Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis
Само за регистроване кориснике
2023
Аутори
Gatica, SebastianAravena, Cristobal
Prado, Yolanda
Aravena, Diego
Echeverría, Cesar
Santibanez, Juan F.
Riedel, Claudia A.
Stehberg, Jimmy
Simon, Felipe
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Dexmedetomidine is an adrenergic receptor agonist that has been regarded as neuroprotective in several studies without an objective measure to it. Thus, the aim of this meta-analysis was to analyze and quantify the current evidence for the neuroprotective effects of dexmedetomidine in animals. The search was performed by querying the National Library of Medicine. Studies were included based on their language, significancy of their results, and complete availability of data on animal characteristics and interventions. Risk of bias was assessed using SYRCLE’s risk of bias tool and certainty was assessed using the ARRIVE Guidelines 2.0. Synthesis was performed by calculating pooled standardized mean difference and presented in forest plots and tables. The number of eligible records included per outcome is the following: 22 for IL-1β, 13 for IL-6, 19 for apoptosis, 7 for oxidative stress, 7 for Escape Latency, and 4 for Platform Crossings. At the cellular level, dexmedetomidine was found p...rotective against production of IL-1β (standardized mean difference (SMD) = − 4.3 [− 4.8; − 3.7]) and IL-6 (SMD = − 5.6 [− 6.7; − 4.6]), apoptosis (measured through TUNEL, SMD = − 6.0 [− 6.8; − 4.6]), and oxidative stress (measured as MDA production, SMD = − 2.0 [− 2.4; − 1.4]) exclusively in the central nervous system. At the organism level, dexmedetomidine improved behavioral outcomes measuring escape latency (SMD = − 2.4 [− 3.3; − 1.6]) and number of platform crossings (SMD = 9.1 [− 6.8; − 11.5]). No eligible study had high risk of bias and certainty was satisfactory for reproducibility in all cases. This meta-analysis highlights the complexity of adrenergic stimulation and sheds light into the mechanisms potentiated by dexmedetomidine, which could be exploited for improving current neuroprotective formulations.
Кључне речи:
Adrenergic / Dexmedetomidine / Nervous system / Neuroprotection / Inflammation / Oxidative stressИзвор:
Advances in Molecular Pathology, 2023, 163-181Издавач:
- Springer Nature
Финансирање / пројекти:
- Fondo Nacionalde Desarrollo Científico y Tecnológico FONDECYT [Grant numbers 3220565 (SG), 1201039 (FS), 11170840(CE), 1191300 (CR)]
- Millennium Science Initiative Program—ICN09_016/ICN 2021_045: Millennium Institute on Immunology and Immunotherapy (ICN09_016/ICN 2021_045; former P09/016-F) (FS, CR)
- The Millennium Nucleus of Ion Channel-Associated Diseases (MiNICAD) is supported by the Iniciativa Científica Milenio ANID, Chile (FS)
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200015 (Универзитет у Београду, Институт за медицинска истраживања) (RS-MESTD-inst-2020-200015)
Институција/група
Institut za medicinska istraživanjaTY - CHAP AU - Gatica, Sebastian AU - Aravena, Cristobal AU - Prado, Yolanda AU - Aravena, Diego AU - Echeverría, Cesar AU - Santibanez, Juan F. AU - Riedel, Claudia A. AU - Stehberg, Jimmy AU - Simon, Felipe PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1380 AB - Dexmedetomidine is an adrenergic receptor agonist that has been regarded as neuroprotective in several studies without an objective measure to it. Thus, the aim of this meta-analysis was to analyze and quantify the current evidence for the neuroprotective effects of dexmedetomidine in animals. The search was performed by querying the National Library of Medicine. Studies were included based on their language, significancy of their results, and complete availability of data on animal characteristics and interventions. Risk of bias was assessed using SYRCLE’s risk of bias tool and certainty was assessed using the ARRIVE Guidelines 2.0. Synthesis was performed by calculating pooled standardized mean difference and presented in forest plots and tables. The number of eligible records included per outcome is the following: 22 for IL-1β, 13 for IL-6, 19 for apoptosis, 7 for oxidative stress, 7 for Escape Latency, and 4 for Platform Crossings. At the cellular level, dexmedetomidine was found protective against production of IL-1β (standardized mean difference (SMD) = − 4.3 [− 4.8; − 3.7]) and IL-6 (SMD = − 5.6 [− 6.7; − 4.6]), apoptosis (measured through TUNEL, SMD = − 6.0 [− 6.8; − 4.6]), and oxidative stress (measured as MDA production, SMD = − 2.0 [− 2.4; − 1.4]) exclusively in the central nervous system. At the organism level, dexmedetomidine improved behavioral outcomes measuring escape latency (SMD = − 2.4 [− 3.3; − 1.6]) and number of platform crossings (SMD = 9.1 [− 6.8; − 11.5]). No eligible study had high risk of bias and certainty was satisfactory for reproducibility in all cases. This meta-analysis highlights the complexity of adrenergic stimulation and sheds light into the mechanisms potentiated by dexmedetomidine, which could be exploited for improving current neuroprotective formulations. PB - Springer Nature T2 - Advances in Molecular Pathology T1 - Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis EP - 181 SP - 163 DO - 10.1007/978-3-031-26163-3_9 UR - https://hdl.handle.net/21.15107/rcub_rimi_1380 ER -
@inbook{ author = "Gatica, Sebastian and Aravena, Cristobal and Prado, Yolanda and Aravena, Diego and Echeverría, Cesar and Santibanez, Juan F. and Riedel, Claudia A. and Stehberg, Jimmy and Simon, Felipe", year = "2023", abstract = "Dexmedetomidine is an adrenergic receptor agonist that has been regarded as neuroprotective in several studies without an objective measure to it. Thus, the aim of this meta-analysis was to analyze and quantify the current evidence for the neuroprotective effects of dexmedetomidine in animals. The search was performed by querying the National Library of Medicine. Studies were included based on their language, significancy of their results, and complete availability of data on animal characteristics and interventions. Risk of bias was assessed using SYRCLE’s risk of bias tool and certainty was assessed using the ARRIVE Guidelines 2.0. Synthesis was performed by calculating pooled standardized mean difference and presented in forest plots and tables. The number of eligible records included per outcome is the following: 22 for IL-1β, 13 for IL-6, 19 for apoptosis, 7 for oxidative stress, 7 for Escape Latency, and 4 for Platform Crossings. At the cellular level, dexmedetomidine was found protective against production of IL-1β (standardized mean difference (SMD) = − 4.3 [− 4.8; − 3.7]) and IL-6 (SMD = − 5.6 [− 6.7; − 4.6]), apoptosis (measured through TUNEL, SMD = − 6.0 [− 6.8; − 4.6]), and oxidative stress (measured as MDA production, SMD = − 2.0 [− 2.4; − 1.4]) exclusively in the central nervous system. At the organism level, dexmedetomidine improved behavioral outcomes measuring escape latency (SMD = − 2.4 [− 3.3; − 1.6]) and number of platform crossings (SMD = 9.1 [− 6.8; − 11.5]). No eligible study had high risk of bias and certainty was satisfactory for reproducibility in all cases. This meta-analysis highlights the complexity of adrenergic stimulation and sheds light into the mechanisms potentiated by dexmedetomidine, which could be exploited for improving current neuroprotective formulations.", publisher = "Springer Nature", journal = "Advances in Molecular Pathology", booktitle = "Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis", pages = "181-163", doi = "10.1007/978-3-031-26163-3_9", url = "https://hdl.handle.net/21.15107/rcub_rimi_1380" }
Gatica, S., Aravena, C., Prado, Y., Aravena, D., Echeverría, C., Santibanez, J. F., Riedel, C. A., Stehberg, J.,& Simon, F.. (2023). Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis. in Advances in Molecular Pathology Springer Nature., 163-181. https://doi.org/10.1007/978-3-031-26163-3_9 https://hdl.handle.net/21.15107/rcub_rimi_1380
Gatica S, Aravena C, Prado Y, Aravena D, Echeverría C, Santibanez JF, Riedel CA, Stehberg J, Simon F. Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis. in Advances in Molecular Pathology. 2023;:163-181. doi:10.1007/978-3-031-26163-3_9 https://hdl.handle.net/21.15107/rcub_rimi_1380 .
Gatica, Sebastian, Aravena, Cristobal, Prado, Yolanda, Aravena, Diego, Echeverría, Cesar, Santibanez, Juan F., Riedel, Claudia A., Stehberg, Jimmy, Simon, Felipe, "Appraisal of the Neuroprotective Effect of Dexmedetomidine: A Meta-Analysis" in Advances in Molecular Pathology (2023):163-181, https://doi.org/10.1007/978-3-031-26163-3_9 ., https://hdl.handle.net/21.15107/rcub_rimi_1380 .