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Blockade of Nitric Oxide Synthesis Modulates Rat Immunoglobulin A
dc.creator | Budeč, Mirela | |
dc.creator | Marković, Dragana | |
dc.creator | Đikić, Dragoslava | |
dc.creator | Mitrović, Olivera | |
dc.creator | Drndarević, Neda | |
dc.creator | Koko, Vesna | |
dc.creator | Todorović, Vera | |
dc.date.accessioned | 2021-04-20T12:16:04Z | |
dc.date.available | 2021-04-20T12:16:04Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1021-7401 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/219 | |
dc.description.abstract | Objective: Nitric oxide (NO) is known as a regulator of inflammation and immunity. The purpose of this study was to investigate the influence of this signal molecule on the rat immunoglobulin A (IgA) system using N omega-nitro-L-arginine-methyl ester (L-NAME), which inhibits the activity of all isoforms of NO synthase. Methods: The experiments were performed on adult female Wistar rats showing diestrus day 1 that were treated with L-NAME (30 or 50 mg/kg, s.c.). Untreated and saline-injected animals were used as controls. The rats were sacrificed 3 h following L-NAME or saline administration. The concentration of IgA in serum and intestinal extracts was determined by a sandwich enzyme-linked immunosorbent assay. The number of IgA-expressing cells per area unit of Peyer's patches and the intestinal lamina propria was evaluated using stereological analysis. Results: The results showed that L-NAME decreased the level of IgA in serum and elevated its concentration in intestinal extracts. Additionally, the increased number of IgA+ cells was found in the intestinal lamina propria in both experimental groups. Conclusion: Obtained findings imply that endogenous NO may modulate the IgA system in the rat. Copyright (C) 2009 S. Karger AG, Basel | en |
dc.publisher | Karger, Basel | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/145064/RS// | |
dc.rights | restrictedAccess | |
dc.source | Neuroimmunomodulation | |
dc.subject | N omega-nitro-L-arginine-methyl ester | en |
dc.subject | Immunoglobulin A | en |
dc.subject | Rat small intestine | en |
dc.title | Blockade of Nitric Oxide Synthesis Modulates Rat Immunoglobulin A | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 161 | |
dc.citation.issue | 3 | |
dc.citation.other | 16(3): 155-161 | |
dc.citation.rank | M23 | |
dc.citation.spage | 155 | |
dc.citation.volume | 16 | |
dc.identifier.doi | 10.1159/000204228 | |
dc.identifier.pmid | 19246937 | |
dc.identifier.scopus | 2-s2.0-60749108628 | |
dc.identifier.wos | 000264025100002 | |
dc.type.version | publishedVersion |