Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?
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2024
Authors
Ilich, Jasminka Z.Pokimica, Biljana
Ristić-Medić, Danijela
Petrović, Snježana
Arsić, Aleksandra
Vasiljević, Nađa
Vučić, Vesna
Kelly, Owen J.
Article (Published version)
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The objectives were to examine if there is a causal relationship between osteosarcopenic adiposity (OSA) syndrome (coexistence of osteopenia/osteoporosis, sarcopenia, and excess adiposity) and cardiometabolic disorders or if these disorders initiate the development of OSA and its worsening. The search was conducted in PubMed, Scopus, and Web of Science to include articles up to the end of 2023. Of n=539 articles retrieved, n=15 met the eligibility criteria. Only studies conducted in adults and with all three body composition compartments (bone, muscle/lean, adipose) measured were considered. The results revealed that several cardiometabolic disorders, namely, hypertension, dyslipidemia (elevated total and LDL-cholesterol, lower HDL-cholesterol), insulin resistance, hyperglycemia, lower serum vitamin D, and some inflammatory markers were accompanied by OSA. In most cases, the OSA phenotype was associated with worse outcomes than cases with healthy or less impaired body composition. Our ...initial questions about the reciprocal cause-and-effect relationships could be surmised with more certainty for the OSA and some cardiovascular risks (hypertension, dyslipidemia) and some metabolic abnormalities (several inflammatory markers). The results of this review underscore the importance of body composition in health and from a clinical perspective, all three body composition compartments should be measured by standardized technologies using regulated diagnostic criteria to identify OSA. Randomized trials and prospective studies in diverse groups of older and younger individuals are necessary to determine if the relationships between OSA and clinical endpoints are causal and reversible through intervention and to uncover the mechanisms.
Keywords:
Osteosarcopenic adiposity/obesity Cardiometabolic disorders / Cardiometabolic disorders / Cardiovascular disease / Cardiovascular risk factors / Metabolic abnormalitiesSource:
Ageing Research Reviews, 2024, 98, 102326-Publisher:
- Elsevier
Funding / projects:
- Fulbright Scholar Award Project at the University of Belgrade, Serbia: PS00338126, U.S. Department of State Bureau of Education and Cultural Affairs, 2022–2023.
- Ministry of Science, Technological Development and Innovation of the Republic of Serbia, institutional funding - 200015 (University of Belgrade, Institute for Medical Research) (RS-MESTD-inst-2020-200015)
DOI: 10.1016/j.arr.2024.102326
ISSN: 1568-1637
PubMed: 38734146
Scopus: 2-s2.0-85192968189
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Institut za medicinska istraživanjaTY - JOUR AU - Ilich, Jasminka Z. AU - Pokimica, Biljana AU - Ristić-Medić, Danijela AU - Petrović, Snježana AU - Arsić, Aleksandra AU - Vasiljević, Nađa AU - Vučić, Vesna AU - Kelly, Owen J. PY - 2024 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1489 AB - The objectives were to examine if there is a causal relationship between osteosarcopenic adiposity (OSA) syndrome (coexistence of osteopenia/osteoporosis, sarcopenia, and excess adiposity) and cardiometabolic disorders or if these disorders initiate the development of OSA and its worsening. The search was conducted in PubMed, Scopus, and Web of Science to include articles up to the end of 2023. Of n=539 articles retrieved, n=15 met the eligibility criteria. Only studies conducted in adults and with all three body composition compartments (bone, muscle/lean, adipose) measured were considered. The results revealed that several cardiometabolic disorders, namely, hypertension, dyslipidemia (elevated total and LDL-cholesterol, lower HDL-cholesterol), insulin resistance, hyperglycemia, lower serum vitamin D, and some inflammatory markers were accompanied by OSA. In most cases, the OSA phenotype was associated with worse outcomes than cases with healthy or less impaired body composition. Our initial questions about the reciprocal cause-and-effect relationships could be surmised with more certainty for the OSA and some cardiovascular risks (hypertension, dyslipidemia) and some metabolic abnormalities (several inflammatory markers). The results of this review underscore the importance of body composition in health and from a clinical perspective, all three body composition compartments should be measured by standardized technologies using regulated diagnostic criteria to identify OSA. Randomized trials and prospective studies in diverse groups of older and younger individuals are necessary to determine if the relationships between OSA and clinical endpoints are causal and reversible through intervention and to uncover the mechanisms. PB - Elsevier T2 - Ageing Research Reviews T2 - Ageing Research ReviewsAgeing Research Reviews T1 - Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect? SP - 102326 VL - 98 DO - 10.1016/j.arr.2024.102326 ER -
@article{ author = "Ilich, Jasminka Z. and Pokimica, Biljana and Ristić-Medić, Danijela and Petrović, Snježana and Arsić, Aleksandra and Vasiljević, Nađa and Vučić, Vesna and Kelly, Owen J.", year = "2024", abstract = "The objectives were to examine if there is a causal relationship between osteosarcopenic adiposity (OSA) syndrome (coexistence of osteopenia/osteoporosis, sarcopenia, and excess adiposity) and cardiometabolic disorders or if these disorders initiate the development of OSA and its worsening. The search was conducted in PubMed, Scopus, and Web of Science to include articles up to the end of 2023. Of n=539 articles retrieved, n=15 met the eligibility criteria. Only studies conducted in adults and with all three body composition compartments (bone, muscle/lean, adipose) measured were considered. The results revealed that several cardiometabolic disorders, namely, hypertension, dyslipidemia (elevated total and LDL-cholesterol, lower HDL-cholesterol), insulin resistance, hyperglycemia, lower serum vitamin D, and some inflammatory markers were accompanied by OSA. In most cases, the OSA phenotype was associated with worse outcomes than cases with healthy or less impaired body composition. Our initial questions about the reciprocal cause-and-effect relationships could be surmised with more certainty for the OSA and some cardiovascular risks (hypertension, dyslipidemia) and some metabolic abnormalities (several inflammatory markers). The results of this review underscore the importance of body composition in health and from a clinical perspective, all three body composition compartments should be measured by standardized technologies using regulated diagnostic criteria to identify OSA. Randomized trials and prospective studies in diverse groups of older and younger individuals are necessary to determine if the relationships between OSA and clinical endpoints are causal and reversible through intervention and to uncover the mechanisms.", publisher = "Elsevier", journal = "Ageing Research Reviews, Ageing Research ReviewsAgeing Research Reviews", title = "Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?", pages = "102326", volume = "98", doi = "10.1016/j.arr.2024.102326" }
Ilich, J. Z., Pokimica, B., Ristić-Medić, D., Petrović, S., Arsić, A., Vasiljević, N., Vučić, V.,& Kelly, O. J.. (2024). Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?. in Ageing Research Reviews Elsevier., 98, 102326. https://doi.org/10.1016/j.arr.2024.102326
Ilich JZ, Pokimica B, Ristić-Medić D, Petrović S, Arsić A, Vasiljević N, Vučić V, Kelly OJ. Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?. in Ageing Research Reviews. 2024;98:102326. doi:10.1016/j.arr.2024.102326 .
Ilich, Jasminka Z., Pokimica, Biljana, Ristić-Medić, Danijela, Petrović, Snježana, Arsić, Aleksandra, Vasiljević, Nađa, Vučić, Vesna, Kelly, Owen J., "Osteosarcopenic adiposity (OSA) phenotype and its connection with cardiometabolic disorders: Is there a cause-and-effect?" in Ageing Research Reviews, 98 (2024):102326, https://doi.org/10.1016/j.arr.2024.102326 . .