Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications
Аутори
Bumbaširević, Uroš![](/themes/MirageRIMI/images/orcid.png)
Petrović, Miloš
![](/themes/MirageRIMI/images/orcid.png)
Zeković, Milica
![](/themes/MirageRIMI/images/orcid.png)
Ćorić, Vesna
![](/themes/MirageRIMI/images/orcid.png)
Milojević, Bogomir
![](/themes/MirageRIMI/images/orcid.png)
Lisičić, Nikola
Obućina, David
Vasilić, Nenad
![](/themes/MirageRIMI/images/orcid.png)
Bulat, Petar
![](/themes/MirageRIMI/images/orcid.png)
Živković, Marko
Čekerevac, Milica
Bojanić, Nebojša
![](/themes/MirageRIMI/images/orcid.png)
Janičić, Aleksandar
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. The study involved 280 consecutive patients who underwent radical orchiectomy between 2018 and 2023. Multifocality was defined as a distinct tumor focus characterized by a group of malignant cells > 1 mm, clearly differentiated from the primary tumor mass. Uni- and multivariate logistic regression analyses were employed to investigate the association between multifocality and histopathological parameters along with potential risk factors for clinical stages II + III. Multifocality was identified in 44 (15.7%) patients. Significantly smaller primary tumors were observed in subjects with multifocality (20.0 mm vs. 30.0 mm, p = 0.0001), while those exhibiting monofocality presented a markedly elevated rate of tumors exceeding 4 cm (40.3% vs. 18.2%, p = 0....005). Furthermore, multifocality was associated with a significantly higher rate of primary tumors < 2 cm (52.3% vs. 29.2%, p = 0.003). Univariate logistic regression analysis revealed a substantial decrease in the likelihood of multifocality occurrence in seminoma patients with tumors > 4 cm (OR = 0.38, p = 0.017). Meanwhile, in multivariate logistic regression, multifocality did not emerge as a significant risk factor for clinical stages II + III in either seminoma (p = 0.381) or non-seminoma (p = 0.672) cases. Our study suggests that multifocality holds no substantial prognostic relevance for clinically advanced disease in testicular cancer patients. The findings indicate that multifocality is associated with smaller primary tumors, particularly those measuring less than 2 cm.
Кључне речи:
testicular cancer / testicular GCT / multifocality / prognostic factorsИзвор:
Life, 2024, 14, 2, 257-Издавач:
- Basel : Multidisciplinary Digital Publishing Institute (MDPI)
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200110 (Универзитет у Београду, Медицински факултет) (RS-MESTD-inst-2020-200110)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Bumbaširević, Uroš AU - Petrović, Miloš AU - Zeković, Milica AU - Ćorić, Vesna AU - Milojević, Bogomir AU - Lisičić, Nikola AU - Obućina, David AU - Vasilić, Nenad AU - Bulat, Petar AU - Živković, Marko AU - Čekerevac, Milica AU - Bojanić, Nebojša AU - Janičić, Aleksandar PY - 2024 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1491 AB - There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. The study involved 280 consecutive patients who underwent radical orchiectomy between 2018 and 2023. Multifocality was defined as a distinct tumor focus characterized by a group of malignant cells > 1 mm, clearly differentiated from the primary tumor mass. Uni- and multivariate logistic regression analyses were employed to investigate the association between multifocality and histopathological parameters along with potential risk factors for clinical stages II + III. Multifocality was identified in 44 (15.7%) patients. Significantly smaller primary tumors were observed in subjects with multifocality (20.0 mm vs. 30.0 mm, p = 0.0001), while those exhibiting monofocality presented a markedly elevated rate of tumors exceeding 4 cm (40.3% vs. 18.2%, p = 0.005). Furthermore, multifocality was associated with a significantly higher rate of primary tumors < 2 cm (52.3% vs. 29.2%, p = 0.003). Univariate logistic regression analysis revealed a substantial decrease in the likelihood of multifocality occurrence in seminoma patients with tumors > 4 cm (OR = 0.38, p = 0.017). Meanwhile, in multivariate logistic regression, multifocality did not emerge as a significant risk factor for clinical stages II + III in either seminoma (p = 0.381) or non-seminoma (p = 0.672) cases. Our study suggests that multifocality holds no substantial prognostic relevance for clinically advanced disease in testicular cancer patients. The findings indicate that multifocality is associated with smaller primary tumors, particularly those measuring less than 2 cm. PB - Basel : Multidisciplinary Digital Publishing Institute (MDPI) T2 - Life T2 - Life T1 - Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications IS - 2 SP - 257 VL - 14 DO - 10.3390/life14020257 ER -
@article{ author = "Bumbaširević, Uroš and Petrović, Miloš and Zeković, Milica and Ćorić, Vesna and Milojević, Bogomir and Lisičić, Nikola and Obućina, David and Vasilić, Nenad and Bulat, Petar and Živković, Marko and Čekerevac, Milica and Bojanić, Nebojša and Janičić, Aleksandar", year = "2024", abstract = "There are limited data regarding the significance of multifocality in testicular cancer patients. This study evaluated the relationship between multifocality and clinicopathological features determined at the time of radical orchiectomy. The study involved 280 consecutive patients who underwent radical orchiectomy between 2018 and 2023. Multifocality was defined as a distinct tumor focus characterized by a group of malignant cells > 1 mm, clearly differentiated from the primary tumor mass. Uni- and multivariate logistic regression analyses were employed to investigate the association between multifocality and histopathological parameters along with potential risk factors for clinical stages II + III. Multifocality was identified in 44 (15.7%) patients. Significantly smaller primary tumors were observed in subjects with multifocality (20.0 mm vs. 30.0 mm, p = 0.0001), while those exhibiting monofocality presented a markedly elevated rate of tumors exceeding 4 cm (40.3% vs. 18.2%, p = 0.005). Furthermore, multifocality was associated with a significantly higher rate of primary tumors < 2 cm (52.3% vs. 29.2%, p = 0.003). Univariate logistic regression analysis revealed a substantial decrease in the likelihood of multifocality occurrence in seminoma patients with tumors > 4 cm (OR = 0.38, p = 0.017). Meanwhile, in multivariate logistic regression, multifocality did not emerge as a significant risk factor for clinical stages II + III in either seminoma (p = 0.381) or non-seminoma (p = 0.672) cases. Our study suggests that multifocality holds no substantial prognostic relevance for clinically advanced disease in testicular cancer patients. The findings indicate that multifocality is associated with smaller primary tumors, particularly those measuring less than 2 cm.", publisher = "Basel : Multidisciplinary Digital Publishing Institute (MDPI)", journal = "Life, Life", title = "Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications", number = "2", pages = "257", volume = "14", doi = "10.3390/life14020257" }
Bumbaširević, U., Petrović, M., Zeković, M., Ćorić, V., Milojević, B., Lisičić, N., Obućina, D., Vasilić, N., Bulat, P., Živković, M., Čekerevac, M., Bojanić, N.,& Janičić, A.. (2024). Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications. in Life Basel : Multidisciplinary Digital Publishing Institute (MDPI)., 14(2), 257. https://doi.org/10.3390/life14020257
Bumbaširević U, Petrović M, Zeković M, Ćorić V, Milojević B, Lisičić N, Obućina D, Vasilić N, Bulat P, Živković M, Čekerevac M, Bojanić N, Janičić A. Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications. in Life. 2024;14(2):257. doi:10.3390/life14020257 .
Bumbaširević, Uroš, Petrović, Miloš, Zeković, Milica, Ćorić, Vesna, Milojević, Bogomir, Lisičić, Nikola, Obućina, David, Vasilić, Nenad, Bulat, Petar, Živković, Marko, Čekerevac, Milica, Bojanić, Nebojša, Janičić, Aleksandar, "Multifocality in Testicular Cancer: Clinicopathological Correlations and Prognostic Implications" in Life, 14, no. 2 (2024):257, https://doi.org/10.3390/life14020257 . .