The prognosis of CMV retinitis among patients with AIDS in Serbia
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2008
Authors
Dujić, A.Jevtović, Đorđe

Salemović, Dubravka
Ranin, Jovan
Brmbolić, Branko
Đurković-Đaković, Olgica

Article (Published version)

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Background: Cytomegalovirus (CMV) end-organ diseases, including CMV retinitis, are major opportunistic events in terminal AIDS patients. Methods: A retrospective study of 30 AIDS patients with CMV retinitis treated between 1997 and 2007 in Serbia was conducted to examine the prognosis and factors associated with survival. Results: Eighteen (60%) patients survived the mean follow-up period of 46.4 +/- 36 months. Patients' sex, mode of HIV transmission or previous AIDS diagnosis did not affect survival. Bilateral CMV retinitis predicted dissemination of CMV disease and poor prognosis (OR 7.8, 95% Cl 1.3-47.0, P = 0.012), but was not associated with blindness (P = 0.33). Among patients treated with HAART and CMV therapy the probability of surviving 10 years was 70%, while in those on CMV therapy alone, the median survival was 10 months (log rank P = 0.00). However, HAART itself was not sufficient to prevent blindness and the major predictor of blindness was a baseline CD4 cell count of le...ss than 50/mu L (OR 6.8, 95% Cl 1.1-41.8, P = 0.03). After CMV disease, most patients suffered other opportunistic events regardless of HAART introduction. Conclusion: Even in the HAART era patients with advanced immunodeficiency and CMV retinitis may not escape from the high risk mortality group, while survivors commonly lose sight.
Keywords:
AIDS / CMV retinitis / survivalSource:
Biomedicine & Pharmacotherapy, 2008, 62, 7, 443-447Publisher:
- Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux
Funding / projects:
DOI: 10.1016/j.biopha.2007.12.011
ISSN: 0753-3322
PubMed: 18243635
WoS: 000259357500031
Scopus: 2-s2.0-48349118363
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Institut za medicinska istraživanjaTY - JOUR AU - Dujić, A. AU - Jevtović, Đorđe AU - Salemović, Dubravka AU - Ranin, Jovan AU - Brmbolić, Branko AU - Đurković-Đaković, Olgica PY - 2008 UR - http://rimi.imi.bg.ac.rs/handle/123456789/211 AB - Background: Cytomegalovirus (CMV) end-organ diseases, including CMV retinitis, are major opportunistic events in terminal AIDS patients. Methods: A retrospective study of 30 AIDS patients with CMV retinitis treated between 1997 and 2007 in Serbia was conducted to examine the prognosis and factors associated with survival. Results: Eighteen (60%) patients survived the mean follow-up period of 46.4 +/- 36 months. Patients' sex, mode of HIV transmission or previous AIDS diagnosis did not affect survival. Bilateral CMV retinitis predicted dissemination of CMV disease and poor prognosis (OR 7.8, 95% Cl 1.3-47.0, P = 0.012), but was not associated with blindness (P = 0.33). Among patients treated with HAART and CMV therapy the probability of surviving 10 years was 70%, while in those on CMV therapy alone, the median survival was 10 months (log rank P = 0.00). However, HAART itself was not sufficient to prevent blindness and the major predictor of blindness was a baseline CD4 cell count of less than 50/mu L (OR 6.8, 95% Cl 1.1-41.8, P = 0.03). After CMV disease, most patients suffered other opportunistic events regardless of HAART introduction. Conclusion: Even in the HAART era patients with advanced immunodeficiency and CMV retinitis may not escape from the high risk mortality group, while survivors commonly lose sight. PB - Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux T2 - Biomedicine & Pharmacotherapy T1 - The prognosis of CMV retinitis among patients with AIDS in Serbia EP - 447 IS - 7 SP - 443 VL - 62 DO - 10.1016/j.biopha.2007.12.011 UR - conv_2004 ER -
@article{ author = "Dujić, A. and Jevtović, Đorđe and Salemović, Dubravka and Ranin, Jovan and Brmbolić, Branko and Đurković-Đaković, Olgica", year = "2008", abstract = "Background: Cytomegalovirus (CMV) end-organ diseases, including CMV retinitis, are major opportunistic events in terminal AIDS patients. Methods: A retrospective study of 30 AIDS patients with CMV retinitis treated between 1997 and 2007 in Serbia was conducted to examine the prognosis and factors associated with survival. Results: Eighteen (60%) patients survived the mean follow-up period of 46.4 +/- 36 months. Patients' sex, mode of HIV transmission or previous AIDS diagnosis did not affect survival. Bilateral CMV retinitis predicted dissemination of CMV disease and poor prognosis (OR 7.8, 95% Cl 1.3-47.0, P = 0.012), but was not associated with blindness (P = 0.33). Among patients treated with HAART and CMV therapy the probability of surviving 10 years was 70%, while in those on CMV therapy alone, the median survival was 10 months (log rank P = 0.00). However, HAART itself was not sufficient to prevent blindness and the major predictor of blindness was a baseline CD4 cell count of less than 50/mu L (OR 6.8, 95% Cl 1.1-41.8, P = 0.03). After CMV disease, most patients suffered other opportunistic events regardless of HAART introduction. Conclusion: Even in the HAART era patients with advanced immunodeficiency and CMV retinitis may not escape from the high risk mortality group, while survivors commonly lose sight.", publisher = "Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux", journal = "Biomedicine & Pharmacotherapy", title = "The prognosis of CMV retinitis among patients with AIDS in Serbia", pages = "447-443", number = "7", volume = "62", doi = "10.1016/j.biopha.2007.12.011", url = "conv_2004" }
Dujić, A., Jevtović, Đ., Salemović, D., Ranin, J., Brmbolić, B.,& Đurković-Đaković, O.. (2008). The prognosis of CMV retinitis among patients with AIDS in Serbia. in Biomedicine & Pharmacotherapy Elsevier France-Editions Scientifiques Medicales Elsevier, Issy-Les-Moulineaux., 62(7), 443-447. https://doi.org/10.1016/j.biopha.2007.12.011 conv_2004
Dujić A, Jevtović Đ, Salemović D, Ranin J, Brmbolić B, Đurković-Đaković O. The prognosis of CMV retinitis among patients with AIDS in Serbia. in Biomedicine & Pharmacotherapy. 2008;62(7):443-447. doi:10.1016/j.biopha.2007.12.011 conv_2004 .
Dujić, A., Jevtović, Đorđe, Salemović, Dubravka, Ranin, Jovan, Brmbolić, Branko, Đurković-Đaković, Olgica, "The prognosis of CMV retinitis among patients with AIDS in Serbia" in Biomedicine & Pharmacotherapy, 62, no. 7 (2008):443-447, https://doi.org/10.1016/j.biopha.2007.12.011 ., conv_2004 .