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Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma

Authorized Users Only
2007
Authors
Ilić, Vesna
Milošević-Jovčić, Nadežda
Petrović, Sonja
Marković, Dragana
Bila, Jelena
Bošković, Darinka
Stefanović, Gordana
Marković, Olivera
Glibetić, Marija
Article (Published version)
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Abstract
Circulating post-switch B cells have been proposed as proliferative and disseminating progenitors in multiple myeloma. It is unclear whether the class-switched antigen receptor expressed at the surface of these cells plays a role in their expansion. In this work, the signaling status of IgG B cell receptor (BCR) isolated from the lysates of peripheral blood lymphocytes of 32 patients with IgG multiple myeloma, at the time of diagnosis, was investigated by examining whether phosphorylation of BCR Ig alpha and Ig beta signal transducer factors (co-receptors) or other signaling molecules was abnormal in these cells when compared with healthy controls. In IgG BCR of normal controls, weak phosphorylation of 56 and 61 kDa Src kinase-related proteins and unphosphorylated co-receptors were found. In myeloma, p56 and p61 kDa proteins, co-receptors, and other IgG BCR-associated proteins from the signal cascade were phosphorylated. Myeloma patients can be classified into subgroups by IgG BCR phos...phorylation profiles which characteristically coordinated with the level of IgG paraprotein in serum and the stage of disease. There was a correlative trend between the extent of phosphorylation reduction and advanced stage of disease. Reduced phosphorylation was more pronounced with advanced stages of multiple myeloma.

Keywords:
IgG B-cell receptor / tyrosine phosphorylation / multiple myeloma
Source:
Annals of Hematology, 2007, 86, 12, 905-912
Publisher:
  • Springer, New York

DOI: 10.1007/s00277-007-0352-0

ISSN: 0939-5555

PubMed: 17701175

WoS: 000250372600007

Scopus: 2-s2.0-40949095753
[ Google Scholar ]
2
1
URI
http://rimi.imi.bg.ac.rs/handle/123456789/161
Collections
  • Radovi istraživača / Researchers' publications
Institution/Community
Institut za medicinska istraživanja
TY  - JOUR
AU  - Ilić, Vesna
AU  - Milošević-Jovčić, Nadežda
AU  - Petrović, Sonja
AU  - Marković, Dragana
AU  - Bila, Jelena
AU  - Bošković, Darinka
AU  - Stefanović, Gordana
AU  - Marković, Olivera
AU  - Glibetić, Marija
PY  - 2007
UR  - http://rimi.imi.bg.ac.rs/handle/123456789/161
AB  - Circulating post-switch B cells have been proposed as proliferative and disseminating progenitors in multiple myeloma. It is unclear whether the class-switched antigen receptor expressed at the surface of these cells plays a role in their expansion. In this work, the signaling status of IgG B cell receptor (BCR) isolated from the lysates of peripheral blood lymphocytes of 32 patients with IgG multiple myeloma, at the time of diagnosis, was investigated by examining whether phosphorylation of BCR Ig alpha and Ig beta signal transducer factors (co-receptors) or other signaling molecules was abnormal in these cells when compared with healthy controls. In IgG BCR of normal controls, weak phosphorylation of 56 and 61 kDa Src kinase-related proteins and unphosphorylated co-receptors were found. In myeloma, p56 and p61 kDa proteins, co-receptors, and other IgG BCR-associated proteins from the signal cascade were phosphorylated. Myeloma patients can be classified into subgroups by IgG BCR phosphorylation profiles which characteristically coordinated with the level of IgG paraprotein in serum and the stage of disease. There was a correlative trend between the extent of phosphorylation reduction and advanced stage of disease. Reduced phosphorylation was more pronounced with advanced stages of multiple myeloma.
PB  - Springer, New York
T2  - Annals of Hematology
T1  - Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma
EP  - 912
IS  - 12
SP  - 905
VL  - 86
DO  - 10.1007/s00277-007-0352-0
ER  - 
@article{
author = "Ilić, Vesna and Milošević-Jovčić, Nadežda and Petrović, Sonja and Marković, Dragana and Bila, Jelena and Bošković, Darinka and Stefanović, Gordana and Marković, Olivera and Glibetić, Marija",
year = "2007",
abstract = "Circulating post-switch B cells have been proposed as proliferative and disseminating progenitors in multiple myeloma. It is unclear whether the class-switched antigen receptor expressed at the surface of these cells plays a role in their expansion. In this work, the signaling status of IgG B cell receptor (BCR) isolated from the lysates of peripheral blood lymphocytes of 32 patients with IgG multiple myeloma, at the time of diagnosis, was investigated by examining whether phosphorylation of BCR Ig alpha and Ig beta signal transducer factors (co-receptors) or other signaling molecules was abnormal in these cells when compared with healthy controls. In IgG BCR of normal controls, weak phosphorylation of 56 and 61 kDa Src kinase-related proteins and unphosphorylated co-receptors were found. In myeloma, p56 and p61 kDa proteins, co-receptors, and other IgG BCR-associated proteins from the signal cascade were phosphorylated. Myeloma patients can be classified into subgroups by IgG BCR phosphorylation profiles which characteristically coordinated with the level of IgG paraprotein in serum and the stage of disease. There was a correlative trend between the extent of phosphorylation reduction and advanced stage of disease. Reduced phosphorylation was more pronounced with advanced stages of multiple myeloma.",
publisher = "Springer, New York",
journal = "Annals of Hematology",
title = "Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma",
pages = "912-905",
number = "12",
volume = "86",
doi = "10.1007/s00277-007-0352-0"
}
Ilić, V., Milošević-Jovčić, N., Petrović, S., Marković, D., Bila, J., Bošković, D., Stefanović, G., Marković, O.,& Glibetić, M.. (2007). Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma. in Annals of Hematology
Springer, New York., 86(12), 905-912.
https://doi.org/10.1007/s00277-007-0352-0
conv_1880
Ilić V, Milošević-Jovčić N, Petrović S, Marković D, Bila J, Bošković D, Stefanović G, Marković O, Glibetić M. Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma. in Annals of Hematology. 2007;86(12):905-912.
doi:10.1007/s00277-007-0352-0
conv_1880 .
Ilić, Vesna, Milošević-Jovčić, Nadežda, Petrović, Sonja, Marković, Dragana, Bila, Jelena, Bošković, Darinka, Stefanović, Gordana, Marković, Olivera, Glibetić, Marija, "Signaling status of IgG B cell receptor (IgG BCR) is indicative for an activated state of circulating B cells in multiple myeloma" in Annals of Hematology, 86, no. 12 (2007):905-912,
https://doi.org/10.1007/s00277-007-0352-0 .,
conv_1880 .

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