four were due to BCG-osis. Lipodystrophy and hyperlipidemia occurred in 18.2% and 26.3% patients, respectively. We conclude that even in suboptimal facilities, the prognosis of HIV disease among children on HAART may be rather good. The metabolic syndrome seems to emerge as an important issue among long-term surviving children on HAART.", publisher = "Bentham Science Publ Ltd, Sharjah", journal = "Current HIV Research", title = "The Prognosis of Pediatric AIDS in Serbia", pages = "292-287", number = "3", volume = "7", doi = "10.2174/157016209788347912", url = "conv_2112" }
Jevtović, Đ., Salemović, D., Ranin, J., Brmbolić, B.,& Đurković-Đaković, O.. (2009). The Prognosis of Pediatric AIDS in Serbia. in Current HIV Research Bentham Science Publ Ltd, Sharjah., 7(3), 287-292. https://doi.org/10.2174/157016209788347912 conv_2112
Jevtović Đ, Salemović D, Ranin J, Brmbolić B, Đurković-Đaković O. The Prognosis of Pediatric AIDS in Serbia. in Current HIV Research. 2009;7(3):287-292. doi:10.2174/157016209788347912 conv_2112 .
Jevtović, Đorđe, Salemović, Dubravka, Ranin, Jovan, Brmbolić, Branko, Đurković-Đaković, Olgica, "The Prognosis of Pediatric AIDS in Serbia" in Current HIV Research, 7, no. 3 (2009):287-292, https://doi.org/10.2174/157016209788347912 ., conv_2112 .