Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women
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2023
Authors
Bajerska, Joanna
Skoczek-Rubińska, Aleksandra
Małczak, Lidia
Vučić, Vesna

Arsić, Aleksandra

Kojadinović, Milica

Ristić-Medić, Danijela

Article (Published version)

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It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the p...ercentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.
Keywords:
Atherogenic index of plasma / Cardiovascular risk / Dietary intake / Fatty acids / Postmenopausal womenSource:
Nutrition Research, 2023, 115, 47-60Publisher:
- Elsevier
Funding / projects:
- Polish National Science Centre award (grant numbers UMO-2018/29/N/NZ9/01700)
- Polish National Agency for Academic Exchange and the Exchange Programme for Scientists as part of bilateral cooperation (grant number: PPN/BIL/2020/1/00240/U/00001)
- Ministry of Education, Science and Technological Development, Republic of Serbia, Grant no. 200015 (University of Belgrade, Institute for Medical Research) (RS-200015)
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Institut za medicinska istraživanjaTY - JOUR AU - Bajerska, Joanna AU - Skoczek-Rubińska, Aleksandra AU - Małczak, Lidia AU - Vučić, Vesna AU - Arsić, Aleksandra AU - Kojadinović, Milica AU - Ristić-Medić, Danijela PY - 2023 UR - http://rimi.imi.bg.ac.rs/handle/123456789/1310 AB - It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment. PB - Elsevier T2 - Nutrition Research T2 - Nutrition ResearchNutrition Research T1 - Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women EP - 60 SP - 47 VL - 115 DO - 10.1016/j.nutres.2023.05.008 ER -
@article{ author = "Bajerska, Joanna and Skoczek-Rubińska, Aleksandra and Małczak, Lidia and Vučić, Vesna and Arsić, Aleksandra and Kojadinović, Milica and Ristić-Medić, Danijela", year = "2023", abstract = "It is hypothesized that plasma proportion of selected fatty acids (FAs) and dietary habits are linked with the risk of cardiovascular disease (CVD) in postmenopausal women. Therefore, this study was designed to determine the association of plasma FA composition and markers of dietary habits with an atherogenic index of plasma (AIP), a predictor of CVD risk in postmenopausal women. In total, 87 postmenopausal women with an average age of 57 ± 7 years were recruited and their dietary intake, anthropometric and biochemical parameters, and FA status in total plasma lipid proportions were determined, showing that 65.5% of the participants had a high risk of CVD according to their AIP value. After adjusting for some confounders (age, body mass index, and physical activity level), the risk of CVD was only positively associated with the frequency of consumption of animal fat spreads (butter and lard) of terrestrial origin. Regarding the FA profile, CVD risk was positively associated with the percentages of vaccenic acid, dihomo-γ-linolenic acid, and monounsaturated fatty acids (MUFA; mainly n-7) in total FA, as well as the MUFA/SFA ratio in total plasma and stearoyl-CoA desaturase-16 activity (16:1/16:0 ratio). In contrast, the risk of CVD was negatively associated with percentages of α-linolenic acid, total polyunsaturated fatty acids (PUFA), and PUFA/MUFA ratio in total plasma lipid, and the estimated activity of Δ5-desaturase (20:4/20:3 n-6 ratio). These results support the current recommendations to decrease the frequency of animal fat spread intake because it is associated with a reduced CVD risk based on AIP in postmenopausal women. In accordance with these plasma percentages of ALA, vaccenic acid, dihomo-γ-linolenic acid, PUFA, PUFA/MUFA ratio, and 16:1/16:0 ratio may be important parameters in CVD risk assessment.", publisher = "Elsevier", journal = "Nutrition Research, Nutrition ResearchNutrition Research", title = "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women", pages = "60-47", volume = "115", doi = "10.1016/j.nutres.2023.05.008" }
Bajerska, J., Skoczek-Rubińska, A., Małczak, L., Vučić, V., Arsić, A., Kojadinović, M.,& Ristić-Medić, D.. (2023). Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research Elsevier., 115, 47-60. https://doi.org/10.1016/j.nutres.2023.05.008
Bajerska J, Skoczek-Rubińska A, Małczak L, Vučić V, Arsić A, Kojadinović M, Ristić-Medić D. Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women. in Nutrition Research. 2023;115:47-60. doi:10.1016/j.nutres.2023.05.008 .
Bajerska, Joanna, Skoczek-Rubińska, Aleksandra, Małczak, Lidia, Vučić, Vesna, Arsić, Aleksandra, Kojadinović, Milica, Ristić-Medić, Danijela, "Plasma fatty acid composition and some markers of dietary habits are associated with cardiovascular disease risk determined by an atherogenic plasma index in postmenopausal women" in Nutrition Research, 115 (2023):47-60, https://doi.org/10.1016/j.nutres.2023.05.008 . .