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Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia
dc.creator | Leković, Danijela | |
dc.creator | Bogdanović, Andrija | |
dc.creator | Sobas, Marta | |
dc.creator | Arsenović, Isidora | |
dc.creator | Smiljanić, Mihailo | |
dc.creator | Ivanović, Jelena | |
dc.creator | Bodrožić, Jelena | |
dc.creator | Čokić, Vladan | |
dc.creator | Milić, Nataša | |
dc.date.accessioned | 2023-09-18T09:01:37Z | |
dc.date.available | 2023-09-18T09:01:37Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2072-6694 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1344 | |
dc.description.abstract | Essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (prePMF) initially have a similar phenotypic presentation with thrombocytosis. The aim of our study was to determine significant clinical-laboratory parameters at presentation to differentiate prePMF from ET as well as to develop and validate a predictive diagnostic prePMF model. This retrospective study included 464 patients divided into ET (289 pts) and prePMF (175 pts) groups. The model was built using data from a development cohort (229 pts; 143 ET, 86 prePMF), which was then tested in an internal validation cohort (235 pts; 146 ET, 89 prePMF). The most important prePMF predictors in the multivariate logistic model were age ≥ 60 years (RR = 2.2), splenomegaly (RR = 13.2), and increased lactat-dehidrogenase (RR = 2.8). Risk scores were assigned according to derived relative risk (RR) for age ≥ 60 years (1 point), splenomegaly (2 points), and increased lactat-dehidrogenase (1 point). Positive predictive value (PPV) for pre-PMF diagnosis with a score of ≥points was 69.8%, while for a score of ≥3 it was 88.2%. Diagnostic performance had similar values in the validation cohort. In MPN patients with thrombocytosis at presentation, the application of the new model enables differentiation of pre-PMF from ET, which is clinically relevant considering that these diseases have different prognoses and treatments. | |
dc.language | en | |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Cancers | |
dc.source | Cancers | |
dc.subject | prefibrotic primary myelofibrosis (pre-PMF) | |
dc.subject | essential thrombocythemia (ET) | |
dc.subject | differentialdiagnosis | |
dc.subject | predictive model | |
dc.title | Easily Applicable Predictive Score for Differential Diagnosis of Prefibrotic Primary Myelofibrosis from Essential Thrombocythemia | |
dc.type | article | en |
dc.rights.license | BY | |
dc.citation.issue | 16 | |
dc.citation.spage | 4180 | |
dc.citation.volume | 15 | |
dc.identifier.doi | 10.3390/cancers15164180 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/3086/Easily_Applicable_Predictive_Score_for_Differential_pub_2023.pdf | |
dc.type.version | publishedVersion |