Liver phospholipid fatty acid composition in response to chronic high-fat diets
Само за регистроване кориснике
2024
Аутори
Popović, Tamara![](/themes/MirageRIMI/images/orcid.png)
Nenadović, Aleksandra
![](/themes/MirageRIMI/images/orcid.png)
Stanković, Anica
Debeljak Martačić, Jasmina
![](/themes/MirageRIMI/images/orcid.png)
Ranković, Slavica
![](/themes/MirageRIMI/images/orcid.png)
Kovačević, Sanjin
![](/themes/MirageRIMI/images/orcid.png)
Nešović Ostojić, Jelena
![](/themes/MirageRIMI/images/orcid.png)
Ilić, Anđelija
![](/themes/MirageRIMI/images/orcid.png)
Milašin, Jelena
![](/themes/MirageRIMI/images/orcid.png)
De Luka, Silvio
![](/themes/MirageRIMI/images/orcid.png)
Trbovich, Alexander M.
Чланак у часопису (Објављена верзија)
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Метаподаци
Приказ свих података о документуАпстракт
Liver phospholipid fatty acid composition depends on the dietary lipid intake and the efficiency of hepatic enzymatic activity. Our study aimed to simultaneously investigate the liver phospholipid fatty acid composition in response to chronic linseed, palm, or sunflower oil diets. We used adult female C57/BL6 mice and randomly divided them into control and three groups treated with 25 % dietary oils. Prior to treatment, we analyzed the fatty acid profiles in dietary oils and hepatocytes and, after 100 days, the fatty acid composition in the liver using gas-liquid chromatography. Linseed oil treatment elevated alpha-linolenic, eicosapentaenoic, and docosapentaenoic acids and reduced arachidonic and docosatetraenoic acids, consequently lowering the n-6/n-3 ratio. Palm oil treatment increased linoleic acid and decreased docosahexaenoic acid, contributing to an elevated n-6/n-3 ratio. Sunflower oil treatment elevated total monounsaturated fatty acids by increasing palmitoleic, oleic, and v...accenic acids. The estimated activity of Δ9 desaturase was significantly elevated in the sunflower oil group, while Δ5 desaturase was the highest, and Δ6 desaturase was the lowest after the linseed oil diet. Our findings demonstrate that chronic consumption of linseed, palm, or sunflower oil alters the distribution of liver phospholipid fatty acids differently. Sunflower oil diet elevated total monounsaturated fatty acids, proposing potential benefits for liver tissue health. Considering these outcomes, a substantial recommendation emerges to elevate linseed oil intake, recognized as the principal ALA source, thereby aiding in reducing the n-6/n-3 ratio. Moreover, modifying dietary habits to incorporate specific vegetable oils in daily consumption could substantially enhance overall health.
Кључне речи:
Chronic high-fat diet / Liver / Linseed oil / Palm oil / Phospholipid fatty acids / Sunflower oilИзвор:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2024, 1869, 7, 159526-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Popović, Tamara AU - Nenadović, Aleksandra AU - Stanković, Anica AU - Debeljak Martačić, Jasmina AU - Ranković, Slavica AU - Kovačević, Sanjin AU - Nešović Ostojić, Jelena AU - Ilić, Anđelija AU - Milašin, Jelena AU - De Luka, Silvio AU - Trbovich, Alexander M. PY - 2024 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1502 AB - Liver phospholipid fatty acid composition depends on the dietary lipid intake and the efficiency of hepatic enzymatic activity. Our study aimed to simultaneously investigate the liver phospholipid fatty acid composition in response to chronic linseed, palm, or sunflower oil diets. We used adult female C57/BL6 mice and randomly divided them into control and three groups treated with 25 % dietary oils. Prior to treatment, we analyzed the fatty acid profiles in dietary oils and hepatocytes and, after 100 days, the fatty acid composition in the liver using gas-liquid chromatography. Linseed oil treatment elevated alpha-linolenic, eicosapentaenoic, and docosapentaenoic acids and reduced arachidonic and docosatetraenoic acids, consequently lowering the n-6/n-3 ratio. Palm oil treatment increased linoleic acid and decreased docosahexaenoic acid, contributing to an elevated n-6/n-3 ratio. Sunflower oil treatment elevated total monounsaturated fatty acids by increasing palmitoleic, oleic, and vaccenic acids. The estimated activity of Δ9 desaturase was significantly elevated in the sunflower oil group, while Δ5 desaturase was the highest, and Δ6 desaturase was