Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project
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2023
Authors
Casulli, Adriano
Abela-Ridder, Bernadette
Petrone, Daniele
Fabiani, Massimo

Bobić, Branko

Carmena, David

Šoba, Barbara
Zerem, Enver

Gargaté, Maria João
Kuzmanovska, Gordana
Calomfirescu, Cristian
Rainova, Iskra
Sotiraki, Smaragda

Lungu, Vera
Dezsényi, Balázs
Herrador, Zaida

Karamon, Jacek

Maksimov, Pavlo
Oksanen, Antti
Millon, Laurence
Sviben, Mario
Shkjezi, Renata
Gjoni, Valbona
Akshija, Ilir

Saarma, Urmas
Torgerson, Paul R.

Šnábel, Viliam

Antolová, Daniela

Muhović, Damir

Besim, Hasan
Chereau, Fanny
Belhassen García, Moncef
Chappuis, François

Gloor, Severin
Stoeckle, Marcel
Müllhaupt, Beat
Manno, Valerio

Santoro, Azzurra

Santolamazza, Federica

Article (Published version)

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The neglected zoonosis cystic echinococcosis affects mainly pastoral and rural communities in both low-income and upper-middle-income countries. In Europe, it should be regarded as an orphan and rare disease. Although human cystic echinococcosis is a notifiable parasitic infectious disease in most European countries, in practice it is largely under-reported by national health systems. To fill this gap, we extracted data on the number, incidence, and trend of human cases in Europe through a systematic review approach, using both the scientific and grey literature and accounting for the period of publication from 1997 to 2021. The highest number of possible human cases at the national level was calculated from various data sources to generate a descriptive model of human cystic echinococcosis in Europe. We identified 64 745 human cystic echinococcosis cases from 40 European countries. The mean annual incidence from 1997 to 2020 throughout Europe was 0·64 cases per 100 000 people and in E...U member states was 0·50 cases per 100 000 people. Based on incidence rates and trends detected in this study, the current epicentre of cystic echinococcosis in Europe is in the southeastern European countries, whereas historical endemic European Mediterranean countries have recorded a decrease in the number of cases over the time.
Source:
The Lancet Infectious Diseases, 2023, 23, 3, e95-e107Publisher:
- Elsevier
Funding / projects:
- MEmE project from the EU’s Horizon 2020 Research and Innovation programme under grant agreement number 773830: One Health European Joint Programme
- Research funding (grant PRG1209) from the Estonian Ministry of Education and Research
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Institut za medicinska istraživanjaTY - JOUR AU - Casulli, Adriano AU - Abela-Ridder, Bernadette AU - Petrone, Daniele AU - Fabiani, Massimo AU - Bobić, Branko AU - Carmena, David AU - Šoba, Barbara AU - Zerem, Enver AU - Gargaté, Maria João AU - Kuzmanovska, Gordana AU - Calomfirescu, Cristian AU - Rainova, Iskra AU - Sotiraki, Smaragda AU - Lungu, Vera AU - Dezsényi, Balázs AU - Herrador, Zaida AU - Karamon, Jacek AU - Maksimov, Pavlo AU - Oksanen, Antti AU - Millon, Laurence AU - Sviben, Mario AU - Shkjezi, Renata AU - Gjoni, Valbona AU - Akshija, Ilir AU - Saarma, Urmas AU - Torgerson, Paul R. AU - Šnábel, Viliam AU - Antolová, Daniela AU - Muhović, Damir AU - Besim, Hasan AU - Chereau, Fanny AU - Belhassen García, Moncef AU - Chappuis, François AU - Gloor, Severin AU - Stoeckle, Marcel AU - Müllhaupt, Beat AU - Manno, Valerio AU - Santoro, Azzurra AU - Santolamazza, Federica PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1323 AB - The neglected zoonosis cystic echinococcosis affects mainly pastoral and rural communities in both low-income and upper-middle-income countries. In Europe, it should be regarded as an orphan and rare disease. Although human cystic echinococcosis is a notifiable parasitic infectious disease in most European countries, in practice it is largely under-reported by national health systems. To fill this gap, we extracted data on the number, incidence, and trend of human cases in Europe through a systematic review approach, using both the scientific and grey literature and accounting for the period of publication from 1997 to 2021. The highest number of possible human cases at the national level was calculated from various data sources to generate a descriptive model of human cystic echinococcosis in Europe. We identified 64 745 human cystic echinococcosis cases from 40 European countries. The mean annual incidence from 1997 to 2020 throughout Europe was 0·64 cases per 100 000 people and in EU member states was 0·50 cases per 100 000 people. Based on incidence rates and trends detected in this study, the current epicentre of cystic echinococcosis in Europe is in the southeastern European countries, whereas historical endemic European Mediterranean countries have recorded a decrease in the number of cases over the time. PB - Elsevier T2 - The Lancet Infectious Diseases T1 - Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project EP - e107 IS - 3 SP - e95 VL - 23 DO - 10.1016/S1473-3099(22)00638-7 ER -
