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dc.creatorIlić, Vesna
dc.creatorMilošević-Jovčić, Nadežda
dc.creatorPetrović, Sonja
dc.creatorMarković, Dragana
dc.creatorBila, Jelena
dc.creatorBošković, Darinka
dc.creatorStefanović, Gordana
dc.creatorMarković, Olivera
dc.creatorGlibetić, Marija
dc.date.accessioned2021-04-20T12:12:11Z
dc.date.available2021-04-20T12:12:11Z
dc.date.issued2007
dc.identifier.issn0939-5555
dc.identifier.urihttp://rimi.imi.bg.ac.rs/handle/123456789/161
dc.description.abstractCirculating post-switch B cells have been proposed as proliferative and disseminating progenitors in multiple myeloma. It is unclear whether the class-switched antigen receptor expressed at the surface of these cells plays a role in their expansion. In this work, the signaling status of IgG B cell receptor (BCR) isolated from the lysates of peripheral blood lymphocytes of 32 patients with IgG multiple myeloma, at the time of diagnosis, was investigated by examining whether phosphorylation of BCR Ig alpha and Ig beta signal transducer factors (co-receptors) or other signaling molecules was abnormal in these cells when compared with healthy controls. In IgG BCR of normal controls, weak phosphorylation of 56 and 61 kDa Src kinase-related proteins and unphosphorylated co-receptors were found. In myeloma, p56 and p61 kDa proteins, co-receptors, and other IgG BCR-associated proteins from the signal cascade were phosphorylated. Myeloma patients can be classified into subgroups by IgG BCR phosphorylation profiles which characteristically coordinated with the level of IgG paraprotein in serum and the stage of disease. There was a correlative trend between the extent of phosphorylation reduction and advanced stage of disease. Reduced phosphorylation was more pronounced with advanced stages of multiple myeloma.en
dc.publisherSpringer, New York
dc.rightsrestrictedAccess
dc.sourceAnnals of Hematology
dc.subjectIgG B-cell receptoren
dc.subjecttyrosine phosphorylationen
dc.subjectmultiple myelomaen
dc.titleSignaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myelomaen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage912
dc.citation.issue12
dc.citation.other86(12): 905-912
dc.citation.rankM22
dc.citation.spage905
dc.citation.volume86
dc.identifier.doi10.1007/s00277-007-0352-0
dc.identifier.pmid17701175
dc.identifier.scopus2-s2.0-40949095753
dc.identifier.wos000250372600007
dc.type.versionpublishedVersion


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