Quantitative profiling and baseline intervals of trace elements in healthy lung tissues
Само за регистроване кориснике
2024
Аутори
Stojsavljević, AleksandarMarković, Katarina
Lukač, Aleksandar
Ristanović, Aleksandar
Marić, Nebojša
Marković, Stefan
Šarac, Ivana
Ščančar, Janez
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Background : Human lung tissue, as an interface with the environment, is susceptible to various environmental pollutants, including trace metals. However, quantitative data on trace metals in human lung tissues remain poorly described. Methods: This study aimed to characterize the elemental composition of histologically healthy, unaffected parts of human lung tissues, associated with non-infective, non-infiltrative, and non-malignant diseases (n = 60) for essential (Cr, Mn, Fe, Co, Cu, Zn, and Se) and toxic trace elements (Sr, Ni, As, Cd, and Pb). Additionally, we investigated the influence of personal factors (sex, age, and smoking habits) on the examined trace element profiles, as well as between the trace elements correlations in the healthy human lungs. Results : Among the analyzed trace elements, Fe was the most prevalent, while As was the least prevalent in healthy lung tissues. Stratifying by age revealed significantly higher Cr and Co (less Sr, Ni, and Pb) and lower Se levels i...n older individuals (above 65 years) compared to their younger counterparts. Sex-based differences were also notable, with Cu and Co 1.2- and 2.3-fold higher levels in females than in males. Exploring the impact of smoking habits revealed a striking 10-fold increase in Cd levels in the lung tissues of smokers compared to non-smokers. Correlation analyses showed significant positive associations between concentrations of certain toxic and essential trace elements in healthy lung tissues. Conclusions: This study could contribute to the establishment of baseline intervals for essential and toxic trace elements, valuable for toxicological and clinical assessment, in healthy, unaffected human lungs, and indicates the influence of sex, age, and smoking. However, further larger-scale studies are needed to make more stable conclusions.
Кључне речи:
Human healthy lung tissue / Trace elements concentrations / Smoking / Age / SexИзвор:
Journal of Trace Elements in Medicine and Biology, 2024, 84, 127440-Издавач:
- Elsevier
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200288 (Иновациони центар Хемијског факултета у Београду доо) (RS-MESTD-inst-2020-200288)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
- Slovenian Research and Innovation Agency (ARIS), Program group P1–0143
- Junior Researcher Grant for Katarina Markovic (52052)
DOI: 10.1016/j.jtemb.2024.127440
ISSN: 0946-672X
PubMed: 38522290
WoS: 001219242600001
Scopus: 2-s2.0-85188785284
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Stojsavljević, Aleksandar AU - Marković, Katarina AU - Lukač, Aleksandar AU - Ristanović, Aleksandar AU - Marić, Nebojša AU - Marković, Stefan AU - Šarac, Ivana AU - Ščančar, Janez PY - 2024 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1501 AB - Background : Human lung tissue, as an interface with the environment, is susceptible to various environmental pollutants, including trace metals. However, quantitative data on trace metals in human lung tissues remain poorly described. Methods: This study aimed to characterize the elemental composition of histologically healthy, unaffected parts of human lung tissues, associated with non-infective, non-infiltrative, and non-malignant diseases (n = 60) for essential (Cr, Mn, Fe, Co, Cu, Zn, and Se) and toxic trace elements (Sr, Ni, As, Cd, and Pb). Additionally, we investigated the influence of personal factors (sex, age, and smoking habits) on the examined trace element profiles, as well as between the trace elements correlations in the healthy human lungs. Results : Among the analyzed trace elements, Fe was the most prevalent, while As was the least prevalent in healthy lung tissues. Stratifying by age revealed significantly higher Cr and Co (less Sr, Ni, and Pb) and lower Se levels in older individuals (above 65 years) compared to their younger counterparts. Sex-based differences were also notable, with Cu