Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects
Authors
Ristić-Medić, Danijela
Petrović, Snježana

Takić, Marija

Vučić, Vesna

Arsić, Aleksandra

Rađen, Slavica
Glibetić, Marija

Article (Published version)
Metadata
Show full item recordAbstract
Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid
(FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate
the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in
erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean
age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed
lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6%
and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids,
i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid
(DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid-
lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/
HDL and triacyl...glycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively
correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total
serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with
homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased
serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower
risk of cardiovascular disease in subjects with moderate hyperlipidemia.
Keywords:
Fatty acid ratio / Hyperlipidemia / Lipid-lowering diet / Omega 3-index / TG/HDLSource:
Acta clinica Croatica, 2022, 61, 2, 220-226Publisher:
- Klinicka bolnica Sestre Milosrdnice
Funding / projects:
Collections
Institution/Community
Institut za medicinska istraživanjaTY - JOUR AU - Ristić-Medić, Danijela AU - Petrović, Snježana AU - Takić, Marija AU - Vučić, Vesna AU - Arsić, Aleksandra AU - Rađen, Slavica AU - Glibetić, Marija PY - 2022 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1338 AB - Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid (FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6% and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids, i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid (DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid- lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/ HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower risk of cardiovascular disease in subjects with moderate hyperlipidemia. PB - Klinicka bolnica Sestre Milosrdnice T2 - Acta clinica Croatica T1 - Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects EP - 226 IS - 2 SP - 220 VL - 61 DO - 10.20471/acc.2022.61.02.08 ER -
@article{ author = "Ristić-Medić, Danijela and Petrović, Snježana and Takić, Marija and Vučić, Vesna and Arsić, Aleksandra and Rađen, Slavica and Glibetić, Marija", year = "2022", abstract = "Polyunsaturated fatty acid (PUFA) dietary intake, status and serum key fatty acid (FA) ratios may aid in cardiovascular disease-related risk assessment. The aim of this study was to investigate the effects of lipid-lowering diet on key FA ratios in serum phospholipids and omega-3 index in erythrocyte phospholipids in moderately hyperlipidemic subjects. The study included 41 subjects, mean age 56±6 years. Nutritional habits were evaluated by food frequency questionnaire. Participants followed lipid lowering diet for 12 weeks. Energy intake of omega-6 and omega-3 FA was changed from 7.6% and 0.6% to 5.7% and 1.2%, respectively. Marked decrease in four FA ratios in serum phospholipids, i.e., omega-6/omega-3, arachidonic acid (AA)/eicosapentaenoic acid (EPA), AA/docosahexaenoic acid (DHA), AA/(EPA+DHA) and omega-3 index (EPA+DHA) was found in study subjects after lipid- lowering diet. Total cholesterol/high-density lipoprotein (HDL), low-density lipoprotein (LDL)/ HDL and triacylglycerol/HDL-cholesterol ratios positively correlated with all FA ratios, and negatively correlated with total omega-3 levels in serum phospholipids and omega-3 index in erythrocytes. Total serum omega-3 levels showed strongest association with lipoprotein ratios and positive correlation with homeostatic model assessment (HOMA) index. In conclusion, lipid-lowering diet resulted in decreased serum key FA ratios, increased omega-3 levels, and improved insulin sensitivity that may lead to a lower risk of cardiovascular disease in subjects with moderate hyperlipidemia.", publisher = "Klinicka bolnica Sestre Milosrdnice", journal = "Acta clinica Croatica", title = "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects", pages = "226-220", number = "2", volume = "61", doi = "10.20471/acc.2022.61.02.08" }
Ristić-Medić, D., Petrović, S., Takić, M., Vučić, V., Arsić, A., Rađen, S.,& Glibetić, M.. (2022). Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica Klinicka bolnica Sestre Milosrdnice., 61(2), 220-226. https://doi.org/10.20471/acc.2022.61.02.08
Ristić-Medić D, Petrović S, Takić M, Vučić V, Arsić A, Rađen S, Glibetić M. Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects. in Acta clinica Croatica. 2022;61(2):220-226. doi:10.20471/acc.2022.61.02.08 .
Ristić-Medić, Danijela, Petrović, Snježana, Takić, Marija, Vučić, Vesna, Arsić, Aleksandra, Rađen, Slavica, Glibetić, Marija, "Efficacy of a Lipid-Lowering Diet on Key Fatty Acid Ratios and Omega-3 Index in Hyperlipidemic Subjects" in Acta clinica Croatica, 61, no. 2 (2022):220-226, https://doi.org/10.20471/acc.2022.61.02.08 . .