Methods of assessment of iodine status in humans: a systematic review

2009
Authors
Ristić-Medić, Danijela K.
Piskackova, Zlata
Hooper, Lee

Ruprich, Jiri
Casgrain, Amelie
Ashton, Kate
Pavlović, Mirjana
Glibetić, Marija

Article (Published version)

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Background: Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies. Objective: The objective was to assess the usefulness of biomarkers of iodine status in humans by systematically reviewing intervention studies that altered iodine status. Design: We performed a structured search for iodine intervention studies on Ovid MEDLINE, EMBASE (Ovid), and the Cochrane Library. Studies were assessed for inclusion and validity, with independent duplication. A random-effects meta-analysis was performed. Results: Twenty-one intervention studies (12 randomized controlled trials, 3 controlled clinical trials, and 6 before-after studies) were included in the review. Urinary iodine (in children and adolescents and in those with low and moderate baseline iodine status), thyroglobulin (in children and adolescents but not in pregnant and lactating women), serum thyroxine (in children and adolesce...nts, adults, women, and those with moderate baseline thyroxine status but not in pregnant and lactating women), and serum thyroid-stimulating hormone (in pregnant and lactating women but not in children and adolescents or those at moderate baseline status), but not triiodothyronine, proved to be useful biomarkers of iodine status. Conclusions: Despite the high risk of bias of many of the included studies, the results suggested that urinary iodine, thyroglobin, serum thyroxine, and thyroid-stimulating hormone are useful biomarkers of iodine status, at least in some groups. High-quality controlled studies measuring relevant long-term outcomes are needed to address which biomarker is the most appropriate for assessing iodine intake in some population groups and settings. Am J Clin Nutr 2009; 89(suppl): 2052S-69S.
Source:
American Journal of Clinical Nutrition, 2009, 89, 6, 2052S-2069SPublisher:
- Oxford Univ Press, Oxford
DOI: 10.3945/ajcn.2009.27230H
ISSN: 0002-9165
PubMed: 19420096
WoS: 000266245500047
Scopus: 2-s2.0-66849131599
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Institut za medicinska istraživanjaTY - JOUR AU - Ristić-Medić, Danijela K. AU - Piskackova, Zlata AU - Hooper, Lee AU - Ruprich, Jiri AU - Casgrain, Amelie AU - Ashton, Kate AU - Pavlović, Mirjana AU - Glibetić, Marija PY - 2009 UR - http://rimi.imi.bg.ac.rs/handle/123456789/249 AB - Background: Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies. Objective: The objective was to assess the usefulness of biomarkers of iodine status in humans by systematically reviewing intervention studies that altered iodine status. Design: We performed a structured search for iodine intervention studies on Ovid MEDLINE, EMBASE (Ovid), and the Cochrane Library. Studies were assessed for inclusion and validity, with independent duplication. A random-effects meta-analysis was performed. Results: Twenty-one intervention studies (12 randomized controlled trials, 3 controlled clinical trials, and 6 before-after studies) were included in the review. Urinary iodine (in children and adolescents and in those with low and moderate baseline iodine status), thyroglobulin (in children and adolescents but not in pregnant and lactating women), serum thyroxine (in children and adolescents, adults, women, and those with moderate baseline thyroxine status but not in pregnant and lactating women), and serum thyroid-stimulating hormone (in pregnant and lactating women but not in children and adolescents or those at moderate baseline status), but not triiodothyronine, proved to be useful biomarkers of iodine status. Conclusions: Despite the high risk of bias of many of the included studies, the results suggested that urinary iodine, thyroglobin, serum thyroxine, and thyroid-stimulating hormone are useful biomarkers of iodine status, at least in some groups. High-quality controlled studies measuring relevant long-term outcomes are needed to address which biomarker is the most appropriate for assessing iodine intake in some population groups and settings. Am J Clin Nutr 2009; 89(suppl): 2052S-69S. PB - Oxford Univ Press, Oxford T2 - American Journal of Clinical Nutrition T1 - Methods of assessment of iodine status in humans: a systematic review EP - 2069S IS - 6 SP - 2052S VL - 89 DO - 10.3945/ajcn.2009.27230H ER -
@article{ author = "Ristić-Medić, Danijela K. and Piskackova, Zlata and Hooper, Lee and Ruprich, Jiri and Casgrain, Amelie and Ashton, Kate and Pavlović, Mirjana and Glibetić, Marija", year = "2009", abstract = "Background: Biomarkers of iodine status are required to study iodine deficiency disorders in different parts of the world and to evaluate the effects of fortification strategies. Objective: The objective was to assess the usefulness of biomarkers of iodine status in humans by systematically reviewing intervention studies that altered iodine status. Design: We performed a structured search for iodine intervention studies on Ovid MEDLINE, EMBASE (Ovid), and the Cochrane Library. Studies were assessed for inclusion and validity, with independent duplication. A random-effects meta-analysis was performed. Results: Twenty-one intervention studies (12 randomized controlled trials, 3 controlled clinical trials, and 6 before-after studies) were included in the review. Urinary iodine (in children and adolescents and in those with low and moderate baseline iodine status), thyroglobulin (in children and adolescents but not in pregnant and lactating women), serum thyroxine (in children and adolescents, adults, women, and those with moderate baseline thyroxine status but not in pregnant and lactating women), and serum thyroid-stimulating hormone (in pregnant and lactating women but not in children and adolescents or those at moderate baseline status), but not triiodothyronine, proved to be useful biomarkers of iodine status. Conclusions: Despite the high risk of bias of many of the included studies, the results suggested that urinary iodine, thyroglobin, serum thyroxine, and thyroid-stimulating hormone are useful biomarkers of iodine status, at least in some groups. High-quality controlled studies measuring relevant long-term outcomes are needed to address which biomarker is the most appropriate for assessing iodine intake in some population groups and settings. Am J Clin Nutr 2009; 89(suppl): 2052S-69S.", publisher = "Oxford Univ Press, Oxford", journal = "American Journal of Clinical Nutrition", title = "Methods of assessment of iodine status in humans: a systematic review", pages = "2069S-2052S", number = "6", volume = "89", doi = "10.3945/ajcn.2009.27230H" }
Ristić-Medić, D. K., Piskackova, Z., Hooper, L., Ruprich, J., Casgrain, A., Ashton, K., Pavlović, M.,& Glibetić, M.. (2009). Methods of assessment of iodine status in humans: a systematic review. in American Journal of Clinical Nutrition Oxford Univ Press, Oxford., 89(6), 2052S-2069S. https://doi.org/10.3945/ajcn.2009.27230H
Ristić-Medić DK, Piskackova Z, Hooper L, Ruprich J, Casgrain A, Ashton K, Pavlović M, Glibetić M. Methods of assessment of iodine status in humans: a systematic review. in American Journal of Clinical Nutrition. 2009;89(6):2052S-2069S. doi:10.3945/ajcn.2009.27230H .
Ristić-Medić, Danijela K., Piskackova, Zlata, Hooper, Lee, Ruprich, Jiri, Casgrain, Amelie, Ashton, Kate, Pavlović, Mirjana, Glibetić, Marija, "Methods of assessment of iodine status in humans: a systematic review" in American Journal of Clinical Nutrition, 89, no. 6 (2009):2052S-2069S, https://doi.org/10.3945/ajcn.2009.27230H . .