the lowest after the linseed oil diet. Our findings demonstrate that chronic consumption of linseed, palm, or sunflower oil alters the distribution of liver phospholipid fatty acids differently. Sunflower oil diet elevated total monounsaturated fatty acids, proposing potential benefits for liver tissue health. Considering these outcomes, a substantial recommendation emerges to elevate linseed oil intake, recognized as the principal ALA source, thereby aiding in reducing the n-6/n-3 ratio. Moreover, modifying dietary habits to incorporate specific vegetable oils in daily consumption could substantially enhance overall health. PB - Elsevier T2 - Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids T1 - Liver phospholipid fatty acid composition in response to chronic high-fat diets IS - 7 SP - 159526 VL - 1869 DO - 10.1016/j.bbalip.2024.159526 ER -
@article{ author = "Popović, Tamara and Nenadović, Aleksandra and Stanković, Anica and Debeljak Martačić, Jasmina and Ranković, Slavica and Kovačević, Sanjin and Nešović Ostojić, Jelena and Ilić, Anđelija and Milašin, Jelena and De Luka, Silvio and Trbovich, Alexander M.", year = "2024", abstract = "Liver phospholipid fatty acid composition depends on the dietary lipid intake and the efficiency of hepatic enzymatic activity. Our study aimed to simultaneously investigate the liver phospholipid fatty acid composition in response to chronic linseed, palm, or sunflower oil diets. We used adult female C57/BL6 mice and randomly divided them into control and three groups treated with 25 % dietary oils. Prior to treatment, we analyzed the fatty acid profiles in dietary oils and hepatocytes and, after 100 days, the fatty acid composition in the liver using gas-liquid chromatography. Linseed oil treatment elevated alpha-linolenic, eicosapentaenoic, and docosapentaenoic acids and reduced arachidonic and docosatetraenoic acids, consequently lowering the n-6/n-3 ratio. Palm oil treatment increased linoleic acid and decreased docosahexaenoic acid, contributing to an elevated n-6/n-3 ratio. Sunflower oil treatment elevated total monounsaturated fatty acids by increasing palmitoleic, oleic, and vaccenic acids. The estimated activity of Δ9 desaturase was significantly elevated in the sunflower oil group, while Δ5 desaturase was the highest, and Δ6 desaturase was the lowest after the linseed oil diet. Our findings demonstrate that chronic consumption of linseed, palm, or sunflower oil alters the distribution of liver phospholipid fatty acids differently. Sunflower oil diet elevated total monounsaturated fatty acids, proposing potential benefits for liver tissue health. Considering these outcomes, a substantial recommendation emerges to elevate linseed oil intake, recognized as the principal ALA source, thereby aiding in reducing the n-6/n-3 ratio. Moreover, modifying dietary habits to incorporate specific vegetable oils in daily consumption could substantially enhance overall health.", publisher = "Elsevier", journal = "Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids", title = "Liver phospholipid fatty acid composition in response to chronic high-fat diets", number = "7", pages = "159526", volume = "1869", doi = "10.1016/j.bbalip.2024.159526" }
Popović, T., Nenadović, A., Stanković, A., Debeljak Martačić, J., Ranković, S., Kovačević, S., Nešović Ostojić, J., Ilić, A., Milašin, J., De Luka, S.,& Trbovich, A. M.. (2024). Liver phospholipid fatty acid composition in response to chronic high-fat diets. in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Elsevier., 1869(7), 159526. https://doi.org/10.1016/j.bbalip.2024.159526
Popović T, Nenadović A, Stanković A, Debeljak Martačić J, Ranković S, Kovačević S, Nešović Ostojić J, Ilić A, Milašin J, De Luka S, Trbovich AM. Liver phospholipid fatty acid composition in response to chronic high-fat diets. in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2024;1869(7):159526. doi:10.1016/j.bbalip.2024.159526 .
Popović, Tamara, Nenadović, Aleksandra, Stanković, Anica, Debeljak Martačić, Jasmina, Ranković, Slavica, Kovačević, Sanjin, Nešović Ostojić, Jelena, Ilić, Anđelija, Milašin, Jelena, De Luka, Silvio, Trbovich, Alexander M., "Liver phospholipid fatty acid composition in response to chronic high-fat diets" in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1869, no. 7 (2024):159526, https://doi.org/10.1016/j.bbalip.2024.159526 . .