@article{ author = "Casulli, Adriano and Abela-Ridder, Bernadette and Petrone, Daniele and Fabiani, Massimo and Bobić, Branko and Carmena, David and Šoba, Barbara and Zerem, Enver and Gargaté, Maria João and Kuzmanovska, Gordana and Calomfirescu, Cristian and Rainova, Iskra and Sotiraki, Smaragda and Lungu, Vera and Dezsényi, Balázs and Herrador, Zaida and Karamon, Jacek and Maksimov, Pavlo and Oksanen, Antti and Millon, Laurence and Sviben, Mario and Shkjezi, Renata and Gjoni, Valbona and Akshija, Ilir and Saarma, Urmas and Torgerson, Paul R. and Šnábel, Viliam and Antolová, Daniela and Muhović, Damir and Besim, Hasan and Chereau, Fanny and Belhassen García, Moncef and Chappuis, François and Gloor, Severin and Stoeckle, Marcel and Müllhaupt, Beat and Manno, Valerio and Santoro, Azzurra and Santolamazza, Federica", year = "2023", abstract = "The neglected zoonosis cystic echinococcosis affects mainly pastoral and rural communities in both low-income and upper-middle-income countries. In Europe, it should be regarded as an orphan and rare disease. Although human cystic echinococcosis is a notifiable parasitic infectious disease in most European countries, in practice it is largely under-reported by national health systems. To fill this gap, we extracted data on the number, incidence, and trend of human cases in Europe through a systematic review approach, using both the scientific and grey literature and accounting for the period of publication from 1997 to 2021. The highest number of possible human cases at the national level was calculated from various data sources to generate a descriptive model of human cystic echinococcosis in Europe. We identified 64 745 human cystic echinococcosis cases from 40 European countries. The mean annual incidence from 1997 to 2020 throughout Europe was 0·64 cases per 100 000 people and in EU member states was 0·50 cases per 100 000 people. Based on incidence rates and trends detected in this study, the current epicentre of cystic echinococcosis in Europe is in the southeastern European countries, whereas historical endemic European Mediterranean countries have recorded a decrease in the number of cases over the time.", publisher = "Elsevier", journal = "The Lancet Infectious Diseases", title = "Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project", pages = "e107-e95", number = "3", volume = "23", doi = "10.1016/S1473-3099(22)00638-7" }
Casulli, A., Abela-Ridder, B., Petrone, D., Fabiani, M., Bobić, B., Carmena, D., Šoba, B., Zerem, E., Gargaté, M. J., Kuzmanovska, G., Calomfirescu, C., Rainova, I., Sotiraki, S., Lungu, V., Dezsényi, B., Herrador, Z., Karamon, J., Maksimov, P., Oksanen, A., Millon, L., Sviben, M., Shkjezi, R., Gjoni, V., Akshija, I., Saarma, U., Torgerson, P. R., Šnábel, V., Antolová, D., Muhović, D., Besim, H., Chereau, F., Belhassen García, M., Chappuis, F., Gloor, S., Stoeckle, M., Müllhaupt, B., Manno, V., Santoro, A.,& Santolamazza, F.. (2023). Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project. in The Lancet Infectious Diseases Elsevier., 23(3), e95-e107. https://doi.org/10.1016/S1473-3099(22)00638-7
Casulli A, Abela-Ridder B, Petrone D, Fabiani M, Bobić B, Carmena D, Šoba B, Zerem E, Gargaté MJ, Kuzmanovska G, Calomfirescu C, Rainova I, Sotiraki S, Lungu V, Dezsényi B, Herrador Z, Karamon J, Maksimov P, Oksanen A, Millon L, Sviben M, Shkjezi R, Gjoni V, Akshija I, Saarma U, Torgerson PR, Šnábel V, Antolová D, Muhović D, Besim H, Chereau F, Belhassen García M, Chappuis F, Gloor S, Stoeckle M, Müllhaupt B, Manno V, Santoro A, Santolamazza F. Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project. in The Lancet Infectious Diseases. 2023;23(3):e95-e107. doi:10.1016/S1473-3099(22)00638-7 .
Casulli, Adriano, Abela-Ridder, Bernadette, Petrone, Daniele, Fabiani, Massimo, Bobić, Branko, Carmena, David, Šoba, Barbara, Zerem, Enver, Gargaté, Maria João, Kuzmanovska, Gordana, Calomfirescu, Cristian, Rainova, Iskra, Sotiraki, Smaragda, Lungu, Vera, Dezsényi, Balázs, Herrador, Zaida, Karamon, Jacek, Maksimov, Pavlo, Oksanen, Antti, Millon, Laurence, Sviben, Mario, Shkjezi, Renata, Gjoni, Valbona, Akshija, Ilir, Saarma, Urmas, Torgerson, Paul R., Šnábel, Viliam, Antolová, Daniela, Muhović, Damir, Besim, Hasan, Chereau, Fanny, Belhassen García, Moncef, Chappuis, François, Gloor, Severin, Stoeckle, Marcel, Müllhaupt, Beat, Manno, Valerio, Santoro, Azzurra, Santolamazza, Federica, "Unveiling the incidences and trends of the neglected zoonosis cystic echinococcosis in Europe: a systematic review from the MEmE project" in The Lancet Infectious Diseases, 23, no. 3 (2023):e95-e107, https://doi.org/10.1016/S1473-3099(22)00638-7 . .