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Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic
dc.creator | Čokić, Vladan | |
dc.creator | Popovska, Zorana | |
dc.creator | Lijeskić, Olivera | |
dc.creator | Šabić, Ljiljana | |
dc.creator | Đurković-Đaković, Olgica | |
dc.date.accessioned | 2023-07-25T08:45:19Z | |
dc.date.available | 2023-07-25T08:45:19Z | |
dc.date.issued | 2023 | |
dc.identifier.issn | 2152-5250 | |
dc.identifier.uri | http://rimi.imi.bg.ac.rs/handle/123456789/1317 | |
dc.description.abstract | Older people in nursing homes (NH) have been hit particularly hard by the COVID-19 pandemic. We conducted a retrospective study of three outbreaks of COVID-19, occurring during the waves of the initial pre-Alpha, Delta and Omicron SARS-CoV-2 variants, in one NH in suburban Belgrade, Serbia. All staff and 95% residents were vaccinated in February 2021, mostly with BBIBP-CorV, and two thirds were boosted with a third dose in August 2021. COVID-19 was diagnosed by positive PCR and/or antigen test. After the first outbreak, 80 affected individuals were tested for SARS-CoV-2 specific antibodies. The first outbreak involved 64/126 (50.8%) residents and 45/64 (70.3%) staff, the second 22/75 (29.3%) residents and 3/40 (7.5%) staff, and the third involved 36/110 (32.7%) residents and 19/56 (33.9%) staff. Clinical presentation ranged from asymptomatic to severe, with severe cases referred to hospital ICUs. Deaths occurred only in residents, and the case fatality rate was 31.2%, 9.1% and 0%, respectively in outbreaks 1, 2 and 3. Specific IgG antibodies were detected in all 35 residents and 44 of the 45 staff, and higher IgG levels were detected in the residents (417.3±273.5) than in the staff (201.9±192.9, p<0.0001) despite a double difference in age (79.0±7.4 vs. 40.1±11.5 years). Outbreaks 2 and 3 involved four and 23 breakthrough infections, respectively. Older individuals mounted a good immunological response to SARS-CoV-2 infection and vaccination, which prevented significant mortality and severe morbidity in the subsequent outbreaks, despite a significant number of breakthrough infections. | |
dc.language | en | |
dc.publisher | International Society on Aging and Disease | |
dc.relation | info:eu-repo/grantAgreement/ScienceFundRS/Fond_2020_COVID19/7547934/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/inst-2020/200015/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Aging and disease | |
dc.subject | COVID-19 | |
dc.subject | SARS CoV-2 variants | |
dc.subject | nursing home | |
dc.subject | residents | |
dc.subject | staff | |
dc.subject | outcome | |
dc.subject | case fatality rate | |
dc.subject | sex-related differences | |
dc.subject | SARS-CoV-2 specific antibodies | |
dc.title | Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic | |
dc.type | article | en |
dc.rights.license | BY | |
dc.citation.epage | 111 | |
dc.citation.issue | 1 | |
dc.citation.spage | 99 | |
dc.citation.volume | 14 | |
dc.identifier.doi | 10.14336/AD.2022.0624 | |
dc.identifier.fulltext | http://rimi.imi.bg.ac.rs/bitstream/id/3007/Three_Outbreaks_of_COVID-19_in_a_Single_Nursing_Home_PUB_2023.pdf | |
dc.type.version | publishedVersion |