Spectral analysis of thioacetamide-induced electroencephalographic changes in rats
Само за регистроване кориснике
2013
Аутори
Mladenovic, DušanHrnčić, Dragan
Rašić-Marković, Aleksandra
Puškaš, Nela
Petrović, Snježana
Stanojlović, Olivera
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT ...0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.
Кључне речи:
Thioacetamide / hepatic encephalopathy / EEG / spectral analysis / ratsИзвор:
Human and Experimental Toxicology, 2013, 32, 1, 90-100Финансирање / пројекти:
- Развој анималних модела епилепсије и тестирање конвулзивних и антиконвулзивних супстанци (RS-MESTD-Basic Research (BR or ON)-175032)
DOI: 10.1177/0960327112456312
ISSN: 0960-3271
PubMed: 23111881
WoS: 000312692600010
Scopus: 2-s2.0-84871595687
Институција/група
Institut za medicinska istraživanjaTY - JOUR AU - Mladenovic, Dušan AU - Hrnčić, Dragan AU - Rašić-Marković, Aleksandra AU - Puškaš, Nela AU - Petrović, Snježana AU - Stanojlović, Olivera PY - 2013 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1375 AB - Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans. T2 - Human and Experimental Toxicology T1 - Spectral analysis of thioacetamide-induced electroencephalographic changes in rats EP - 100 IS - 1 SP - 90 VL - 32 DO - 10.1177/0960327112456312 ER -
@article{ author = "Mladenovic, Dušan and Hrnčić, Dragan and Rašić-Marković, Aleksandra and Puškaš, Nela and Petrović, Snježana and Stanojlović, Olivera", year = "2013", abstract = "Thioacetamide (TAA) is widely used as a model of hepatic encephalopathy (HE). The aim of our study was to investigate the effects of TAA on electroencephalographic (EEG) changes in rats and to compare them with human HE. Male Wistar rats were divided into groups: (1) saline-treated group and (2) TAA-treated groups: TAA(300) (300 mg/kg), TAA(600) (600 mg/kg), and TAA(900) (900 mg/kg). Daily dose of TAA (300 mg/kg) was administered intraperitoneally once (TAA(300)), twice (TAA(600)), or thrice (TAA(900)) in subsequent days. EEG changes were recorded about 24 h after the last dose of TAA. Absolute and relative power density in alpha bands were significantly higher in TAA(300) versus control group. In TAA(300), absolute beta power density was higher and relative beta power density was lower versus control group. Absolute alpha, theta, delta, and relative theta power were significantly lower, while relative power in delta band was significantly higher in TAA(900) versus control group (p LT 0.01). In conclusion, decrease in EEG voltage with an increase in delta relative power, which correspond to the EEG manifestations of severe HE in humans, was observed in TAA(900) group. Electrical activity in TAA(300) group correlates with mild HE in humans.", journal = "Human and Experimental Toxicology", title = "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats", pages = "100-90", number = "1", volume = "32", doi = "10.1177/0960327112456312" }
Mladenovic, D., Hrnčić, D., Rašić-Marković, A., Puškaš, N., Petrović, S.,& Stanojlović, O.. (2013). Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology, 32(1), 90-100. https://doi.org/10.1177/0960327112456312
Mladenovic D, Hrnčić D, Rašić-Marković A, Puškaš N, Petrović S, Stanojlović O. Spectral analysis of thioacetamide-induced electroencephalographic changes in rats. in Human and Experimental Toxicology. 2013;32(1):90-100. doi:10.1177/0960327112456312 .
Mladenovic, Dušan, Hrnčić, Dragan, Rašić-Marković, Aleksandra, Puškaš, Nela, Petrović, Snježana, Stanojlović, Olivera, "Spectral analysis of thioacetamide-induced electroencephalographic changes in rats" in Human and Experimental Toxicology, 32, no. 1 (2013):90-100, https://doi.org/10.1177/0960327112456312 . .