Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients
2006
Authors
Ristić, VanjaTepšić, Vesna
Ristić-Medić, Danijela
Perunicić, Gordana
Rasić, Zorica R.
Poštić, Marija M.
Arsić, Aleksandra
Blazencic-Mladenović, Vera
Ristić, Gordana
Article (Published version)
Metadata
Show full item recordAbstract
Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid content and fatty acid composition in 37 patients with chronic renal failure on hemodialysis (HD). The results were compared with the characteristics of healthy subjects. Briefly, plasma triglyceride (p lt 0.001), total cholesterol (p lt 0.05), and total phospholipids (p lt 0.01) levels were significantly higher and HDL-cholesterol level significantly lower (p lt 0.01) in HD patients. Plasma phosphatidylcholine and phosphatidylethanolamine concentration were significantly higher (p lt 0.001) in HD patients. The plasma phospholipid fatty acids composition indicated significantly (p lt 0.01) higher level of oleic (18:1 n-9) and low...er levels of eicopentaenoic (20:5 n-3 EPA) and docosahexaenoic (22:6 n-3 DHA) acids (p lt 0.05). However, in HD patients, the relative concentration of plasma phospholipid n-6 polyunsaturated fatty acid (PUFA) was significantly lower (p lt 0.05). The fatty acid composition of erythrocyte phospholipid in HD patients was modified with EPA and DHA levels significantly lowered (p lt 0.05). Our results demonstrate an abnormal phospholipid metabolism and deficiency of n-3 PUFA in plasma and erythrocyte phospholipids in hemodialyzed patients.
Keywords:
lipids / phospholipids / fatty acids / plasma / erythrocyte / hemodialysisSource:
Renal Failure, 2006, 28, 3, 211-216Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Razvoj novih terapijskih postupaka u prevenciji i lečenju bolesti jetre: Uloga i mehanizam delovanja polinezasićenih masnih kiselina (RS-MESTD-MPN2006-2010-145071)
DOI: 10.1080/08860220600574897
ISSN: 0886-022X
PubMed: 16703792
WoS: 000237455400002
Scopus: 2-s2.0-33745714385
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Ristić, Vanja AU - Tepšić, Vesna AU - Ristić-Medić, Danijela AU - Perunicić, Gordana AU - Rasić, Zorica R. AU - Poštić, Marija M. AU - Arsić, Aleksandra AU - Blazencic-Mladenović, Vera AU - Ristić, Gordana PY - 2006 UR - http://rimi.imi.bg.ac.rs/handle/123456789/145 AB - Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid content and fatty acid composition in 37 patients with chronic renal failure on hemodialysis (HD). The results were compared with the characteristics of healthy subjects. Briefly, plasma triglyceride (p lt 0.001), total cholesterol (p lt 0.05), and total phospholipids (p lt 0.01) levels were significantly higher and HDL-cholesterol level significantly lower (p lt 0.01) in HD patients. Plasma phosphatidylcholine and phosphatidylethanolamine concentration were significantly higher (p lt 0.001) in HD patients. The plasma phospholipid fatty acids composition indicated significantly (p lt 0.01) higher level of oleic (18:1 n-9) and lower levels of eicopentaenoic (20:5 n-3 EPA) and docosahexaenoic (22:6 n-3 DHA) acids (p lt 0.05). However, in HD patients, the relative concentration of plasma phospholipid n-6 polyunsaturated fatty acid (PUFA) was significantly lower (p lt 0.05). The fatty acid composition of erythrocyte phospholipid in HD patients was modified with EPA and DHA levels significantly lowered (p lt 0.05). Our results demonstrate an abnormal phospholipid metabolism and deficiency of n-3 PUFA in plasma and erythrocyte phospholipids in hemodialyzed patients. PB - Taylor & Francis Ltd, Abingdon T2 - Renal Failure T1 - Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients EP - 216 IS - 3 SP - 211 VL - 28 DO - 10.1080/08860220600574897 ER -
@article{ author = "Ristić, Vanja and Tepšić, Vesna and Ristić-Medić, Danijela and Perunicić, Gordana and Rasić, Zorica R. and Poštić, Marija M. and Arsić, Aleksandra and Blazencic-Mladenović, Vera and Ristić, Gordana", year = "2006", abstract = "Dyslipidemia is one of the possible risk factors for advanced atherosclerosis in patients with chronic renal failure. Abnormal phospholipid metabolism may play an important role in the progression of atherosclerosis in patients with renal failure. The aim of this study was to determine specific characteristics of plasma and erythrocyte phospholipid content and fatty acid composition in 37 patients with chronic renal failure on hemodialysis (HD). The results were compared with the characteristics of healthy subjects. Briefly, plasma triglyceride (p lt 0.001), total cholesterol (p lt 0.05), and total phospholipids (p lt 0.01) levels were significantly higher and HDL-cholesterol level significantly lower (p lt 0.01) in HD patients. Plasma phosphatidylcholine and phosphatidylethanolamine concentration were significantly higher (p lt 0.001) in HD patients. The plasma phospholipid fatty acids composition indicated significantly (p lt 0.01) higher level of oleic (18:1 n-9) and lower levels of eicopentaenoic (20:5 n-3 EPA) and docosahexaenoic (22:6 n-3 DHA) acids (p lt 0.05). However, in HD patients, the relative concentration of plasma phospholipid n-6 polyunsaturated fatty acid (PUFA) was significantly lower (p lt 0.05). The fatty acid composition of erythrocyte phospholipid in HD patients was modified with EPA and DHA levels significantly lowered (p lt 0.05). Our results demonstrate an abnormal phospholipid metabolism and deficiency of n-3 PUFA in plasma and erythrocyte phospholipids in hemodialyzed patients.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Renal Failure", title = "Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients", pages = "216-211", number = "3", volume = "28", doi = "10.1080/08860220600574897" }
Ristić, V., Tepšić, V., Ristić-Medić, D., Perunicić, G., Rasić, Z. R., Poštić, M. M., Arsić, A., Blazencic-Mladenović, V.,& Ristić, G.. (2006). Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients. in Renal Failure Taylor & Francis Ltd, Abingdon., 28(3), 211-216. https://doi.org/10.1080/08860220600574897
Ristić V, Tepšić V, Ristić-Medić D, Perunicić G, Rasić ZR, Poštić MM, Arsić A, Blazencic-Mladenović V, Ristić G. Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients. in Renal Failure. 2006;28(3):211-216. doi:10.1080/08860220600574897 .
Ristić, Vanja, Tepšić, Vesna, Ristić-Medić, Danijela, Perunicić, Gordana, Rasić, Zorica R., Poštić, Marija M., Arsić, Aleksandra, Blazencic-Mladenović, Vera, Ristić, Gordana, "Plasma and erythrocyte phospholipid fatty acids composition in serbian hemodialyzed patients" in Renal Failure, 28, no. 3 (2006):211-216, https://doi.org/10.1080/08860220600574897 . .