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Androgen Dependence in Thrombosis of Patients With COVID-19
dc.creator | Miljatović, Sanja | |
dc.creator | Dragojević, Teodora | |
dc.creator | Đikić, Dragoslava | |
dc.creator | Živković, Emilija | |
dc.creator | Stevanović, Goran | |
dc.creator | Čokić, Vladan | |
dc.date.accessioned | 2024-02-02T11:43:57Z | |
dc.date.available | 2024-02-02T11:43:57Z | |
dc.date.issued | 2022 | |
dc.identifier.isbn | 978-86-80916-01-9 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1457 | |
dc.description.abstract | Background. A vascular system inflammation is a risk of venous thromboembolism and can result in widespread microangiopathy with microvascular thrombosis. Methods. We performed laboratory clinical follow-up of patients with COVID-19 to compare gender differences. To study the sex difference in COVID-19 outcome we will measure estradiol and androgens: dihydrotestosterone (DHT) and sex hormone binding globulin (SHBP) in plasma of 63 COVID-19 patients, analyzed by ELISA. Their levels will be correlated to the adhesion molecules: soluble intercellular adhesion molecule 1 (sICAM-1), soluble vascular adhesion molecule 1 (sVCAM-1), sE-selectin, and sP-selectin as biomarkers for inflammation and thrombosis. Results. DHT was increased (1.9 fold) in male COVID-19 patients compared to healthy male volunteers. SHBP was significantly increased in COVID-19 patients compared to healthy volunteers (p<0.05) as well as female vs. male COVID-19 patients (p<0.001, 2.5 fold). sVCAM-1 and sICAM-1 were increased in female COVID-19 patients compared to male COVID-19 patients and female volunteers, respectively (p<0.05). The sP-selection was significantly (p<0.01) increased in male vs. female COVID-19 patients. SHBP was in negative correlation with sP-selectin (p<0.05). DHT was in positive correlation with sVCAM-1 (p<0.05). Ferritin had 3-fold higher levels in male than female COVID-19 patients (p<0.001). Conclusions. Upregulation of androgen hormones and thrombotic biomarkers in COVID-19 patients demonstrate sex dependence. | sr |
dc.language.iso | en | sr |
dc.publisher | Belgrade: MEDAPP Association | sr |
dc.rights | openAccess | sr |
dc.source | The First World Conference Fighting COVID-19 Pandemic - Health Challenges, 26-28 March 2022, Belgrade, Serbia -Abstract book, 2022 | sr |
dc.title | Androgen Dependence in Thrombosis of Patients With COVID-19 | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.citation.epage | 391 | |
dc.citation.spage | 391 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/3431/Androgen_Dependence_in_Thrombosis_conf_2022.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimi_1457 | |
dc.type.version | publishedVersion | sr |