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dc.creatorMiloradović, Zoran
dc.creatorJovović, Đurđica
dc.creatorMihailović-Stanojević, Nevena
dc.creatorGrujić-Milanović, Jelica
dc.creatorMilanović, Slađan
dc.date.accessioned2021-04-20T12:15:21Z
dc.date.available2021-04-20T12:15:21Z
dc.date.issued2008
dc.identifier.issn0008-4212
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/208
dc.description.abstractRecently, it has been reported that losartan, an angiotensin II receptor (ATR) antagonist, depresses the angiotensin II-induced production of superoxide radicals. Also, in spontaneously hypertensive rats (SHR) endothelial dysfunction is associated with decreased nitric oxide (NO) synthesis. In this study, we examined the effects of long-term ATR blockade and L-arginine supplementation on the haemodynamic parameters, glomerular filtration, and oxidative status in SHR. Adult male SHR were treated with losartan (10 mg/kg) and with the NO donor L-arginine (2 g/kg) for 4 weeks. The animals were divided into the following experimental groups: control (n = 7), L-arginine (n = 7), losartan (n = 7), and L-arginine + losartan (n = 7). Mean arterial pressure (MAP), regional blood flow, urea clearance, and activity of superoxide dismutase (SOD) were measured at the end of treatment. MAP was significantly reduced in the losartan group compared with the control group (133.3 +/- 7.3 vs. 161.5 +/- 14.5 mm Hg). Aortic blood flow was significantly higher and aortic vascular resistance was significantly lower in all treated groups than in the control. Urea clearance rose significantly in the L-arginine + losartan group compared with control (393.27 +/- 37.58 vs. 218.68 +/- 42.03 mu L center dot min(-1)center dot 100 g(-1)), as did the activity of SOD (1668.97 +/- 244.57 vs. 1083.18 +/- 169.96 U/g Hb). Our results suggest that the antihypertensive effect of losartan and L-arginine in SHR is not primarily mediated by increased SOD activity. Also, combined treatment with ATR blockade and L-arginine supplementation has a beneficial effect on renal function that is, at least in part, mediated by increased SOD activity in SHR.en
dc.publisherCanadian Science Publishing, Ottawa
dc.rightsrestrictedAccess
dc.sourceCanadian Journal of Physiology & Pharmacology
dc.subjectsHRen
dc.subjectlosartanen
dc.subjectL-arginineen
dc.subjectSOD activityen
dc.subjecthaemodynamicsen
dc.subjectglomerular filtrationen
dc.titleEffects of long-term losartan and L-arginine treatment on haemodynamics, glomerular filtration, and SOD activity in spontaneously hypertensive ratsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage214
dc.citation.issue4
dc.citation.other86(4): 210-214
dc.citation.rankM23
dc.citation.spage210
dc.citation.volume86
dc.identifier.doi10.1139/Y08-022
dc.identifier.pmid18418431
dc.identifier.scopus2-s2.0-42149133085
dc.identifier.wos000255517000011
dc.type.versionpublishedVersion


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