Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice
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2006
Authors
Bugarski, Diana
Jovčić, Gordana
Katić-Radivojević, Sofija
Petakov, Marijana
Krstić, Aleksandra

Stojanović, Nevenka
Milenković, Pavle B.

Article (Published version)

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Pinworm parasites commonly infect laboratory mice with high prevalence even in well-managed animal colonies. Although often considered as irrelevant, these parasites if undetected may significantly interfere with the experimental settings and alter the interpretation of final results. There are a few reports documenting the effects of pinworms on research and the effects of pinworms on the host hematopoiesis have not yet been investigated. In this study we examined the changes within various hematopoietic cell lineages in the bone marrow, spleen, peripheral blood and peritoneal space during naturally acquired Syphacia obvelata infection in inbred CBA mice. The data obtained showed significant hematopoietic alterations, characterized by increased myelopoiesis and erythropoiesis in S. obvelata-infected animals. In order to additionally evaluate if this pinworm infection modifies hematopoietic cells' reactivity, we examined the effect of murine interleukin-17, T cell-derived cytokine impl...icated in the regulation of hematopoiesis and inflammation, on the growth of bone marrow progenitor cells and demonstrated that bone marrow myeloid and erythroid progenitors from S. obvelata-infected mice displayed altered sensitivity to IL-17 when compared to non-infected controls. Taken together the alterations presented pointed out that this rodent pinworm is an important environmental agent that might significantly modify the hosts' hematopoietic response, and therefore interfere with the experimental settings and alter the interpretation of the final results. However, the results obtained also contributed new data concerning the activity of IL-17 on bone marrow hematopoietic cells, supporting our previous reports that depending on physiological/pathological status of the organism IL-17 exerts differential effects on the growth of progenitor-cells.
Keywords:
hematopoiesis / IL-17 / mice / Syphacia obvelataSource:
Parasitology International, 2006, 55, 2, 91-97Publisher:
- Elsevier Ireland Ltd, Clare
DOI: 10.1016/j.parint.2005.10.005
ISSN: 1383-5769
PubMed: 16325460
WoS: 000237634100001
Scopus: 2-s2.0-33646048002
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Institut za medicinska istraživanjaTY - JOUR AU - Bugarski, Diana AU - Jovčić, Gordana AU - Katić-Radivojević, Sofija AU - Petakov, Marijana AU - Krstić, Aleksandra AU - Stojanović, Nevenka AU - Milenković, Pavle B. PY - 2006 UR - http://rimi.imi.bg.ac.rs/handle/123456789/143 AB - Pinworm parasites commonly infect laboratory mice with high prevalence even in well-managed animal colonies. Although often considered as irrelevant, these parasites if undetected may significantly interfere with the experimental settings and alter the interpretation of final results. There are a few reports documenting the effects of pinworms on research and the effects of pinworms on the host hematopoiesis have not yet been investigated. In this study we examined the changes within various hematopoietic cell lineages in the bone marrow, spleen, peripheral blood and peritoneal space during naturally acquired Syphacia obvelata infection in inbred CBA mice. The data obtained showed significant hematopoietic alterations, characterized by increased myelopoiesis and erythropoiesis in S. obvelata-infected animals. In order to additionally evaluate if this pinworm infection modifies hematopoietic cells' reactivity, we examined the effect of murine interleukin-17, T cell-derived cytokine implicated in the regulation of hematopoiesis and inflammation, on the growth of bone marrow progenitor cells and demonstrated that bone marrow myeloid and erythroid progenitors from S. obvelata-infected mice displayed altered sensitivity to IL-17 when compared to non-infected controls. Taken together the alterations presented pointed out that this rodent pinworm is an important environmental agent that might significantly modify the hosts' hematopoietic response, and therefore interfere with the experimental settings and alter the interpretation of the final results. However, the results obtained also contributed new data concerning the activity of IL-17 on bone marrow hematopoietic cells, supporting our previous reports that depending on physiological/pathological status of the organism IL-17 exerts differential effects on the growth of progenitor-cells. PB - Elsevier Ireland Ltd, Clare T2 - Parasitology International T1 - Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice EP - 97 IS - 2 SP - 91 VL - 55 DO - 10.1016/j.parint.2005.10.005 UR - conv_1733 ER -
@article{ author = "Bugarski, Diana and Jovčić, Gordana and Katić-Radivojević, Sofija and Petakov, Marijana and Krstić, Aleksandra and Stojanović, Nevenka and Milenković, Pavle B.", year = "2006", abstract = "Pinworm parasites commonly infect laboratory mice with high prevalence even in well-managed animal colonies. Although often considered as irrelevant, these parasites if undetected may significantly interfere with the experimental settings and alter the interpretation of final results. There are a few reports documenting the effects of pinworms on research and the effects of pinworms on the host hematopoiesis have not yet been investigated. In this study we examined the changes within various hematopoietic cell lineages in the bone marrow, spleen, peripheral blood and peritoneal space during naturally acquired Syphacia obvelata infection in inbred CBA mice. The data obtained showed significant hematopoietic alterations, characterized by increased myelopoiesis and erythropoiesis in S. obvelata-infected animals. In order to additionally evaluate if this pinworm infection modifies hematopoietic cells' reactivity, we examined the effect of murine interleukin-17, T cell-derived cytokine implicated in the regulation of hematopoiesis and inflammation, on the growth of bone marrow progenitor cells and demonstrated that bone marrow myeloid and erythroid progenitors from S. obvelata-infected mice displayed altered sensitivity to IL-17 when compared to non-infected controls. Taken together the alterations presented pointed out that this rodent pinworm is an important environmental agent that might significantly modify the hosts' hematopoietic response, and therefore interfere with the experimental settings and alter the interpretation of the final results. However, the results obtained also contributed new data concerning the activity of IL-17 on bone marrow hematopoietic cells, supporting our previous reports that depending on physiological/pathological status of the organism IL-17 exerts differential effects on the growth of progenitor-cells.", publisher = "Elsevier Ireland Ltd, Clare", journal = "Parasitology International", title = "Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice", pages = "97-91", number = "2", volume = "55", doi = "10.1016/j.parint.2005.10.005", url = "conv_1733" }
Bugarski, D., Jovčić, G., Katić-Radivojević, S., Petakov, M., Krstić, A., Stojanović, N.,& Milenković, P. B.. (2006). Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice. in Parasitology International Elsevier Ireland Ltd, Clare., 55(2), 91-97. https://doi.org/10.1016/j.parint.2005.10.005 conv_1733
Bugarski D, Jovčić G, Katić-Radivojević S, Petakov M, Krstić A, Stojanović N, Milenković PB. Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice. in Parasitology International. 2006;55(2):91-97. doi:10.1016/j.parint.2005.10.005 conv_1733 .
Bugarski, Diana, Jovčić, Gordana, Katić-Radivojević, Sofija, Petakov, Marijana, Krstić, Aleksandra, Stojanović, Nevenka, Milenković, Pavle B., "Hematopoietic changes and altered reactivity to IL-17 in Syphacia obvelata-infected mice" in Parasitology International, 55, no. 2 (2006):91-97, https://doi.org/10.1016/j.parint.2005.10.005 ., conv_1733 .