Transforming growth factor beta 1 (TGF-β1) in COVID-19 patients: relation to platelets and association with the disease outcome
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2023
Authors
Živančević-Simonović, Snežana
Minić, Rajna

Ćupurdija, Vojislav
Stanojević-Pirković, Marijana

Milošević-Đorđević, Olivera

Jakovljević, Vladimir
Mihaljević, Olgica
Article (Published version)

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Transforming growth factor beta (TGF-β) is a ubiquitously distributed cytokine known to contribute to the pathogenesis of numerous pathological processes. The aim of this study was to measure serum concentrations of TGF-β1 in severely ill COVID-19 patients and to analyze its relationship with selected hematological and biochemical parameters and with the disease outcome. The study population included 53 COVID-19 patients with severe clinical expression of the disease and 15 control subjects. TGF-β1 was determined in serum samples and supernatants from PHA-stimulated whole blood cultures using ELISA assay. Biochemical and hematological parameters were analyzed using standard accepted methods. Our results showed that serum levels of TGF-β1 in COVID-19 patients and controls correlate with the platelet counts. Also, positive correlations of TGF-β1 with white blood cell and lymphocyte counts, platelet-to-lymphocyte (PLR) ratio, and fibrinogen level were shown, while negative correlations of... this cytokine with platelet distribution width (PDW), D-dimer and activated partial thromboplastin time (a-PTT) values in COVID-19 patients were observed. The lower serum values of TGF-β1 were associated with the unfavorable outcome of COVID-19. In conclusion, TGF-β1 levels were strongly associated with platelet counts and unfavorable disease outcome of severely ill COVID-19 patients.
Keywords:
COVID-19 / Transforming growth factor beta / COVID-19 / Pneumonia / Platelets / Disease outcomeSource:
Molecular and Cellular Biochemistry, 2023Publisher:
- Springer Nature
Funding / projects:
- Preclinical investigation of bioactive substances (RS-41010)
- Faculty of Medical Sciences, University of Kragujevac (Grant No. JP 08/17)
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Institut za medicinska istraživanjaTY - JOUR AU - Živančević-Simonović, Snežana AU - Minić, Rajna AU - Ćupurdija, Vojislav AU - Stanojević-Pirković, Marijana AU - Milošević-Đorđević, Olivera AU - Jakovljević, Vladimir AU - Mihaljević, Olgica PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1321 AB - Transforming growth factor beta (TGF-β) is a ubiquitously distributed cytokine known to contribute to the pathogenesis of numerous pathological processes. The aim of this study was to measure serum concentrations of TGF-β1 in severely ill COVID-19 patients and to analyze its relationship with selected hematological and biochemical parameters and with the disease outcome. The study population included 53 COVID-19 patients with severe clinical expression of the disease and 15 control subjects. TGF-β1 was determined in serum samples and supernatants from PHA-stimulated whole blood cultures using ELISA assay. Biochemical and hematological parameters were analyzed using standard accepted methods. Our results showed that serum levels of TGF-β1 in COVID-19 patients and controls correlate with the platelet counts. Also, positive correlations of TGF-β1 with white blood cell and lymphocyte counts, platelet-to-lymphocyte (PLR) ratio, and fibrinogen level were shown, while negative correlations of this cytokine with platelet distribution width (PDW), D-dimer and activated partial thromboplastin time (a-PTT) values in COVID-19 patients were observed. The lower serum values of TGF-β1 were associated with the unfavorable outcome of COVID-19. In conclusion, TGF-β1 levels were strongly associated with platelet counts and unfavorable disease outcome of severely ill COVID-19 patients. PB - Springer Nature T2 - Molecular and Cellular Biochemistry T2 - Molecular and Cellular Biochemistry T1 - Transforming growth factor beta 1 (TGF-β1) in COVID-19 patients: relation to platelets and association with the disease outcome DO - 10.1007/s11010-023-04674-7 ER -
@article{ author = "Živančević-Simonović, Snežana and Minić, Rajna and Ćupurdija, Vojislav and Stanojević-Pirković, Marijana and Milošević-Đorđević, Olivera and Jakovljević, Vladimir and Mihaljević, Olgica", year = "2023", abstract = "Transforming growth factor beta (TGF-β) is a ubiquitously distributed cytokine known to contribute to the pathogenesis of numerous pathological processes. The aim of this study was to measure serum concentrations of TGF-β1 in severely ill COVID-19 patients and to analyze its relationship with selected hematological and biochemical parameters and with the disease outcome. The study population included 53 COVID-19 patients with severe clinical expression of the disease and 15 control subjects. TGF-β1 was determined in serum samples and supernatants from PHA-stimulated whole blood cultures using ELISA assay. Biochemical and hematological parameters were analyzed using standard accepted methods. Our results showed that serum levels of TGF-β1 in COVID-19 patients and controls correlate with the platelet counts. Also, positive correlations of TGF-β1 with white blood cell and lymphocyte counts, platelet-to-lymphocyte (PLR) ratio, and fibrinogen level were shown, while negative correlations of this cytokine with platelet distribution width (PDW), D-dimer and activated partial thromboplastin time (a-PTT) values in COVID-19 patients were observed. The lower serum values of TGF-β1 were associated with the unfavorable outcome of COVID-19. In conclusion, TGF-β1 levels were strongly associated with platelet counts and unfavorable disease outcome of severely ill COVID-19 patients.", publisher = "Springer Nature", journal = "Molecular and Cellular Biochemistry, Molecular and Cellular Biochemistry", title = "Transforming growth factor beta 1 (TGF-β1) in COVID-19 patients: relation to platelets and association with the disease outcome", doi = "10.1007/s11010-023-04674-7" }
Živančević-Simonović, S., Minić, R., Ćupurdija, V., Stanojević-Pirković, M., Milošević-Đorđević, O., Jakovljević, V.,& Mihaljević, O.. (2023). Transforming growth factor beta 1 (TGF-β1) in COVID-19 patients: relation to platelets and association with the disease outcome. in Molecular and Cellular Biochemistry Springer Nature.. https://doi.org/10.1007/s11010-023-04674-7
Živančević-Simonović S, Minić R, Ćupurdija V, Stanojević-Pirković M, Milošević-Đorđević O, Jakovljević V, Mihaljević O. Transforming growth factor beta 1 (TGF-β1) in COVID-19 patients: relation to platelets and association with the disease outcome. in Molecular and Cellular Biochemistry. 2023;. doi:10.1007/s11010-023-04674-7 .
Živančević-Simonović, Snežana, Minić, Rajna, Ćupurdija, Vojislav, Stanojević-Pirković, Marijana, Milošević-Đorđević, Olivera, Jakovljević, Vladimir, Mihaljević, Olgica, "Transforming growth factor beta 1 (TGF-β1) in COVID-19 patients: relation to platelets and association with the disease outcome" in Molecular and Cellular Biochemistry (2023), https://doi.org/10.1007/s11010-023-04674-7 . .