and Co 1.2- and 2.3-fold higher levels in females than in males. Exploring the impact of smoking habits revealed a striking 10-fold increase in Cd levels in the lung tissues of smokers compared to non-smokers. Correlation analyses showed significant positive associations between concentrations of certain toxic and essential trace elements in healthy lung tissues. Conclusions: This study could contribute to the establishment of baseline intervals for essential and toxic trace elements, valuable for toxicological and clinical assessment, in healthy, unaffected human lungs, and indicates the influence of sex, age, and smoking. However, further larger-scale studies are needed to make more stable conclusions. PB - Elsevier T2 - Journal of Trace Elements in Medicine and Biology T1 - Quantitative profiling and baseline intervals of trace elements in healthy lung tissues SP - 127440 VL - 84 DO - 10.1016/j.jtemb.2024.127440 ER -
@article{ author = "Stojsavljević, Aleksandar and Marković, Katarina and Lukač, Aleksandar and Ristanović, Aleksandar and Marić, Nebojša and Marković, Stefan and Šarac, Ivana and Ščančar, Janez", year = "2024", abstract = "Background : Human lung tissue, as an interface with the environment, is susceptible to various environmental pollutants, including trace metals. However, quantitative data on trace metals in human lung tissues remain poorly described. Methods: This study aimed to characterize the elemental composition of histologically healthy, unaffected parts of human lung tissues, associated with non-infective, non-infiltrative, and non-malignant diseases (n = 60) for essential (Cr, Mn, Fe, Co, Cu, Zn, and Se) and toxic trace elements (Sr, Ni, As, Cd, and Pb). Additionally, we investigated the influence of personal factors (sex, age, and smoking habits) on the examined trace element profiles, as well as between the trace elements correlations in the healthy human lungs. Results : Among the analyzed trace elements, Fe was the most prevalent, while As was the least prevalent in healthy lung tissues. Stratifying by age revealed significantly higher Cr and Co (less Sr, Ni, and Pb) and lower Se levels in older individuals (above 65 years) compared to their younger counterparts. Sex-based differences were also notable, with Cu and Co 1.2- and 2.3-fold higher levels in females than in males. Exploring the impact of smoking habits revealed a striking 10-fold increase in Cd levels in the lung tissues of smokers compared to non-smokers. Correlation analyses showed significant positive associations between concentrations of certain toxic and essential trace elements in healthy lung tissues. Conclusions: This study could contribute to the establishment of baseline intervals for essential and toxic trace elements, valuable for toxicological and clinical assessment, in healthy, unaffected human lungs, and indicates the influence of sex, age, and smoking. However, further larger-scale studies are needed to make more stable conclusions.", publisher = "Elsevier", journal = "Journal of Trace Elements in Medicine and Biology", title = "Quantitative profiling and baseline intervals of trace elements in healthy lung tissues", pages = "127440", volume = "84", doi = "10.1016/j.jtemb.2024.127440" }
Stojsavljević, A., Marković, K., Lukač, A., Ristanović, A., Marić, N., Marković, S., Šarac, I.,& Ščančar, J.. (2024). Quantitative profiling and baseline intervals of trace elements in healthy lung tissues. in Journal of Trace Elements in Medicine and Biology Elsevier., 84, 127440. https://doi.org/10.1016/j.jtemb.2024.127440
Stojsavljević A, Marković K, Lukač A, Ristanović A, Marić N, Marković S, Šarac I, Ščančar J. Quantitative profiling and baseline intervals of trace elements in healthy lung tissues. in Journal of Trace Elements in Medicine and Biology. 2024;84:127440. doi:10.1016/j.jtemb.2024.127440 .
Stojsavljević, Aleksandar, Marković, Katarina, Lukač, Aleksandar, Ristanović, Aleksandar, Marić, Nebojša, Marković, Stefan, Šarac, Ivana, Ščančar, Janez, "Quantitative profiling and baseline intervals of trace elements in healthy lung tissues" in Journal of Trace Elements in Medicine and Biology, 84 (2024):127440, https://doi.org/10.1016/j.jtemb.2024.127440 . .