In vitro efficacy of antibiotics against different Borrelia isolates
Само за регистроване кориснике
2021
Аутори
Veinović, GoranaĆakić, Sanja
Mihaljica, Darko
Sukara, Ratko
Ružić-Sabljić, Eva
Tomanović, Snežana
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In the present study, the effectiveness of six antimicrobial agents have been tested against 24 borrelia strains isolated from Ixodes ricinus ticks (11 Borrelia lusitaniae, eight Borrelia afzelii, three Borrelia garinii and two Borrelia valaisiana) and one B. lusitaniae strain isolated from human skin. The minimum inhibitory concentration range of antimicrobial agents was as follows: amoxicillin, 0.125–2 mg/L; doxycycline, 0.125–1 mg/L, ceftriaxone, 0.016–0.063 mg/L; cefuroxime, 0.063–1 mg/L; azithromycin, 0.0017–0.11 mg/L; amikacin 32–512 mg/L. Potentially pathogenic B. lusitaniae and B. valaisiana species were more susceptible to amoxicillin and azithromycin than pathogenic B. afzelii and B. garinii (P < 0.05); B. garinii, B. lusitaniae and B. valaisiana were more susceptible to doxycycline than B. afzelii (P < 0.05) while all species showed same susceptibility to ceftriaxone and cefuroxime (P > 0.05). This study is the first report on in vitro susceptibility of isolates from Serbia ...to antimicrobial agents and the first report on susceptibility of larger number of isolates of potentially pathogenic species B. lusitaniae. We showed that antimicrobial agents in vitro inhibit growth of borrelia strains very effectively, indicating the potential of their equally beneficial use in the treatment of Lyme borreliosis.
Кључне речи:
Borrelia / antimicrobial agents / in vitro susceptibility / treatment / Lyme borreliosisИзвор:
Acta Microbiologica Et Immunologica Hungarica, 2021, 68, 3, 195-202Издавач:
- Akademiai Kiado
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Veinović, Gorana AU - Ćakić, Sanja AU - Mihaljica, Darko AU - Sukara, Ratko AU - Ružić-Sabljić, Eva AU - Tomanović, Snežana PY - 2021 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1415 AB - In the present study, the effectiveness of six antimicrobial agents have been tested against 24 borrelia strains isolated from Ixodes ricinus ticks (11 Borrelia lusitaniae, eight Borrelia afzelii, three Borrelia garinii and two Borrelia valaisiana) and one B. lusitaniae strain isolated from human skin. The minimum inhibitory concentration range of antimicrobial agents was as follows: amoxicillin, 0.125–2 mg/L; doxycycline, 0.125–1 mg/L, ceftriaxone, 0.016–0.063 mg/L; cefuroxime, 0.063–1 mg/L; azithromycin, 0.0017–0.11 mg/L; amikacin 32–512 mg/L. Potentially pathogenic B. lusitaniae and B. valaisiana species were more susceptible to amoxicillin and azithromycin than pathogenic B. afzelii and B. garinii (P < 0.05); B. garinii, B. lusitaniae and B. valaisiana were more susceptible to doxycycline than B. afzelii (P < 0.05) while all species showed same susceptibility to ceftriaxone and cefuroxime (P > 0.05). This study is the first report on in vitro susceptibility of isolates from Serbia to antimicrobial agents and the first report on susceptibility of larger number of isolates of potentially pathogenic species B. lusitaniae. We showed that antimicrobial agents in vitro inhibit growth of borrelia strains very effectively, indicating the potential of their equally beneficial use in the treatment of Lyme borreliosis. PB - Akademiai Kiado T2 - Acta Microbiologica Et Immunologica Hungarica T1 - In vitro efficacy of antibiotics against different Borrelia isolates EP - 202 IS - 3 SP - 195 VL - 68 DO - 10.1556/030.2021.01441 ER -
@article{ author = "Veinović, Gorana and Ćakić, Sanja and Mihaljica, Darko and Sukara, Ratko and Ružić-Sabljić, Eva and Tomanović, Snežana", year = "2021", abstract = "In the present study, the effectiveness of six antimicrobial agents have been tested against 24 borrelia strains isolated from Ixodes ricinus ticks (11 Borrelia lusitaniae, eight Borrelia afzelii, three Borrelia garinii and two Borrelia valaisiana) and one B. lusitaniae strain isolated from human skin. The minimum inhibitory concentration range of antimicrobial agents was as follows: amoxicillin, 0.125–2 mg/L; doxycycline, 0.125–1 mg/L, ceftriaxone, 0.016–0.063 mg/L; cefuroxime, 0.063–1 mg/L; azithromycin, 0.0017–0.11 mg/L; amikacin 32–512 mg/L. Potentially pathogenic B. lusitaniae and B. valaisiana species were more susceptible to amoxicillin and azithromycin than pathogenic B. afzelii and B. garinii (P < 0.05); B. garinii, B. lusitaniae and B. valaisiana were more susceptible to doxycycline than B. afzelii (P < 0.05) while all species showed same susceptibility to ceftriaxone and cefuroxime (P > 0.05). This study is the first report on in vitro susceptibility of isolates from Serbia to antimicrobial agents and the first report on susceptibility of larger number of isolates of potentially pathogenic species B. lusitaniae. We showed that antimicrobial agents in vitro inhibit growth of borrelia strains very effectively, indicating the potential of their equally beneficial use in the treatment of Lyme borreliosis.", publisher = "Akademiai Kiado", journal = "Acta Microbiologica Et Immunologica Hungarica", title = "In vitro efficacy of antibiotics against different Borrelia isolates", pages = "202-195", number = "3", volume = "68", doi = "10.1556/030.2021.01441" }
Veinović, G., Ćakić, S., Mihaljica, D., Sukara, R., Ružić-Sabljić, E.,& Tomanović, S.. (2021). In vitro efficacy of antibiotics against different Borrelia isolates. in Acta Microbiologica Et Immunologica Hungarica Akademiai Kiado., 68(3), 195-202. https://doi.org/10.1556/030.2021.01441
Veinović G, Ćakić S, Mihaljica D, Sukara R, Ružić-Sabljić E, Tomanović S. In vitro efficacy of antibiotics against different Borrelia isolates. in Acta Microbiologica Et Immunologica Hungarica. 2021;68(3):195-202. doi:10.1556/030.2021.01441 .
Veinović, Gorana, Ćakić, Sanja, Mihaljica, Darko, Sukara, Ratko, Ružić-Sabljić, Eva, Tomanović, Snežana, "In vitro efficacy of antibiotics against different Borrelia isolates" in Acta Microbiologica Et Immunologica Hungarica, 68, no. 3 (2021):195-202, https://doi.org/10.1556/030.2021.01441 . .