The effects of interleukin (IL)-17 on nitric oxide (NO) synthase (NOS) expression, as well as the participation of mitogen-activated protein kinases (MAPKs) in IL-17-mediated effects were examined in murine bone marrow cells. The results demonstrated the ability of IL-17 to upregulate the expression of mRNA for both inducible NOS and constitutive, endothelial NOS isoforms, as well as to enhance the phosphorylation of p38 MAPK. Moreover, both the NOS-inducing effect of IL-17 and the in vitro IL-17-mediated inhibition colony forming unit-erythroid (CFU-E) growth were dependent on p38 MAPK activity. The data demonstrating that the in vivo reducing effect of IL-17 on bone marrow CFU-E was prevented by co-treatment with the NOS inhibitor Nw-nitro-l-arginine methyl ester hydrochloride (L-NAME), implied that this effect is mediated through NOS activation. Besides revealing a link between the IL-17, NO, and haematopoiesis, data presented gave an insight into the mechanisms by which IL-17 exert...s its modulatory effects on bone marrow cells.
TY - JOUR
AU - Krstić, Aleksandra
AU - Ilić, Vesna
AU - Mojsilović, Slavko
AU - Jovčić, Gordana
AU - Milenković, Pavle B.
AU - Bugarski, Diana
PY - 2009
UR - http://rimi.imi.bg.ac.rs/handle/123456789/242
AB - The effects of interleukin (IL)-17 on nitric oxide (NO) synthase (NOS) expression, as well as the participation of mitogen-activated protein kinases (MAPKs) in IL-17-mediated effects were examined in murine bone marrow cells. The results demonstrated the ability of IL-17 to upregulate the expression of mRNA for both inducible NOS and constitutive, endothelial NOS isoforms, as well as to enhance the phosphorylation of p38 MAPK. Moreover, both the NOS-inducing effect of IL-17 and the in vitro IL-17-mediated inhibition colony forming unit-erythroid (CFU-E) growth were dependent on p38 MAPK activity. The data demonstrating that the in vivo reducing effect of IL-17 on bone marrow CFU-E was prevented by co-treatment with the NOS inhibitor Nw-nitro-l-arginine methyl ester hydrochloride (L-NAME), implied that this effect is mediated through NOS activation. Besides revealing a link between the IL-17, NO, and haematopoiesis, data presented gave an insight into the mechanisms by which IL-17 exerts its modulatory effects on bone marrow cells.
PB - Taylor & Francis Ltd, Abingdon
T2 - Growth Factors
T1 - p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells
EP - 90
IS - 2
SP - 79
VL - 27
DO - 10.1080/08977190902757153
ER -
@article{
author = "Krstić, Aleksandra and Ilić, Vesna and Mojsilović, Slavko and Jovčić, Gordana and Milenković, Pavle B. and Bugarski, Diana",
year = "2009",
abstract = "The effects of interleukin (IL)-17 on nitric oxide (NO) synthase (NOS) expression, as well as the participation of mitogen-activated protein kinases (MAPKs) in IL-17-mediated effects were examined in murine bone marrow cells. The results demonstrated the ability of IL-17 to upregulate the expression of mRNA for both inducible NOS and constitutive, endothelial NOS isoforms, as well as to enhance the phosphorylation of p38 MAPK. Moreover, both the NOS-inducing effect of IL-17 and the in vitro IL-17-mediated inhibition colony forming unit-erythroid (CFU-E) growth were dependent on p38 MAPK activity. The data demonstrating that the in vivo reducing effect of IL-17 on bone marrow CFU-E was prevented by co-treatment with the NOS inhibitor Nw-nitro-l-arginine methyl ester hydrochloride (L-NAME), implied that this effect is mediated through NOS activation. Besides revealing a link between the IL-17, NO, and haematopoiesis, data presented gave an insight into the mechanisms by which IL-17 exerts its modulatory effects on bone marrow cells.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Growth Factors",
title = "p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells",
pages = "90-79",
number = "2",
volume = "27",
doi = "10.1080/08977190902757153"
}
Krstić, A., Ilić, V., Mojsilović, S., Jovčić, G., Milenković, P. B.,& Bugarski, D.. (2009). p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells. in Growth Factors
Taylor & Francis Ltd, Abingdon., 27(2), 79-90.
https://doi.org/10.1080/08977190902757153
Krstić A, Ilić V, Mojsilović S, Jovčić G, Milenković PB, Bugarski D. p38 MAPK signaling mediates IL-17-induced nitric oxide synthase expression in bone marrow cells. in Growth Factors. 2009;27(2):79-90.
doi:10.1080/08977190902757153 .
